PředmětyPředměty(verze: 845)
Předmět, akademický rok 2018/2019
   Přihlásit přes CAS
Farmakologie - EA0906100
Anglický název: Pharmacology
Zajišťuje: Ústav farmakologie (14-100)
Fakulta: Lékařská fakulta v Plzni
Platnost: od 2017
Semestr: zimní
Body: 6
E-Kredity: 6
Způsob provedení zkoušky: zimní s.:
letní s.:
Rozsah, examinace: zimní s.:2/1 Z [hodiny/týden]
letní s.:2/1 Z+Zk [hodiny/týden]
Počet míst: zimní:neomezen / neomezen (neurčen)
letní:neomezen / neomezen (neurčen)
Minimální obsazenost: neomezen
Stav předmětu: vyučován
Jazyk výuky: angličtina
Způsob výuky: prezenční
Úroveň:  
Poznámka: odhlásit z termínu zkoušky při nesplněné rekvizitě
Garant: doc. RNDr. Eva Kmoníčková, CSc.
doc. MUDr. Jaroslav Koutenský, CSc.
Vyučující: MUDr. Monika Bludovská, Ph.D.
doc. RNDr. Eva Kmoníčková, CSc.
MUDr. Metoděj Kolek, Ph.D.
Kategorizace předmětu: Lékařství > Teoretické předměty
Korekvizity : EA0903003, EA0903010, EA0903015, EA0904010, EA0904011
Je korekvizitou pro: EA0907450, EA0908360, EA0908480, EA0909034, EA0907380, EA0909460, EA0208024, EA0908310, EA0908023, EA0909033
Anotace - angličtina
Poslední úprava: doc. RNDr. Eva Kmoníčková, CSc. (16.11.2017)
Pharmacology is lively scientific discipline integrating knowledge of medical education starting with anatomy, histology. To understand pharmacological principles of drug efficacy, very food knowledge of biochemistry, physiology is requested and basic knowledge of pathophysiology and pathology as well.
Having completed an undergraduate degree in Pharmacology and the ability to successively work as clinicians, undergraduate dentists receive education in prescribing drugs safely and economically and are educated in principles of drug action. Overall knowledge of general medicine pharmacology is needed to make good decision for patient in dentistry office. The main attention is focused to mechanism of action of drug, its therapeutic effect , adverse effects, also to risk of toxicity, drug-drug interactions (prescribed often by other clinician), drug-food interactions.
To understand how drug acts, the content of Pharmacology teaching is based on chapters of general pharmacology and special parts.
General pharmacology covers pharmacodynamics (i.e. general principles of drug action, chemical mediators, receptors and other drug targets, dose-response relationship) and pharmacokinetics, i.e. absorption, distribution, metabolism , elimination (ADME) of drug. Special parts of pharmacology are devoted to body systems (cardiovascular etc.), strategy of treatment of diseases and groups of drugs according their mechanism of action. Indications, adverse effects, drug-drug interactions , contraindications are discussed. Also the role of medicinal plants is included.
Outcomes and skills: After 2 semesters of Pharmacology lessons and seminars, graduates will have knowledge in pharmacotherapy related specifically to dentistry and general knowledge in pharmacotherapy from other medicinal disciplines. The graduates will be able to integrate key elements of pharmacology to make pharmacotherapy effective, safe and economic. They will be able to provide safe and legal prescription. For actual information, they know and use drug databases. They follow regulatory authorities (EMA, FDA, SÚKL). They are able to recognize and report unexpected adverse effects. They should be opened for lifelong learning. They implement new approaches in clinical practice together with personal evaluation cost/benefit of pharmacotherapeutics.

