The teaching is a continuation of the subject Pharmacology I. and is focused on special chapters organized into topics grouped according to individual organ systems. Emphasis is placed on familiarization with the principles of clinical use of the drugs discussed. Specifically, it is an introduction to drugs used in the therapy of cardiovascular diseases, blood coagulation disorders, hyperlipidemia, diseases of the hormonal system, including the use of hormones in the role of drugs, metabolic diseases such as obesity and diabetes mellitus, diseases of the gastrointestinal tract, immune, infectious and cancer diseases. As part of the course, selected chapters on drugs affecting the central nervous system are repeated, and the issue of drug addiction is addressed. The superstructure area is then a set of factors that influence the body's reaction to the drug and condition the intra- and inter-individual variability of the body's response to standard treatment. In the end, chapters on dosage forms and drug prescriptions are discussed. Practical teaching is oriented towards the use of acquired knowledge to solve specific pharmacotherapeutic situations that can be observed in clinical practice.
Entry requirements: prerequisites: completed Pharmacology I.
Outcomes (subject Pharmacology II):
1. the student acquires theoretical knowledge of the special pharmacology of the organ systems being addressed, with emphasis on the practical use of drugs in specific clinical situations.
2. the student will acquire practical skills in prescribing drugs and evaluating the effect of drugs to optimize the results of therapy with the minimization of side effects.
3. the student will be able to identify drugs by name and describe their basic properties.
Requirements to the exam
Last update: Hana Kalhousová (21.08.2023)
Conditions for granting credit in pharmacology:
a) Attendance at classes
Participation in seminars and practical exercises is mandatory. One absence is tolerated (the reason does not need to be documented); late arrivals to classes will also be counted as absences if they are significant. In case of two absences, the student will be examined in detail on the issue of both missed practical exercises in order to receive credit. Due to three or more absences, the student will be tested for the entire semester in order to receive credit. In case of absence within this extent, it is also necessary to provide official reasons and appropriate confirmations (e.g. from a doctor, from the office, etc.).
b) Worksheets
During the semester, in practical courses and seminars, students solve model clinical situations presented through worksheets or by the teacher's oral assignment. Students must submit written solutions to these assignments upon request.
c) Knowledge
At each practical course, a graded check of students' knowledge takes place in written or oral form. The grade point average received during classes in the semester must be less than or equal to 3.00 (absences do not affect the grade point average). Due to the grade point average > 3.00 - the student will be examined in the scope of the entire semester.
d) In the event of a forced transition to online teaching
Practical teaching will take place in a distance form through MS TEAMS using materials in MOODLE LFHK. Students will be required to have the cameras on for the possibility of checking their presence and activity. Repeated technical problems on the part of the student will be considered an absence. The main content of the practical teaching will be a moderated discussion and the solution of examples from clinical practice using written or oral assignments. Knowledge testing will take place continuously online orally, or in the form of a face-to-face credit test when the epidemiological situation allows it.
Examination:
Credits from the subjects Pharmacology I and II are a condition for taking the exam. The exam starts with a test. The test is an integral part of every attempt, and its result is an important part of the classification. The test is focused on basic knowledge of individual topics and determines an overview of the field. If the student manages to achieve a result of 1 or 1- in the test and at the same time has an average grade from the intermediate tests in both the summer and winter semesters of 2 or less (assessed in each semester separately), he will draw only one question from general pharmacology. If this condition is not met, the student will draw one question from general pharmacology and one from special pharmacology. If the test result is worse than 3 during the first attempt, the exam is terminated with a "failed" result. If the test result is worse than 3 during the second or third attempt, it is possible to advance to the oral part of the exam, but it is necessary to give a convincing performance on both drawn questions.
Rules of behavior during final exams:
The aim is to provide fair and equal conditions in the final examination. Failure to follow these instructions will result in termination of the exam, and the student will receive a grade of 4 / FAIL.
• Students must leave all personal belongings only in the designated area in the examination room.
• The following items are not permitted in the exam room outside the designated area for personal belongings:
o Mobile phones – even when switched off
o It is the student's responsibility to confirm that their devices are OFF and NOT ON during the preparation for the examination or test.
o All clocks other than simple analog (time can be monitored on classroom wall clocks). Due to the increase in technologically advanced smartwatches, students can no longer have them on their wrists or desks.
o Other unauthorized electronic devices include, but are not limited to, laptops, tablets, calculators, MP3 players (such as iPods), personal digital assistants ("PDAs" such as Palm Pilot or Blackberry), electronic dictionaries, and smart glasses.
o Loose coats/sweaters/hoodies with pockets
o Eating for reasons other than health
o Headphones for reasons other than health (the student must inform the supervising employee of the department and the examiner of this fact in advance)
o Backpacks/wallets
o Pencil cases (clear plastic bags are fine), calculator cases
o Printed material, notes, or blank paper
• Students may not talk, whisper or exchange information in any way with another student.
