Pathophysiology is a key "pre-clinical" subject in the medical curriculum, providing information about etiology (causes) and pathogenesis (development) of malfunctions of the human body during diseases. The first semester is devoted to description of general mechanisms of health disorders and their effects on body functions. Problems which accompany a lot of diseases like inflammation, hypoxia, disorders of internal body environment, pain etc. are instructed. Hematological, cardiovascular and respiratory diseases are still included in this first block. In practical classes students are instructed in registration of electrocardiogram and in evaluation of ECG pathological changes, also spirometry is performed and typical findings are discussed.
Requirements to the exam
Last update: Lenka Kořínková (14.09.2015)
Credit:
For credit, maximum one absence, passing of all written tests or oral examinations in seminars and practical classes and presentation of papers to given topics is required.
Examination:
Final exam is oral and includes one question in general pathophysiology and two questions in systemic pathophysiology. Obtaining of both credits (winter and summer term) is obligatory for the final exam.
Syllabus
Last update: Lenka Kořínková (14.09.2015)
Lecturers
Prof. Miroslav Kuba, M.D., Ph.D.
Prof. Zuzana Kubova, M.D., Ph.D.
1. Organism and Environment, Adaptation. 2. Health Versus Disease, Clinical and Biological /Somatic/Death. 3. Etiology and Pathogenesis. (Kuba 3)
6. Alterations in Fluid Volume. 7. Disorders of Osmolarity, Etiology and Pathogenesis of Edema. 8. Hyponatremia, Hypernatremia. (Kubova 3)
34. Control of Cardiac Function, Disorders of rhythm and conduction. 35. Ischemic Heart Disease. 36.Myocardial Infarction and its Complications. 37. Valvular Heart Disease. 38. Congenital Heart Defects. (Kuba 3)
1. Introduction to practical classes. Disorders of acid-base balance. Hypokalemia, Hyperkalemia.
2. Neoplasia,Neoplasm-Host Interaction (Effects). TEST - homeostasis disorders
3. Stress, General Adaptation Syndrome, Psychosomatic Diseases.
9. Pathophysiology of Pain. TEST - haemostasis disorders
10. Thermoregulation. Etiopathogenesis of fever.
Practical courses
4. ECG I - description
5. ECG II - description. TEST - disorders of calcium metabolism
6. ECG III - practice
7. ECG IV - practice, self-ECG recordings.
8. ECG V - TEST
11./12. Bicycle ergometry - adaptation of the cardio-vascular system to a physical load. 1/2 group
12./11. Computer Spirometry - recordings and evaluation. 1/2 group
13. Anemias - Etiology and Pathogenesis, Functional consequences, Compensation; Microscopic findings in peripheral blood.
Literature
Last update: Lenka Kořínková (14.09.2015)
Compulsory literature
M. Kuba, Z. Kubova Pathophysiology- Basic overview for medical students. 1st. ed., The Karolinum Press, 2006. ISBN 80-246-1190-2
S. A. Price, L. M. Wilson Pathophysiology-Clinical Concepts of Disease Processes. 5th ed., Mosby - Year Book Inc., 1997. ISBN 0-8151-6621-4. (4th edition from 1992 is also acceptable)
Recommend literature
C. M. Porth Pathophysiology-Concepts of Altered Health States. 5th ed., J.B. Lippincott Comp. Philadelphia, 1998. ISBN 0-397-55413-3
S. J. McPhee et al. Pathophysiology of Disease (An Introduction to Clinical Medicine). 3rd ed., Lange Medical Book, 1997. ISBN 0-8385-8160-9
L. S. Lilly Pathophysiology of Heart Disease: a collaborative project of medical students and faculty. 2nd ed., Williams and Wilkins Baltimore, 1998. ISBN 0-683-30220-5
J. Ali, W. R. Summer, M. G. Levitzky Pulmonary Pathophysiology. 1st ed., McGraw-Hill New York 1999. ISBN 0-07-062170-5
L. Borska et al. EKG Desatero. 1st ed., MSD Brno -COPY 2006. ISBN 80-86633-52-7
