Bioorganic Chemistry - GDEBCH05

• Title: Bioorganic Chemistry
• Guaranteed by: Department of Organic And Bioorganic Chemistry (16-16120)
• Faculty: Faculty of Pharmacy in Hradec Králové
• Actual: from 2020
• Semester: both
• Points: 0
• E-Credits: 0
• Hours per week, examination: 0/0, Ex [HT]
• Capacity: winter:unknown / unknown (unknown); summer:unknown / unknown (unknown)
• Min. number of students: unlimited
• 4EU+: no
• Virtual mobility / capacity: no
• State of the course: taught
• Language: English
• Teaching methods: full-time
• Teaching methods: full-time
• Note: course is intended for doctoral students only; enabled for web enrollment; you can enroll for the course in winter and in summer semester
• Guarantor: prof. PharmDr. Kateřina Vávrová, Ph.D.
• Interchangeability : GDEB05

Annotation

Last update: prof. PharmDr. Kateřina Vávrová, Ph.D. (21.09.2021)

The aim of the subject Bioorganic chemistry is to broaden the PhD students´ knowledge of drug interactions with natural compounds and possibilities to influence these interactions through chemical modifications. The subject includes two main topics: chemistry of natural compounds (proteins, saccharides, nucleic acids and lipids) and drug development and their behavior in the organism (for example, structure optimization, drug behavior in the organism, physicochemical properties of drugs and non-covalent interactions between drug and its target).

Course completion requirements

Last update: prof. PharmDr. Kateřina Vávrová, Ph.D. (21.09.2021)

Oral examination.

Literature

Last update: prof. PharmDr. Kateřina Vávrová, Ph.D. (24.10.2019)

Recommended:

• Cairns, Donald (ed.). Essentials of pharmaceutical chemistry. London: Pharmaceutical Press, 2012, s. ISBN 978-0-85369-979-8.
• Wilson, Charles Owens, Gisvold, Ole. Textbook of organic medicinal and pharmaceutical chemistry. Philadelphia: Lippincott Williams & Wilkins, 2004, s. ISBN 0-7817-3481-9.
• McMurry, John. Organic chemistry. Pacific Grove: Brooks/Cole, 1996, s. ISBN 0-534-23832-7.

Requirements to the exam

Last update: prof. PharmDr. Kateřina Vávrová, Ph.D. (21.09.2021)

Chemistry of natural compounds (classification, structures, properties, stereochemistry, reactivity)

1.      Amino acids

2.      Peptides and proteins

3.      Monosaccharides

4.      Disaccharides and polysaccharides

5.      Nucleic bases, nucleosides, nucleotides

6.      Nucleic acids

7.      Lipids (incl. fatty acids, fats, oils, waxes, phospholipids, sphingolipids, terpenes, steroids)

 

Drug development and drug behavior in the organism (explain basic principles using selected drugs)

1.      Sources of new drugs

2.      Optimization of drug structure

3.      Drug behavior in the body and its influence through structural modifications

4.      Physicochemical drug properties and their modification

5.      Non-covalent interactions between drugs and target structures