SubjectsSubjects(version: 945)
Course, academic year 2014/2015
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Biology I - FD10009
Title: Biologie I
Guaranteed by: Department of Medical Biology and Genetics (15-120)
Faculty: Faculty of Medicine in Hradec Králové
Actual: from 2011 to 2014
Semester: winter
Points: 0
E-Credits: 4
Examination process: winter s.:
Hours per week, examination: winter s.:15/30, C [HS]
Capacity: unlimited
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
Key competences:  
State of the course: taught
Language: English
Teaching methods: full-time
Teaching methods: full-time
Level:  
Guarantor: prof. MUDr. RNDr. Miroslav Červinka, CSc.
Incompatibility : FZ10009
Interchangeability : FA0201045, FZ10009
Is co-requisite for: FD10010
Is incompatible with: FZ10009
Is interchangeable with: FZ10009
Examination dates   Schedule   
Annotation
Last update: Marcela Laláková (21.09.2016)
Definition of life, organisation of living systems. Molecules in cells, structure and function of proteins and nucleic acids, Cell theory, prokaryotic and eukaryotic cells. The cell nucleus, organisation of DNA, chromosomes. DNA replication and repair. Transcription and translation of genetic information, RNA processing, posttranslational modification. The cellular membranes ? structure and function, transport across biomembranes, cell membrane fusion. The endoplasmic reticulum, the Golgi apparatus. The mitochondrion, production of ATP. The cytoskeleton Cell growth and cell division Regulation of cellular functions Malignant cell transformation, Interaction of cells with the environment. Cell death, necrosis, apoptosis.
Requirements to the exam
Last update: Marcela Laláková (21.09.2016)

 

I.  General

 

 ·      Attendance at lectures and practical classes is mandatory.

 

·      Practicals begin at 3,00 p.m. and student is required to be in his seat 5 minutes before the beginning of the class.

 

·      Each student is allowed one absence (medically excused) from one practical class. Medical excuse or any other valid official reason is required. A second absence will constitute reason for dismissal.

 

·      A clean, dry pair of indoor shoes (not boots) is required. If a student does not have clean shoes, he can purchase disposable shoe covers. Backpacks and coats must be stored away from the working area.

 

·      White lab coats must be worn for all practical classes.

 

·      No eating, drinking or smoking in the laboratory at any time.

 

·      In case of injury, report it immediately to the instructor.

 

·      The clean-up procedure for each practical class will be explained at the beginning of the course.

 

·      Deadline for sending via email a full-text medical article plus its Medline (Current Contents) record is December 5th 2014. The topic of the article may be used in the final semestral presentation.

 

 II. Credit

 

The credit for Medical Biology practical classes in winter semester consists of:

 

·      Completed workbook. Workbook presented during credit session must have an appropriate external form; i.e. be clean, intact as it has status of official document. In case of any workbook damage or loss, the student has to acquire a new one from the department against financial compensation.

 

·      Final test with minimal scoring grade of 75 % (there is one final test and in case of its failure, there are two more retakes).

 

·      Bibliographic record plus fulltext of selected biomedical article (winter term)

 

·      Presentation of selected topic (winter term)

 

Cheating during any form of biology exam (credit test and oral examination) including preparatory period is not tolerated! Use of any electronic devices (cell phones, tablets, notebooks, phablets etc.), unauthorized materials or communication with other students in these instances is strictly prohibited! After selecting final exam questions it is not allowed to leave the room and when necessary an escort will be provided. In case of failure to comply with these rules, student will be classified "failed".

Appointments for respective credits are scheduled to winter examination period (January 19th 2015 - February 15th 2015) and summer examination period (June 1st 2015 - June 30th 2015) and during September (1st - 22th 2015), each week on Thursdays from 2 to 3 pm only.

Each student has to sit credit at least once in winter examination period. Generally, in case of failure in credit (i.e. final test or incomplete manual), the next possible chance is after one week!!!!

