Molecular Bioelectromagnetism - NBCM348

• Title: Molecular Bioelectromagnetism
• Guaranteed by: Institute of Physics of Charles University (32-FUUK)
• Faculty: Faculty of Mathematics and Physics
• Actual: from 2021
• Semester: summer
• E-Credits: 3
• Hours per week, examination: summer s.:2/0, Ex [HT]
• Capacity: unlimited
• Min. number of students: unlimited
• 4EU+: no
• Virtual mobility / capacity: no
• State of the course: taught
• Language: English
• Teaching methods: full-time
• Teaching methods: full-time
• Guarantor: prof. RNDr. Josef Štěpánek, CSc.; Ing. Michal Cifra, Ph.D.

Annotation

English

Last update: RNDr. Vladimír Kopecký, Ph.D. (23.06.2021)

This course will provide fundamentals as well as current advances in the science of interaction of electromagnetic field with biological matter, particularly focusing on radiofrequency and microwave band as well as broadband, short electric pulses. The course will also cover the current knowledge of electrodynamic activity of cells. In all areas, the focus will be on the molecular and cellular level of the underlying biophysical mechanisms with selected examples of applications in biomedicine and bionanotechnology. The course is aimed mainly on students in master and doctoral programs.

Czech

Last update: RNDr. Vladimír Kopecký, Ph.D. (23.06.2021)

Přednáška seznámí se základy stejně jako se současnými pokroky ve výzkumu interakce elektromagnetického pole s biologickou látkou, zejména se zaměří na radiofrekvenční a mikrovlnné pásmo stejně tak jako na širokopásmové krátké elektrické pulsy. Přednáška rovněž pokrývá současné znalosti elektromagnetické buněčné aktivity. Ve všech oblastech bude kladen důraz na molekulární a buněčnou úroveň základních biofyzikálních mechanismů spolu s vybranými příklady aplikací v biomedicíně a bionanotechnologii. Přednáška je především určena studentům magisterských a doktorských programů.

Aim of the course

Last update: prof. RNDr. Petr Heřman, CSc. (27.06.2019)

To acquaint students of biophysics at the doctoral and master level with the basics of bioelectromagnetism.

Course completion requirements

English

Last update: RNDr. Vladimír Kopecký, Ph.D. (23.06.2021)

Pass the oral exam.

Czech

Last update: RNDr. Vladimír Kopecký, Ph.D. (23.06.2021)

Složení ústní zkoušky.

Syllabus

Last update: prof. RNDr. Josef Štěpánek, CSc. (22.06.2021)

1. Motivation for electromagnetics & bio research; fundamentals of electromagnetic (EM) field (basic terminology and laws).

2. EM spectrum; wave-particle duality of EM field/photon; technical and natural EM sources; detectors of EM field; fundamentals of EM field interaction with the matter and biomatter.

3. Structure of biomatter from EM perspective (water, lipids, nucleic acids, proteins); molecular charge distribution, net charge, dipole.

4. Dielectric properties of biomolecules, cells and tissues in radiofrequency and microwave band: complex permittivity frequency dependence, analytical models, mixing rules,

dielectric increment, time scales of relaxation processes.

5. Measurement techniques of complex permittivity with the focus on radiofrequency and microwave band.

6. Planar and chip technology for molecular bioelectromagnetics: radiofrequency & microwave microfluidics; methods for permittivity measurement.

7. Chips for EM exposure of cells and biomolecular structures; chips combined with microscopy techniques for real-time imaging of EM field interaction with biomatter.

8. Mechanisms of the response of biomaterials to electromagnetic field: pulsed electric field bioeffects, effects on protein & cytoskeleton systems.

9. Dielectric and vibrational properties of microtubules; microtubule structure, mechanical properties, vibration modes.

10. Endogenous electrodynamic activity of cells: hypothesis of microtubule vibrations as source of microwave EM fluctuations, potential energy sources.

11. Endogenous generation of electron excited in active biomatter: mechanisms, chemiexcitation pathways, detection, spectrum imaging & applications.