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Course, academic year 2019/2020
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Physiology I - FD10019
Title: Physiology I
Guaranteed by: Department of Physiology (15-130)
Faculty: Faculty of Medicine in Hradec Králové
Actual: from 2018 to 2019
Semester: winter
Points: 0
E-Credits: 7
Examination process: winter s.:
Hours per week, examination: winter s.:33/72, C [HS]
Capacity: unlimited
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
Key competences:  
State of the course: taught
Language: English
Teaching methods: full-time
Teaching methods: full-time
Level:  
Guarantor: prof. MUDr. Michaela Adamcová, Ph.D.
Incompatibility : FZ10017
Interchangeability : FA0203037, FZ10017
Is co-requisite for: FD50006, FD10020
Is incompatible with: FZ10017
Is interchangeable with: FZ10017
In complex pre-requisite: FD10048, FD10049, FD10050, FD10051, FD10053, FD10054, FD10055, FD10056, FD10057, FD10058, FD10060, FD10061, FD10062, FD10063, FD10064, FD10065, FD10066, FD10067
Examination dates   Schedule   
Annotation
Last update: Ivana Altmannová (18.09.2020)
To gain a good theoretical knowledge in following fileds of medical physiology: regulation of body functions, haematology, immunology, general neurophysiology (transport of ions across cell membrane, resting membrane and action potential), myology, central nervous system (spinal cord reflexes, control of posture and movement, the autonomic nervous system, function of single parts of CNS, sleep and wakefulness, higher nervous functions), cardiovascular system. To gain basal practical skill in haematological laboratory examination, in physical examination of the cardiovascular system, and in investigation of sense functions. Using computer simulation to demonstrate basic electro-physiological principles. To learn how to gain scientific information.
Requirements to the exam
Last update: Ivana Altmannová (18.09.2020)

Obtaining a credit grade

Credit will be given to the students, who fulfil the attendance requirements and have passed the examinations in each of the individual physiology system in that semester. Each semester that contains physiology has a single credit, i.e. there are two credits.

 

Attendance:

Students are required to attend all practical (laboratory) classes; absence due to illness has to be supported with a doctor,s certificate. The number of legitimated absences may not exceed 15 % of all practical classes. If more that 15 % laboratory class per term are missed or in case of unexcused absence the situation will be supervised by the Head of the Department of Physiology. Students are not allowed to leave practical before it is officially finished by the teacher. Leaving practical earlier will be considered as unexcused absence.

 

Tests:

At the end of laboratory classes in each system, a seminar will be held during which the students will be tested on that system. The test will be in the form of a multiple choice questionnaire. Those students who fail the test will take 1st correction test (the date will be announced in advance). There will be dates for 2nd correction at the end of winter or summer semester respectively. Students who give sufficient explanation why they could not take the test on regular date will take the test on date of 1st correction test. If, for these reasons, the student fails to consume all terms, a substitute term will be announced at the end of the semester.  Third correction test will be on day of alternative practical exam (see Practical Exam) in the form of oral exam by a commission.  In order to receive a credit, student must score at least "good" in all tests.

Basic knowledge of recording and evaluation of ECG will be tested too. In order to receive a credit, student must score at least "good" in this test. The same rules mentioned above are applied for this test.

 

Practical examination:

In the final laboratory class of the summer semester students will undertake a practical laboratory examination. For admission to the practical examination student must have credit in both winter and summer term. The timing of the practical examination is fixed and only in very exceptional circumstances and with the permission of the Head of the Department of Physiology, an alternative date can be set for an individual student/s. Absence on the practical examination due to illness has to be supported with a doctor's certificate. The alternative date is also for students who failed 2nd correction of one or more written test(s) and thus they cannot receive a credit. When attending the laboratory examination every student must produce the records and data from all the practical classes. Students select a question that will be one of the practical classes that the student has undertaken during the entire physiology course. In addition to demonstrating this practical technique(s) student will be expected to understand the background information which formed part of the original laboratory practical exercise. The practical exam has only one attempt. In the overall grade awarded in the final examinations, a result recorded in the practical exam will be taken into account.