Literatura - angličtina
Poslední úprava: doc. RNDr. Eva Kmoníčková, CSc. (14.11.2017)

Compulsory: 

Dowd Frank j. et al.: PPHARMACOLOGY AND THERAPEUTICS FOR DENTISTRY, 7th Ed., Mosby, 2016

DENTAL DRUG REFERENCE (with clinical implications) 2nd Ed., F.A. Pickett, G.T. Térézhalmy (Lippincot Williams and Wilkins), Publisher: LWW, 2009

 

Recommended:

Neal M.J.: MEDICAL PHARMACOLOGY AT A GLANCE, 8th Ed., John Wiley Sons, 2016

Whalen K at al.: LIPPINCOTT ILLUSTRATED REVIEWS: PHARMACOLOGY, 6th Ed., Wolters Kluwer

Rang H. P.: RANG & DALE´s PHARMACOLOGY, 8th Ed., Elsevier health Sciences, 2016

Požadavky ke zkoušce - angličtina
Poslední úprava: Irena Zemenová (22.05.2018)

Winter Semester

Pharmacology - EA0906100

 

Credit requirements:

Attendance at seminars, oral presentation covering latest news in pharmacy and therapeutics, submission of computer simulated experiments report and passing a credit test (covering the materials from the seminars) are compulsory. There is one regular date and two resit dates for the credit test.

Credit in SIS and signed credit in Credit Book is needed.

  

Summer Semester

Pharmacology - EA0906100

 

Credit requirements:

Attendance at seminars, oral presentation covering latest news in pharmacy and therapeutics, submission of computer simulated experiments report and passing a credit test (covering the materials from the seminars) are compulsory. There is one regular date and two resit dates for the credit test.

Credit in SIS and signed credit in Credit Book is needed.

 

 

Exam requirements:

Credit in SIS and signed credit in Credit Book is needed.

 

G E N E R A L      P  H A R M A C O L O G Y

Names of drugs, Definition of drug (various meaning)

 

Drug origin

 

Pharmacokinetics, Pharmacodynamics

 

New drugs -clinical trials, Placebo, Double blind experiments

 

Pharmacokinetic parameters and processes

 

CL, Vd, KE, T1/2, AUC, Bioavailability

 

Ways of administration of drugs, Single and  repeated administration

 

Permeation of biological membranes by drugs

 

Absorption of drugs

 

Distribution and redistribution , Blood proteins and drugs, barriers

 

Ways of the excretion of drugs, Renal excretion

 

Enterohepatic circulation

 

Biotransformation of drugs, Phases, Reactions, CYP 450;

 

Induction and inhibition of enzymes, Pharmacogenetic, First pass effect

 

Effects of drugs, Specific, non specific effects, Drug target sites, Agonists and antagonists, Type of antagonism. Synergism (additive, potentiation) Dose x effect (graded-quantal)

 

Tolerance, resistence, drug dependence -characteristics

 

Adverse effects and reactions, Hypersensitivity and idiosyncrasy, Types of allergy

 

Adverse effects of drugs in mouth, Drugs and teeth

 

Drugs interaction (with drugs, food and diseases), Contraindications of drugs

 

Drugs in children, drugs in pregnancy, drugs in elderly, drugs and breast feeding

 

Compliance (Adherence) Emergency drugs in dental office

 

S P E C I A L      P  H A R M A C O L O G Y

Peripheral and central nervous system - Transmitters, Agonists and Antagonists

 

Autonomic nervous system, Parasympathetic, Sympathetic, Cholinergic transmission, Parasympatomimetics, Parasympatolytics

 

Cholinesterases, Anticholinesterases, Reactivators of cholinesterases

 

Neuromuscular blocking agents, Drugs against spasm and spasticity

 

Adrenergic transmission, Sympathomimetics, Sympatholytics

 

Analgesics, Antipyretics, NSAIDs, DMARDs, Orofacial pain, Neuropathic pain,

 

Trigeminal pain

 

Histamine, Antihistamines, Immunomodulators

 

General anaesthetics, General anaesthesia, Perioperative drugs, Local anaesthetics

 

Anxiolytics and Hypnoticis in dentistry, Antiemetics

 

Antiepileptics and Antiparkinsonics and dentistry

 

CNS stimulants, Drug dependence, Antidepressants, Antipsychotic drugs

 

Cardiovascular pharmacotherapy and dentistry

 

Vitamin K, Anticoagulants, Antiagregants

 

