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Course, academic year 2023/2024
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Structure, Dynamics and Functions of Biomembranes - NBCM014
Title: Struktura, dynamika a funkce biologických membrán
Guaranteed by: Institute of Physics of Charles University (32-FUUK)
Faculty: Faculty of Mathematics and Physics
Actual: from 2020
Semester: winter
E-Credits: 3
Hours per week, examination: winter s.:2/0, Ex [HT]
Capacity: unlimited
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
State of the course: taught
Language: Czech
Teaching methods: full-time
Teaching methods: full-time
Guarantor: RNDr. Vladimír Kopecký, Ph.D.
RNDr. Kateřina Hofbauerová, Ph.D.
RNDr. Eva Kočišová, Ph.D.
Classification: Physics > Biophysics and Chemical Physics
Annotation -
Last update: T_FUUK (18.05.2001)
Chemical composition and structure of biological membranes. Membrane lipids. Membrane proteins. Lipid-protein interactions. The interaction of small molecules with biomembranes. Electric properties of cell membranes, membrane potential. Pores, channels and transporters. Membrane fusion. Membrane spectroscopy. Biogenesis of biomembranes.
Course completion requirements -
Last update: RNDr. Kateřina Hofbauerová, Ph.D. (30.10.2019)

Oral exam.

Literature -
Last update: prof. RNDr. Marek Procházka, Ph.D. (30.04.2019)

Základy buněčné biologie - Úvod do molekulární biologie buňky, Alberts Bruce, Bray Dennis, Johnson Alexande, Lewis Julia, 2. vydání, Espero Publishing, 2005.

Biochemie, Voet Donald, Voetová Judith G., Victoria Publishing, Praha, 1994.

An Introduction to Biological Membranes, William Stillwell, 2nd Edition, Elsevier Science, 2016.

Physics of Biological Membranes, Bassereau Patricia, Sens Pierre (Eds.), Springer, 2018.

The Biophysics of Cell Membranes, Epand Richard M., Ruysschaert Jean-Marie (Eds.), Springer, 2017.

Teaching methods - Czech
Last update: RNDr. Vladimír Kopecký, Ph.D. (15.09.2021)

Přednášky budou probíhat prezenční formou. Nadále však budou k dispozici v prostředí Microsoft Teams (kód týmu: y91ww2o).

Syllabus -
Last update: RNDr. Vladimír Kopecký, Ph.D. (30.10.2019)

Fundamental concepts, chemical composition of biological membranes. Membrane lipids. Thermodynamic principles. Water structure and hydrophobic effect. Thermodynamic aspects of lipid aggregation/lipid polymorphism. Phase transitions in lipid aggregates. Model lipid membranes, planar membranes, liposomes. Membrane proteins, purification of membrane proteins, experimental methods used to study protein structure, structure of membrane proteins, the synthesis of membrane proteins and endoplasmic reticulum. Lipid-protein interactions, membrane "fluidity". The interaction of small molecules with biomembranes. Electric properties of cell membranes, membrane potential. Pores, channels and transporters. Membrane fusion. Membrane spectroscopy, fluorescence, NMR, EPR - principles, instrumentation, applications.

 
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