Fungal Pathogens and Interaction with their Hosts - MB140P30E

• Title: Fungal Pathogens and Interaction with their Hosts
• Czech title: Patogenní kvasinky a houby a jejich interakce s hostitelem.
• Guaranteed by: Department of Genetics and Microbiology (31-140)
• Faculty: Faculty of Science
• Actual: from 2021
• Semester: summer
• E-Credits: 5
• Examination process: summer s.:combined
• Hours per week, examination: summer s.:2/2, C+Ex [HT]
• Extent per academic year: 1 [weeks]
• Capacity: unlimited
• Min. number of students: unlimited
• 4EU+: no
• Virtual mobility / capacity: no
• State of the course: cancelled
• Language: English
• Note: enabled for web enrollment
• Guarantor: Derek Wilkinson, Ph.D.

Annotation

English

Last update: Derek Wilkinson, Ph.D. (26.06.2021)

Major fungal pathogens including Candida and thermally dimorphic species. Topics include: innate and adaptive immunity, nutritional immunity and host cell metabolism as well as fungal virulence factors (including phenotypic switching and filamental growth), circumvention of immunity and nutritional immunity, stress responses and methods of studying transcriptomic, proteomic and metabolomic changes in pathogens and their hosts.

Czech

Last update: Derek Wilkinson, Ph.D. (26.06.2021)

Přednáška pokrývá celé spektrum strategie interakcí houbových patogenů s jejich hostitelem, přičemž jednotlivá
témata se týkají:
- hlavních patogenů představujících největší problémy zejména v medicíně, jakými jsou Candida albicans, C.
glabrata, a jiní zástupci Candida spp., Aspergillus fumigatus, A. flavus a Histoplasma capsulatum a jejich strategie
přežívání v savčím hostiteli
- imunity hostitele a jejího obelstění patogenem
- buněčné morfogeneze a jejího vlivu na virulenci a rezistenci
- buněčné stěny a povrchových proteinů hub ve spojitosti s problémy v medicíně
- využívání živin a obsazování vhodných nik při infekci
- stresové odpovědi a adaptaci patogenů a hostitele
- změnám v metabolizmu hostitele a patogenů
- metod studia využitelných ve výzkumu i v klinické praxi (transkriptomika, metabolomika, proteomika)
Praktická cvičení vhodně pokrývají témata přednášky a jsou zaměřena především na problematiku přepínání
fenotypů, dimorfizmu a filamentálního růstu patogenních houbových organizmů, tedy problematiku důležitou ve
spojitosti s medicínou a lidským zdravím.

Literature

English

Last update: Derek Wilkinson, Ph.D. (04.05.2021)

Kavanagh, Kevin. Biology and Applications. New York, USA: John Wiley and Sons Ltd, 2005.

https://onlinelibrary.wiley.com/doi/book/10.1002/0470015330

Bieganska, M. J. "Two fundamentals of mammalian defense in fungal infections: Endothermy and innate antifungal immunity." Polish journal of veterinary sciences 17.3 (2014).

https://pubmed.ncbi.nlm.nih.gov/25286672/

Van Dyke, Marley C. Caballero, Marcus M. Teixeira, and Bridget M. Barker. "Fantastic yeasts and where to find them: the hidden diversity of dimorphic fungal pathogens." Current opinion in microbiology 52 (2019): 55-63.

https://pubmed.ncbi.nlm.nih.gov/31181385/

 Abad, Ana. What makes Aspergillus fumigatus a successful pathogen? Genes and molecules involved in invasive aspergillosis. Revista iberoamericana de micologia 27.4 (2010): 155-182.

https://pubmed.ncbi.nlm.nih.gov/20974273/

Brown, Gordon D. Hidden killers: human fungal infections. Science translational medicine 4.165 (2012): 165rv13-165rv13.

https://stm.sciencemag.org/content/4/165/165rv13.short

Li, Zhongming, & Kirsten Nielsen. Morphology changes in human fungal pathogens upon interaction with the host." Journal of Fungi 3.4 (2017): 66.

https://www.mdpi.com/2309-608X/3/4/66

Sheppard DC, Filler SG. Host cell invasion by medically important fungi. Cold Spring Harbor perspectives in medicine. 2015 Jan 1;5(1):a019687.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292075/ 

Li Z, Nielsen K. Morphology changes in human fungal pathogens upon interaction with the host. Journal of Fungi. 2017 Dec 1;3(4):66.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753168/ 

Marcos CM, de Oliveira HC, de Melo WD, da Silva JD, Assato PA, Scorzoni L, Rossi SA, de Paula e Silva AC, Mendes-Giannini MJ, Fusco-Almeida AM. Anti-immune strategies of pathogenic fungi. Frontiers in cellular and infection microbiology. 2016 Nov 15;6:142.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108756/ 

Vylkova S. Environmental pH modulation by pathogenic fungi as a strategy to conquer the host. PLoS pathogens. 2017 Feb 23;13(2):e1006149.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322887/

Czech

Last update: RNDr. Irena Lichá, CSc. (22.03.2019)

Bongomin F, Gago S, Oladele R, Denning D. Global and multi-national prevalence of fungal diseases—estimate precision. Journal of Fungi. 2017;3(4):57.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753159/

 

Antachopoulos C. Invasive fungal infections in congenital immunodeficiencies. Clinical Microbiology and Infection. 2010 Sep 1;16(9):1335-42.

https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1469-0691.2010.03289.x

 

Sheppard DC, Filler SG. Host cell invasion by medically important fungi. Cold Spring Harbor perspectives in medicine. 2015 Jan 1;5(1):a019687.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292075/

 

Li Z, Nielsen K. Morphology changes in human fungal pathogens upon interaction with the host. Journal of Fungi. 2017 Dec 1;3(4):66.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753168/

 

Marcos CM, de Oliveira HC, de Melo WD, da Silva JD, Assato PA, Scorzoni L, Rossi SA, de Paula e Silva AC, Mendes-Giannini MJ, Fusco-Almeida AM. Anti-immune strategies of pathogenic fungi. Frontiers in cellular and infection microbiology. 2016 Nov 15;6:142.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5108756/

 

Vylkova S. Environmental pH modulation by pathogenic fungi as a strategy to conquer the host. PLoS pathogens. 2017 Feb 23;13(2):e1006149.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5322887/

Syllabus

Last update: Derek Wilkinson, Ph.D. (26.06.2021)

Date      Derek Wilkinson               Introduction; Aspergillosis & Penicilliosis

Date      Derek Wilkinson               Mucormycosis; Fusariosis

Date      Derek Wilkinson               Lomentosporosis & Scedosporosis; Phaeohyphomycosis

Date      Derek Wilkinson               C. albicans Candidiasis; C. glabrata Candidiasis

Date      Derek Wilkinson               Non-albicans/glabrata Candidiasis; Saccharomycosis

Date      Derek Wilkinson               Cryptococcosis

Date      Derek Wilkinson               Ajellomyces, Emergomycosis & Lobomycosis; Sporotrichosis

Date      Derek Wilkinson               Coccidioidomycosis; Paracoccidioidomycosis

Date      Derek Wilkinson               Blastomycosis; Talaromycosis

Date      Derek Wilkinson               Histoplasmosis; Pneumocystis mycosis

Date      Derek Wilkinson               Malassezia mycosis; Dermatophytosis

Date      Derek Wilkinson               Studying host pathogen interactions