Subjects

Your browser does not support JavaScript, or its support is disabled. Some features may not be available.

Structure of biopolymers - MC250P10

Title:	Struktura biologických makromolekul
Guaranteed by:	Department of Biochemistry (31-250)
Faculty:	Faculty of Science
Actual:	from 2018 to 2018
Semester:	summer
E-Credits:	3
Examination process:	summer s.:
Hours per week, examination:	summer s.:2/0, Ex [HT]
Capacity:	unlimited
Min. number of students:	unlimited
4EU+:	no
Virtual mobility / capacity:	no
State of the course:	taught
Language:	English
Note:	enabled for web enrollment

Guarantor:	prof. RNDr. Jiří Hudeček, CSc.
Teacher(s):	prof. RNDr. Jiří Hudeček, CSc.

Opinion survey results Examination dates Schedule

Annotation -

Last update: prof. RNDr. Jiří Hudeček, CSc. (04.01.2010)

Principles of structure of biological macromolecules, methods of its description, comparison and prediction. Intra- and intermolecular interactions. Proteins and polypeptides, evolution, prediction, folding and stability, structural classification. Nucleic acids, nomenclature and structure, Polysacharides. Glycoproteins and proteoglycans. Lignin. Supramolecular structures, virions, prions. Supportive structures, transduction of chemical to mechanical energy.

Lectures - in Czech -

Literature -

Last update: prof. RNDr. Jiří Hudeček, CSc. (04.01.2010)

Branden C, Tooze J.: Introduction to Protein Structure, Garland, N. York 1991.

Berg JM, Tymoczko JL, Stryer L.: Biochemistry, 6th Ed., WH Freeman, N York 2007.

Requirements to the exam -

Last update: prof. RNDr. Jiří Hudeček, CSc. (04.01.2010)

Oral exam, based on the syllabus.

Syllabus -

Last update: SIMONAT (30.04.2002)

1. Peptides and globular proteins. Basic structural concepts, physico-chemical characteristics. Description of structure - internal coordinates, diedral angles, Ramachandran plot. Structural hierarchy, primary, secondary, tertiary and quarternary structure in classical sense and as defined in IUB/IUPAC recommendations. Supersecondary structure, structural motifs, domains. Structural classification. Prediction and modelling of stucture. Structural comparisons. Protein folding and dynamics, denaturation. Thermostable proteins, integral membrane proteins.

2. Nucleic acids. Basic description, internal coordinates, approximate structural description. RNA, DNA structural types. Description of double helices, base pairing. Z-DNA and triple helix.

3. Polysaccharides. Basic description. Structural types - starch, cellulose, pectin, heparin.

4. Supportive and structural elements. General principles of their structure Fibrous proteins - fibrin, collagenes, keratins, fibroins.Proteoglycans. Lignin..

5. Conversion of chemical energy to movement. Muscle proteins. Cillia and flagella.