Subjects

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Clinical Pharmacology - FG50010

Title:	Clinical Pharmacology
Guaranteed by:	Department of Pharmacology (15-310)
Faculty:	Faculty of Medicine in Hradec Králové
Actual:	from 2021
Semester:	summer
Points:	0
E-Credits:	2
Examination process:	summer s.:
Hours per week, examination:	summer s.:15/15, C [HS]
Capacity:	18
Min. number of students:	5
4EU+:	no
Virtual mobility / capacity:	no
Key competences:
State of the course:	taught
Language:	English
Teaching methods:	full-time
Teaching methods:	full-time
Level:
Note:	course can be enrolled in outside the study plan enabled for web enrollment

Guarantor:	prof. MUDr. Stanislav Mičuda, Ph.D.
Comes under:	General medicine - ELECTIVE subjects
Incompatibility :	FA0110073
Pre-requisite :	FG10041

Examination dates SS schedule

Annotation -

Last update: Hana Kalhousová (06.02.2024)

Clinical pharmacology supports the rational use of drugs in humans to enhance the therapeutic effect and reduce side effects. Therefore, teaching this subject builds on the knowledge of basic pharmacology acquired during the study of the subjects Pharmacology I and II with the implication of evidence-based medicine principles. The student will be introduced to the possibilities of therapy optimization using: therapeutic monitoring, pharmacogenetics, bioindicators, pharmacoepidemiology, drug adherence, and analysis of pharmacotherapeutic complications. Pharmacotherapy for pain, heart failure, thromboembolic complications, cancer, and infectious diseases will be discussed. Practical teaching is oriented towards the use of acquired knowledge to solve specific pharmacotherapeutic situations that can be observed in clinical practice.

Entry requirements

Last update: Hana Kalhousová (06.02.2024)

Entry requirements: prerequisites: completed Pharmacology II.

Aim of the course

Last update: Hana Kalhousová (06.02.2024)

Outcomes (Clinical pharmacology):

The student acquires theoretical knowledge of the principles of clinical pharmacology.
The student will acquire practical skills in evaluating the effect of drugs and subsequent adjustment of pharmacotherapy to optimize the effect while minimizing side effects.
The student will be able to use specific drugs in selected clinical situations.

Requirements to the exam

Last update: Hana Kalhousová (06.02.2024)

Conditions for granting credit in pharmacology:

a) Attendance at classes

Participation in seminars and practical exercises is mandatory. One absence is tolerated (the reason does not need to be documented); late arrivals to classes will also be counted as absences if they are significant. In case of two absences, the student will be examined in detail on the issue of both missed practical exercises in order to receive credit. Due to three or more absences, the student will be tested for the entire semester or will be required to prepare reports on missed topics in order to receive credit. In case of absence within this extent, it is also necessary to provide official reasons and appropriate confirmations (e.g. from a doctor, from the office, etc.).

b) Worksheets

During the semester, in practical courses and seminars, students solve model clinical situations presented through worksheets or by the teacher's oral assignment. Students must submit written solutions to these assignments upon request.

c) Knowledge

At each practical course, a graded check of students' knowledge takes place in written or oral form. The grade point average received during classes in the semester must be less than or equal to 3.00 (absences do not affect the grade point average). Due to the grade point average > 3.00 - the student will be examined in the scope of the entire semester.

d) In the event of a forced transition to online teaching

Practical teaching will take place in a distance form through MS TEAMS using materials in MOODLE LFHK. Students will be required to have the cameras on for the possibility of checking their presence and activity. Repeated technical problems on the part of the student will be considered an absence. The main content of the practical teaching will be a moderated discussion and the solution of examples from clinical practice using written or oral assignments. Knowledge testing will take place continuously online orally, or in the form of a face-to-face credit test when the epidemiological situation allows it.

Syllabus

Last update: Hana Kalhousová (06.02.2024)

Teachers

Prof. Stanislav Micuda, M.D., Ph.D.
Assoc. Prof. Martin Štěrba, PharmDr., Ph.D.
Assoc. Prof. Jaroslav Chladek, M.Sc., Ph.D.
Jiri Grim, M.D., Ph.D.
Assoc. Prof. Miroslav Solař, M.D., Ph.D.

Lectures

1. Clinical oncology.
2. Clinical pharmacology of biological drugs.
3. Clinical pharmacology of heart failure.
4. Introduction. The role of genetic polymorphism.
5. Drug dosage in liver and kidney disease.
6. Dosage regimen prediction based on the pharmacokinetic principle: therapeutic drug monitoring (TDM) and its usage in pharmacotherapy.
6.1. Demonstration and practical exercises.
7. Adverse effects of drugs, Drug-drug interactions.
7.1. Overview, case reports.
8. Clinical pharmacology of anticoagulant agents.
8.1. Case reports.
9. Analgesics and antibiotics.
10. Drugs in pregnancy and breastfeeding.

Practical courses & seminars

Literature

Last update: Hana Kalhousová (06.02.2024)

Compulsory literature

Katzung BG, Trevor AJ: Basic and clinical pharmacology, 15th ed. 2021, ISBN-13: 9781260452310 (or the latest edition available)
Lectures in electronic form (https://moodle.lfhk.cuni.cz/)

Recommend literature

Gerard A. McKay (Editor), Matthew R. Walters (Editor), Neil D. Ritchie (Editor). Clinical Pharmacology and Therapeutics, 10th Edition, Wiley-Blackwell 2021, ISBN: 978-1-119-59995-1
Morris Brown, Pankaj Sharma, Fraz Mir, Peter Bennett. Clinical Pharmacology, Elsevier 2018, ISBN: 9780702073281