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Infectious diseases- LF UK v Plzni, General medicine, course 4 since.pdf | Infectious diseases- LF UK v Plzni, General medicine, course 4 since | Jarmila Šindelářová |
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Last update: Jarmila Šindelářová (22.09.2023)
Infectious diseases of GIT. Differential diagnosis of diarrhea. Acute and chronic viral hepatitis, up-to-date therapeutic recommendation. Antibiotic treatment in clinical practice. Exanthematic infectious diseases. Differential diagnosis of lymphadenopathy. Neuroinfections (bacterial meningitis, viral meningitis, differential diagnosis of meningeal features). Sepsis, septic shock. Immunity disorders and infections. Respiratory tract infections. AIDS. <br> <br> |
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Last update: Jarmila Šindelářová (24.10.2023)
The obligatory literature: Mandal, B.K., Wilkins,E.G.L., Dunbar,E.M., Mayon-White,R.T.: Infections Diseases. Oxford: Blackwell 2004 Hobstová,J. et al.: Infections Diseases. Praha Karolinum 2012 The recommend literature: Mandell, G.L., Bennett, J.E., Dolin, R.: Mandell, Douglas and Bennett´s PRINCIPLES and PRACTICE of INFECTIOUS DISEASES, 9th edition 2019, 4176 pp. ISBN: 0323482554 Materials for lessons in Moodle |
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Last update: Jarmila Šindelářová (29.11.2023)
Completion of the practical and theoretical parts with the possibility of one absence. Replacement of missing practices will be possible by agreement of the teacher. In the 2023/2024 school year, teaching at the Department of Infectious Diseases and TM will take place in person. Full-time teaching will take place at KINCM (Building No. 2 of the University Hospital Bory), in individual departments and in the library according to the schedule. The in-person exam in infectious medicine consists of a test (to be done on a PC) and an oral exam - by pulling out 2 questions, according to the published list. Preparation time approx. 15 min. For the exam, the student must have writing utensils. During the exam, the student must not have a mobile phone and other unauthorized aids with him/her. The test, including the oral exam, takes place at the INF Library. Teaching and exams will take place according to the usual anti-epidemic rules.
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Last update: Jarmila Šindelářová (24.10.2023)
The syllabus: Lesson I Gastrointestinal diseases of infectious origin Pathophysiology of gastrointestinal diseases (osmotic, inflammatory, secretory mechanisms of diarrhoea) Incidence and epidemiology of infectious gastroenterites Infectious gastroenteritis of viral and bacterial origin and foodborne toxigenic diarrhoea (clinical course, diagnosis, therapy, prophylaxis) Differential diagnosis of infectious and non- infectious diarrhoea Complications of infectious diarrheal diseases Clinical picture, epidemiology, pathophysiology, complications, therapy, prophylaxis of Salmonellosis, Salmonella typhi and paratyphi, Cholera, E.coli gastroenteritis, Campylobacteriosis, Yersinia enterocolitica, Shigellosis, pseudomembranous enterocolitis, Rotavirus, Adenovirus, Norwalk virus gastroenterites and other viral gastroenterites, foodborne toxigenic diarrhea Hemolytic-uremic syndrome Aspects of prophylaxis of infectious diarrhea (vaccination)
Lesson II Infectious inflammatory diseases of the liver Pathophysiology of viral hepatites Incidence and epidemiology of viral hepatites Acute viral hepatitis A - pathophysiology, epidemiology, clinical course, diagnosis (laboratory and serologic markers), therapy, prophylaxis specific and non-specific Acute viral hepatitis B - pathophysiology, epidemiology, clinical course, diagnosis (laboratory and serologic markers), therapy, prophylaxis specific and non-specific Acute viral hepatitis C - pathophysiology, epidemiology, clinical course, diagnosis (laboratory and serologic markers) therapy, possibility of prophylaxis Viral hepatitis D - pathophysiology, epidemiology, clinical course, diagnosis (laboratory and serologic markers), therapy, possibility of prophylaxis Acute viral hepatitis E- pathophysiology, epidemiology, clinical course, diagnosis (laboratory and serologic markers) , therapy, prophylaxis Viral hepatites G, F, TTV - new causes of viral hepatites? Complications and sequelae of acute viral hepatites Differential diagnosis of acute hepatites (infectious and non-infectious origin) Chronic hepatitites B and C - incidence, clinical picture, laboratory and serologic markers, possibility of therapy and prophylaxis nowadays Reye´s syndrome