Fibrinolysis, Antifibrinolytics, Control of coagulation, Drugs influencing the haemopoiesis

 

Gastrointestinal tract disorders and their pharmacotherapy

 

Hormonal therapy (overview) and substitution Glucocorticosteroids, use in stomatology

 

Anticancer drugs (overview)

 

Antibiotics and Antibacterial drugs in stomatology

 

Antifungal drugs in stomatology

 

Drugs acting on oropharynx (local treatment)

 

Dry mouth treatment

 

Natural Antioxidants

 

Vitamins, Minerals relevant to stomatology (A, B, C, D, E, K and Ca, F, Se)

 

Mercury, Chronic intoxication, Antidotes

 

Drugs in emergency, recommendation for Dentistry office

 

Sylabus - angličtina
Poslední úprava: doc. RNDr. Eva Kmoníčková, CSc. (14.11.2017)

PHARMACOLOGY - 3rd year   

DENTISTRY

 SYLLABUS IN DETAILS

 G E N E R A L      P  H A R M A C O L O G Y

Names of drugs, Definition of drug (various meaning)

Drug origin

Pharmacokinetics, Pharmacodynamics

New drugs -clinical trials, Placebo, Double blind experiments

Pharmacokinetic parameters and processes

CL, Vd, KE, T1/2, AUC, Bioavailability

Ways of administration of drugs, Single and  repeated administration

Permeation of biological membranes by drugs

Absorption of drugs

Distribution and redistribution , Blood proteins and drugs, barriers

Ways of the excretion of drugs, Renal excretion

Enterohepatic circulation

Biotransformation of drugs, Phases, Reactions, CYP 450;

Induction and inhibition of enzymes, Pharmacogenetic, First pass effect

Effects of drugs, Specific, non specific effects, Drug target sites, Agonists and antagonists, Type of antagonism. Synergism (additive, potentiation) Dose x effect (graded-quantal)

Tolerance, resistence, drug dependence -characteristics

Adverse effects and reactions, Hypersensitivity and idiosyncrasy, Types of allergy

Adverse effects of drugs in mouth, Drugs and teeth

Drugs interaction (with drugs, food and diseases), Contraindications of drugs

Drugs in children, drugs in pregnancy, drugs in elderly, drugs and breast feeding

Compliance (Adherence) Emergency drugs in dental office

 

S P E C I A L      P  H A R M A C O L O G Y

Peripheral and central nervous system - Transmitters, Agonists and Antagonists

Autonomic nervous system, Parasympathetic, Sympathetic, Cholinergic transmission, Parasympatomimetics, Parasympatolytics

Cholinesterases, Anticholinesterases, Reactivators of cholinesterases

Neuromuscular blocking agents, Drugs against spasm and spasticity

Adrenergic transmission, Sympathomimetics, Sympatholytics

Analgesics, Antipyretics, NSAIDs, DMARDs, Orofacial pain, Neuropathic pain,

Trigeminal pain

Histamine, Antihistamines, Immunomodulators

General anaesthetics, General anaesthesia, Perioperative drugs, Local anaesthetics

Anxiolytics and Hypnoticis in dentistry, Antiemetics

Antiepileptics and Antiparkinsonics and dentistry

CNS stimulants, Drug dependence, Antidepressants, Antipsychotic drugs

Cardiovascular pharmacotherapy and dentistry

Vitamin K, Anticoagulants, Antiagregants

Fibrinolysis, Antifibrinolytics, Control of coagulation, Drugs influencing the haemopoiesis

Gastrointestinal tract disorders and their pharmacotherapy

Hormonal therapy (overview) and substitution Glucocorticosteroids, use in stomatology

Anticancer drugs (overview)

Antibiotics and Antibacterial drugs in stomatology

Antifungal drugs in stomatology

Drugs acting on oropharynx (local treatment)

Dry mouth treatment

Natural Antioxidants

Vitamins, Minerals relevant to stomatology (A, B, C, D, E, K and Ca, F, Se)

Mercury, Chronic intoxication, Antidotes

Drugs in emergency, recommendation for Dentistry office

 

 

 
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