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Recent achievements in genetics - MB140P19E

Title:	Recent achievements in genetics
Czech title:	Novinky v genetice
Guaranteed by:	Department of Genetics and Microbiology (31-140)
Faculty:	Faculty of Science
Actual:	from 2020
Semester:	summer
E-Credits:	1
Examination process:	summer s.:
Hours per week, examination:	summer s.:1/0, Ex [HT]
Capacity:	unlimited
Min. number of students:	3
4EU+:	no
Virtual mobility / capacity:	no
State of the course:	taught
Language:	English
Level:	specialized
Additional information:	http://dl2.cuni.cz/course/view.php?id=249
Note:	enabled for web enrollment

Guarantor:	RNDr. Michaela Schierová, Ph.D.
Teacher(s):	RNDr. Michaela Schierová, Ph.D.
Incompatibility :	MB140P19
Is incompatible with:	MB140P19

Opinion survey results Examination dates SS schedule

Annotation -

Last update: RNDr. Michaela Schierová, Ph.D. (11.02.2019)

The course consists of few independent lectures giving the students idea about the recent trends in genetics. The main subjects of the lectures are: cloning in animals , gene therapy, gene interactions of tumorsupressor gene TP53, dosage compensation of sex chromosome linked genes, regulation of X chromosome inactivation, mutagen testing in food, etc. The list of topics will be modified every year.

New topics from 2019:

Genome-Wide Association Studies for Human Complex Trait Genetics
DNA reparation, cell cycle checkpoints, cancer therapy (the function, regulation and interaction of selected genes/ proteins)
Oogenesis - recombination, aneuploidy, DNA reparation, mother age effect, embryo quality)

Literature -

Last update: RNDr. Jana Rubešová, Ph.D. (21.01.2014)

Students are provided presentations to lectures, reviews and web sites.

Requirements to the exam

Last update: RNDr. Michaela Schierová, Ph.D. (02.05.2021)

There is an oral exam. The students are given two topics. The students who presented a topic of their choice can choose one of the topic themselves. The recent requirements (2020/21) are carefully described at Moodle.

Syllabus -

Last update: RNDr. Michaela Schierová, Ph.D. (24.10.2019)

Cloning in animals: reproductive and therapeutical cloning. Different grades of pluripotency in cells. Embryonic stem cells and induced pluripotent cells. Xenotransplantations. Pluripotency, reprogramming and epigenetic changes.

The main features of gene therapy. Interesting protocols for therapy hereditary or age related diseases.

Gene interactions of tumorsupressor gene TP53 and main principles of its regulation: gene structure and mutations, protein structure and posttranslational modifications. Interacting proteins.

Sex chromosomes and gene dosage compensation. Regulation of X inactivation. X skewing and disease phenotype in heterozygous females.

Assessing of mutagenicity in food: main classes of mutagens present in food, antimutagens, different test and its application..

From 2019:

Genome-Wide Association Studies for Human Complex Trait Genetics
DNA reparation, cell cycle checkpoints, cancer therapy (the function, regulation and interaction of selected genes/ proteins)
Oogenesis - recombination, aneuploidy, DNA reparation, mother age effect, embryo quality)