Lesson III Exanthematic diseases Types of exanthems commonly, pathogenesis Exanthematic diseases of bacterial and viral origin Scarlet fever – epidemiology, pathogenesis, clinical course, diagnosis, therapy, and differential diagnosis Toxic shock syndrome – history, epidemiology, pathogenesis, clinical course, diagnosis, therapy Kawasaki syndrome – history, epidemiology, pathogenesis, clinical course, diagnosis, therapy Rubella – epidemiology, pathogenesis, clinical course, diagnosis, differential diagnosis, complications, rubella in pregnancy, prophylaxis Measles – epidemiology, pathogenesis, clinical course, diagnosis, complications, differential diagnosis, measles and immunity of organism, prophylaxis Varicella (Chickenpox) – epidemiology, pathogenesis, clinical course, diagnosis, differential diagnosis, therapy, complications, varicella in pregnancy, varicella and immunodeficiency, prophylaxis Herpes zoster – epidemiology, pathogenesis, clinical course, diagnosis, therapy Megalerythema infectiosum – epidemiology, pathogenesis, clinical course, diagnosis, differential diagnosis, therapy, complications, megalerythema infectiosum in pregnancy Exanthema subitum (Roseola infantum)– epidemiology, pathogenesis, clinical course, diagnosis, therapy, complications
Lesson IV Lymphadenopathy Occurrence of lymphadenopathy commonly, quick diagnosis is necessary Viral causes of lymphadenopathy: Adenovirus – epidemiology, clinical course, diagnosis, therapy Infectious mononucleosis /virus Epstein-Barr, cytomegalovirus/ - epidemiology, pathogenesis, clinical course, diagnosis, therapy, complications Parotitis epidemica (Mumps) – epidemiology, pathogenesis, clinical course, therapy, complications, therapy if complications, prophylaxis Rubella, measles – clinical course exanthematic diseases Gingivostomatitis herpetica (Aphthous stomatitis) – epidemiology, pathogenesis, clinical course, therapy, differential diagnosis
Bacterial cases of lymphadenopathy: Infections of streptococci – angina, lymphadenopathy – epidemiology, pathogenesis, clinical course, diagnosis, therapy, complications Infections of staphylococci – angina, lymphadenopathy, bacterial parotitis – epidemiology, pathogenesis, clinical course, diagnosis, therapy, complications Tularaemia – history, epidemiology, pathogenesis, clinical course, types of tularaemia, diagnosis, therapy, complications Diphtheria – epidemiology, pathogenesis, clinical course, diagnosis, therapy, complications, prophylaxis Listeriosis – epidemiology, pathogenesis, clinical course, diagnosis, therapy, listeriosis in immunodeficiency Yersiniosis – epidemiology, pathogenesis, clinical course, diagnosis, therapy
Parasitic cause of lymphadenopathy: Toxoplasmosis – history, epidemiology, pathogenesis, clinical cause, diagnosis, therapy, toxoplasmosis in pregnancy, toxoplasmosis in immunodeficiency
Lesson V Parasitic diseases Malaria – history, epidemiology, pathogenesis, occurrence of malaria in the world, prophylaxis Types of malaria, clinical course, diagnosis, therapy, complications Amoebosis, giardiosis, echinococcosis, teniarhynchosis, hymenolepiosis, trichinosis (trichinellosis), ankylostomosis, askaridosis, enterobiosis, toxocarosis – etiology, epidemiology, clinical course, diagnosis, therapy, prophylaxis
Lesson VI Infections of the nervous system – bacterial meningitis Epidemiology. Ethiology. Clinical features. Diagnostic approach. Laboratory investigations, CSF features, serological tests, CT, MRI. Differential diagnosis. Treatment. Prognosis. Prevention Acute meningitis – pyogenic: haemophilus meningitis, pneumococcal meningitis, meningococcal infection. Neonatal meningitis Posttraumatic meningitis Complications of meningitis. Brain abscess Listeriosis and Listeria meningitis Tuberculous meningitis Fungal and parasitic infections of CNS (Cryptococcal meningitis, Toxoplasmosis) Septicaemia. Septic shock
Lesson VII Infections of the nervous system – aseptic meningitis Viral meningitis and encephalitis /HSV1, 2, VZ, EBV, CMV, AD, PA, enteroviral, TBE Postinfective and postvaccination encephalitis Parotitis epidemica (Mumps) and complications (CNS). Encephalitis herpetica Poliomyelitis and other enteroviral infections. Polio-like illness. Guillain - Barre syndrome Polyneuritis Tick borne infections /TBE, Lyme disease (borreliosis), ehrlichiosis, rickettsiosis, tularaemia/ Leptospirosis Slow viral infections of the CNS (spongiform encephalopathies) Rabies. Wound septicaemia (P. multocida) Botulism Tetanus
Lesson VIII Respiratory tract infections
Herpesvirus infections (HSV-1, HSV-2), Chickenpox and herpes zoster Influenza, parainfluenza, other viral infections of respiratory tract: RS virus, adenovirus, enterovirus, rhinovirus, acute obstructive laryngitis /croup/ Mycoplasmal and chlamydial infections /psittacosis, ornithosis/ Bacterial respiratory tract infections (Haemophilus influenzae infections, Pertussis and whooping cough syndrome). Actinomycosis Anaerobic infections
Lesson IX AIDS AIDS as a consequence of HIV infection History, epidemiology, pathogenesis, clinical pictures of various stages of HIV/AIDS, opportunistic infections and tumours associated with AIDS, laboratory and serological diagnosis, differential diagnosis, complications, advances in the treatment of HIV-infection (cART, HAART), vaccines, HIV and society. Fungal infections. New herpetic viruses. Infections in immunocompromised people. Opportunistic infections
Literature recommended for students: Mandal, B.K., Wilkins, E.G.L., Dunbar, E.M.,Mayon-White,R.T.: Infections Diseases. Oxford:Blackwell 2004 Hobstová,J. et al.: Infections Diseases. Praha Karolinum 2012 Mandell, G.L., Bennett, J.E., Dolin, R.: Mandell, Douglas and Bennett´s PRINCIPLES and PRACTICE of INFECTIOUS DISEASES, 9th edition 2019, 4176 pp. ISBN: 0323482554
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