The students who seek the exemption from practical classes in medical biology and genetics have to submit their request before the start of practical classes. Their request must be accompanied by a detailed syllabus of biology course they had completed which will be evaluated by the head of the department of medical biology and genetics.

 

 

Syllabus
Last update: Marcela Laláková (21.09.2016)

Lecturers

  • Prof. Dr. Miroslav Cervinka, M.D., Ph.D.

Lectures  

 

October 10              

·         Definition of life, organisation of living systems.

·         Cell theory - prokaryotic and eukaryotic cells.

·         Chemical composition of cells, structure and function of proteins.

               

October 24                

·         Structure and function of nucleic acids.

·         The cell nucleus, organisation of DNA, chromosomes.

·         DNA replication, repair and recombination.

               

October 31

·         Transcription and translation of genetic information, exons, introns, RNA processing, posttranslational modification.

               

November 7           

·         The cellular membranes - structure and function, ionic and molecular transport across biomembranes, osmosis, cell membrane fusion.

·         The endoplasmic reticulum, the Golgi apparatus.

               

November 14         

·         The mitochondrion, respiratory chain, electron transport system, production of ATP, chemiosmotic hypothesis.

·         The cytoskeleton (microtubules, microfilaments, intermediate filaments), cell motility, movement of organelles, cellular motors.

 

 

Practical courses & seminars

Lecturers

 

  • Prof. Dr. Emil Rudolf, Ph.D.
  • Dr. Veronika Hanušová, Ph.D.

Practical courses

 

6. 10.     1.            Microscopic techniques I.

                1.1          General terms and conditions of the biology course

                1.2          Size estimation

                1.3          Permanent mount of cells cultivated in vitro

                1.4          Vital staining

                              

13. 10.   2.            Microscopic techniques II.

                2.1          Wet mount of buccal cells

                2.2          Native mount of cultured cells

                              

20. 10.   3.            Cellular membranes - osmotic phenomena

                3.1          PEG stimulated fusion

                3.2          Osmotic changes in erythrocytes after the treatment with anisotropic solutions

                3.3          Plasmolysis in plant cell (Elodea densa)

                              

27. 10.   4.            Cell motility

                4.2          Cyclosis in plant cells (Elodea densa)

                4.3          Amoeboid movement

                4.4          Flagellar movement

                              

3. 11.     5.            Cell cultures in biomedicine (seminar)

                5.1          Cell and tissue culture techniques

                              

10. 11.   6.            Information sources and their relevance in biomedicine (seminar)

                6.1          Scientific information in biomedicine - the structure of scientific article

                6.2          In vitro tests used for cytotoxicity assays - dental applications

                              

24. 11.   7.            Cell death - scientific methodology

                7.1          Permanent mount of tumor cells treated with cytostatic drug

                              

1. 12.     8.            Cell cycle and cell division

                8.1          Mitosis in permanent mounts of plant cells

                8.2          Mitosis in animal cell cultures

                8.3          Mitotic index and particular phases of mitosis

                              

8. 12.     9.            Advances in biosciences (seminar)

                9.1          Student presentations (biodentistry oriented)

                              

15. 12.   10.          CREDIT

                10.1       Final test

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Literature
Last update: Marcela Laláková (21.09.2016)

Compulsory literature

  1. B. Alberts et al. Essential Cell Biology. An introduction to the molecular biology of the cell. Garland Publishing, Inc. New York & London, 1998. ISBN 0-8153-2971-7
  2. M. Connor et al. Essential Medical Genetics. 5th ed., Blackwell Science Ltd., 1997. ISBN 0-632-04158-7
  3. Nussbaum, McInnes, Willard Thompson and Thompson Genetics in Medicine. 6th ed. revised reprint, Saunders, 2004. ISBN 0-7216-0244-4 
  4. Handouts and other materials provided by the Dept. of Medical Biology and Genetics
  5. Homepage of the Dept. of Medical Biology and Genetics
  6. Lectures and recommended literature according to the list of lectures

 

 
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