 

Final examination in physiology

For admission to final examination students must receive credits in both winter and summer term, complete practical examination and sign up for final examination (SIS system)   The examination comprises an introductory written test, then oral exam follows. Re-examination comprise only the oral part. The number of announced dates for a regular term take into account the total number of students. More dates will be for the 1st and 2nd retake and will be anounced with regard to the current requirements.

Use of electronic devices (cell phones, tablets, notebooks etc.). unauthorized materials or communication with other students is strictly prohibited. After selecting final exam question it is not allowed to leave the room and when necessary an escort will be provided. In case of failure to comply with these rules, students will be classified "failed". Registration and re- registration can be done only through SIS. Detailed information on the format of this examination will be posted on the bulletin board t the end of the summer term.

Syllabus
Last update: Ivana Altmannová (10.09.2020)

Lecturers

  • Assoc. Prof. Michaela Adamcová, M.D., Ph.D.
  • Prof. Dr. Milan Holeček, M.D., Ph.D.
  • Assoc. Prof. Halka Lotková, M.D., Ph.D.

 

30. 9. 2019      Introduction to physiology (homeostasis and its regulation). (Adamcová 1)

30. 9. 2019      Cell membrane (cell communication, transport of substances through cell membrane). (Adamcová 1)

30. 9. 2019      Body fluid compartments. Composition of body fluids, measurement of body fluid volumes. Function of blood. Physical constants of blood. Plasma.  (Adamcová 1)

 2. 10. 2019      Red blood cells. Hemolysis. Sedimentation of red cells. (Adamcová 1)

 2. 10. 2019      Haemoglobin. Regulation of red blood cell production - the role of erytropoietin. Essential substances required for erythropoiesis. (Adamcová 1)

 2. 10. 2019      White blood cells. Regulation of white cell production. (Adamcová 1)

 4. 10. 2019      Blood groups, blood transfusion. (Adamcová 1)

 4. 10. 2019      Hemostasis (vessel reaction, importance of platelets, blood clotting, anticlotting mechanisms, anticoagulant drugs). (Adamcová 2)

 9. 10.2019       Immunology. Clasification of immune mechanisms (non-specific defence mechanisms, specific immune mechanisms, humoral and cell-mediated). Interactions between non-specific and specific immune mechanisms. Ontogenesis of immunity. Vaccination and passive immunity. 

                        Vaccination and pasive immunity. Inflammation, allergy, auto-immunity. (Holeček 3)

20. 11. 2019     Spinal cord reflexes - proprioceptive stretch and tendom reflexes, exteroceptive reflexes, the role of muscle spindle and of gamma system, reciprocal innervation. (Holeček 1)

20. 11. 2019     Control of posture and movement - motor functions of spinal cord, cerebellum, basal ganglia, descendent part of reticular formation and brain. (Holecek 2)

27. 11. 2019     Autonomic nervous system. (Holeček 1)

27. 11. 2019     Regulation of visceral function - the role of spinal cord, medulla oblongata, hypothalamus and limbic system in control of vegetatitve functions (vital centers, vomiting, hunger, thirst, sexual reactions, body temperature). Relation of hypothalamus to pitutairy gland. (Holeček 1)

27. 11. 2019     The reticular activating system, spontaneous and evoked electric brain activity (EEG and evoked potentials). Sleep and wakefulness. (Holeček 1)   

  4. 12. 2019     Blood - brain barrier cerebrorspinal fluid. Mtabolism of the brain. (Holeček 1)

  4. 12. 2019     CNS, inborn and acquired forms of behaviour, learning and memory. Emotion. (Lotková 2)

11. 12. 2019     Specific characteristics of CNS in human (speech, hemispheric dominance, prefrontal lobes), types of personality. (Lotková 1)

11. 12. 2019     Action potential in cardiac muscle. Electrical and mechanical properties of cardiac muscle, conductive system. (Adamcová 2)