A student is allowed to take a bottle of water. It must be in a clear, colorless bottle, and the label must be removed. After the question has been drawn, it is not allowed to leave the classroom where the exam is taking place. In an emergency, the student will be assigned an escort.
Syllabus
Last update: Hana Kalhousová (21.08.2023)
Lectures
The lectures will take place face-to-face in MS Teams in the form of "live" transmission, or an academic staff member will prepare a Powerpoint presentation with inserted voice comments. Video of the lecture will then be uploaded to our Moodle page. The presenting teacher will be online to answer questions during class time or will be available to students for consultations or questions about the lecture in another adequate way. The method of presentation will be up to the individual lecturer. The students will be informed about this in advance. The recorded lectures will be permanently available on the corresponding Moodle page.
Pharmacology of corticoid and thyroid homones. (Mičuda, 3)
Pharmacology of sexual hormones, osteoporosis. (Mičuda, 3)
Antibacterial drugs - general pharm., beta-lactams, vancomycine, macrolides, aminoglycosides.(Mičuda, 3)
Antibacterial drugs - tetracyclines, sulfonamides, quinolones, other ATBs. (Mičuda, 2)
Anticancer drugs - general pharmacology and overview of drugs. (Chládek, 2)
Practical courses & seminars
Lecturers
Prof. Stanislav Mičuda, M.D., Ph.D.
Assoc. Prof. Martin Štěrba, PharmD., Ph.D.
Assoc. Prof. Jaroslav Chládek, MSc., Ph.D.
Jolana Schreiberová, M.D., Ph.D.
PharmDr. Olga Lenčová, Ph.D.
1. Drug dependence and abuse, revision of CNS pharmacology - microlesson and seminar. 1.1. General pharmacology of drug dependence, drugs and agents inducing dependence. 1.2. Revision of CNS affecting drugs related to the topics (esp. hypnosedatives and opioids). 1.3. Test (Moodle).
2. Drugs used in altered states of hemostasis (bleeding and thrombosis) - seminar. 2.1. Basic and clinical pharmacology. 2.2. Therapy of thrombosis and monitoring of therapy with anticoagulants. 2.3. Test (Moodle).
3. Drugs acting on the gastrointestinal tract. Hypolipidemic drugs - microlesson and seminar. 3.1. Test (Moodle).
4. Antiasthmatics, histamin and antihistamines - microlesson and seminar. 4.1. Basic and clinical pharmacology. 4.2. Approach to asthma management. 4.3. Practical demonstrations: Handling different types of inhalers. 4.4. Test (Moodle).
5. CVS I: Cardiac glycosides, drugs affecting RAAS, diuretics - seminar. 5.1. Basic and clinical pharmacology. 5.2. Test (Moodle).
6. CVS II: Overview of pharmacological treatment of angina, hypertension and heart failure - seminar. 6.1. Basic and clinical pharmacology. 6.2. Test (Moodle).
7. Pharmacology of hormones - insulin and antidiabetics, corticoids - microlesson and seminar. 7.1. Test (Moodle).
8. Antibiotics I - seminar. 8.1. Beta-lactams, aminoglykosides, glycopeptides, clindamycin, chloramphenicol, macrolides. 8.2. Test (Moodle).
9. Antibiotics II - seminar. 9.1. Quinolones, sulphonamides, urinary tract antiseptics, antimycobacterial and antifugal drugs. 9.2. Test (Moodle).
10. Anticancer chemotherapy - microlesson and seminar. 10.1. Basic pharmacology of cytostatics. 10.2. Test (Moodle).
11. Factors influencing the response to a drug. 11.1. depending on the drug: physico-chemical features, route of administration, drug formulation, food 11.2. depending both on the drug and on the body: dose, repeated administration (accumulation, tolerance), coadministration with other drugs (synergism, antagonism), delayed effects 11.3. depending on the body: gender, age, genetic information, pathological state. 11.4. Demonstration: digoxin and lignocaine in kidney and liver failure. 11.5. Test (Moodle).
12. Basic information on pharmaceutical dosage forms, prescription writing - microlesson and seminar. 12.1. Test (Moodle) and credit.
Consultations with any teacher of the Department of Pharmacology are possible by prior arrangement.
Literature
Last update: Hana Kalhousová (21.08.2023)
Compulsory literature
Katzung BG, Trevor AJ: Basic and clinical pharmacology, 15th ed. 2021, ISBN-13: 9781260452310 (or the latest edition available)
Recommend literature
Rang HP, Ritter JM et al: Rang & Dale's Pharmacology. 9th ed., Churchill Livingstone Inc., New York, 2019. ISBN: 9780702074486 (or the latest edition available)
Whalen K: Lippincott Illustrated Reviews: Pharmacology 7th edition, Lippincott Williams and Wilkins, 2018. ISBN: 149638413X (or the latest edition available)