18. 12. 2019     Contraction of cardiac muscle. Excitation-contraction coupling. Homeostasis of calcium. Mechanical properties of heart, metabolism of cardiac muscle. (Adamcová 1)

18. 12. 2019     The heart as a pump. The cardiac cycle. The main hemodynamic events associated with the cardiac cycle. Heart sounds. ECG. (Adamcová 1)

18. 12. 2019     Cardiac output - method of measurement, regulation of output. (Adamcová 1)

   8. 1. 2020     Dynamics of blood flow. Flow, pressure, and resistance. Laminar and turbulent flow. Poiseuille-Hagen formula. Critical closing pressure. Law of Laplace. (Adamcová 2)

   8. 1. 2020     Function of vessel endothelium. Production of interstitial fluid, lymph. (Adamcová 1)

 15. 1. 2020      Local and systemic cardiovascular regulatory mechanisms. Cardiac enervation. The reflex mechanisms for maintaining normal arterial pressure. (Adamcová 2)

 15. 1. 2020      Circulation through special regions (tooth pulp cerebral circulation, splanchnic, lung circulation, circulation of the skin, and of muscles). (Adamcová 1)

 

Practical courses & seminars

Lecturers

  • Assoc. Prof. Michaela Adamcová, M.D., Ph.D.
  • Prof. Zuzana Červinková, M.D., Ph.D.
  • Prof. Milan Holeček, M.D., D.Sc.
  • Assoc. Prof. Otto Kučera, M.D., Ph.D.
  • Assoc. Prof. Halka Lotková, M.D., Ph.D.
  • David Rychtrmoc, M.D., Ph.D.
  • Pavla Staňková, Mgr., Ph.D.
  • Václav Šafka, M.D., Ph.D.

 

Seminars

  1. Test (MCQ) and seminar - hematology.
  2. Test (MCQ) and seminar - immunology.
  3. Test (MCQ) and seminar - general neurophysiology and myology
  4. TEST ECG.

Practical courses

  1. Introduction to practical laboratories. Rules of safety work in laboratories. Rules of blood handling and blood sampling.
  2. Counting of red blood cells.
  3. Hemoglobin.
  4. Hemolysis. Testing of fragility of red blood cells.
  5. Counting of platelets. Investigation of capillary resistance. Investigation of bleeding time.
  6. Packed cell volume (PCV - Hematocrit). Specific gravity of blood. Red blood cell sedimentation. Calculation of red blood cell indices.
  7. Determination of clotting time (Lee-White), APTT, prothrombin time.
  8. How to gain scientific information.
  9. Testing for blood grop and Rh factor.
  10. Counting of white blood cells.
  11. Classification of white blood cells (differential count).
  12. Computer simulation of action potential (PC program "AXONLAB").
  13. Basic neurological examination - proprioceptive and exteroceptive reflexes.
  14. Computer modelling of neuromuscular transmission (PC program "CONDUCT"). Mechanical properties of muscle - recording of single twich, summation, superposition, and tetanus (videofilm).
  15. Visual acuity. Astigmatism. Color vision.
  16. Ophthalmoscopy. Stereoscopic vision. Perimetry.
  17. Subjective and objective examination of hearing. Investigation of vestibular functions.
  18. Physical examination of cardiovascular system. Determination of arterial blood pressure.
  19. Harvard step test.
  20. Computer simulation of regulation of blood pressure (PC programme "PHARMATUTOR").
  21. Credit.
Literature
Last update: Ivana Altmannová (18.09.2020)

Compulsory literature

  1. Hall: Guyton and Hall Textbook of Medical Physiology, Elsevier 2016 (e-book)
  2. Cervinkova et al.: A Manual in Laboratory Studies in Physiology (obtained at the 1st practical class)

 

Recommended literature

  1. Silbernagl, Despopoulos: Color Atlas of Physiology, Georg Thieme Verlag, 2015 (e- book)
  2. Barrett: Ganong´s Review of Medical Physiology, Lange Medical Books, 2010

     

 

 

 

 

 
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