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Course, academic year 2023/2024
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Pathological Physiology I. - EAP0102090
Title: Pathological Physiology I.
Guaranteed by: Ústav patologické fyziologie (14-90)
Faculty: Faculty of Medicine in Pilsen
Actual: from 2022
Semester: summer
Points: 3
E-Credits: 3
Examination process: summer s.:
Hours per week, examination: summer s.:3/3, C [HT]
Capacity: unlimited / unlimited (unknown)
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
Key competences:  
State of the course: taught
Language: English
Teaching methods: full-time
Teaching methods: full-time
Level:  
For type:  
Note: deregister from the credit exam date if a requisite was not fulfilled
Guarantor: doc. MUDr. Jan Cendelín, Ph.D.
MUDr. Karel Blahna, Ph.D.
MUDr. Jan Barcal, Ph.D.
Teacher(s): MUDr. Jan Barcal, Ph.D.
MUDr. Karel Blahna, Ph.D.
doc. MUDr. Jan Cendelín, Ph.D.
doc. MUDr. Karel Ježek, Ph.D.
Mgr. Štěpán Kápl
Ing. Pavel Klein, Ph.D.
Ing. Zuzana Petránková, Ph.D.
MUDr. Zdeňka Purkartová, Ph.D.
Mgr. Jan Tůma, Ph.D.
Attributes: Povinné předměty pro Všeobecné lékařství
Incompatibility : EA0106014
Pre-requisite : EAP0101020
Interchangeability : EA0106014
Is pre-requisite for: EAP0103090
Is interchangeable with: EA0106014
Annotation -
Last update: doc. MUDr. Jan Cendelín, Ph.D. (26.09.2023)
The content of the subject pathological physiology I is general pathophysiology and part of special pathophysiology. General pathophysiology deals with the general principles of origin, development and course of diseases and pathological conditions and pathological phenomena of a general nature. The subject of special pathophysiology is the etiology and pathogenesis of diseases and disorders of specific organs, organ systems and particular diseases. Practical skills related to basic medical procedures and their pathophysiological aspects in the context of theoretical knowledge are also taught. Prerequisites are knowledge from the fields to which pathological physiology follows, i.e., anatomy, histology, embryology, biology, genetics, chemistry and biochemistry, biophysics, physiology and microbiology. The subject of pathological physiology I forms an integral complex with the follow-up subject pathological physiology II, the content is interrelated and complementary.
Entry requirements -
Last update: doc. MUDr. Jan Cendelín, Ph.D. (26.09.2023)

For the practical exercises, the student must be theoretically prepared for the topic of the given class and is obliged to acquaint himself with the guideline for the given experiment or task (see study literature). Students, who did not attend the class in time, will be not admitted to the class with the sanction of absence.

 

Prerequisites are knowledge from the fields to which the subject pathological physiology follows, i.e. anatomy, histology, embryology, biology, genetics, chemistry and biochemistry, biophysics, physiology and microbiology.

Course completion requirements -
Last update: doc. MUDr. Jan Cendelín, Ph.D. (08.02.2024)

Conditions for the credit – pathological physiology I:

 

1. Active attending practical exercises – 2 absences per semester are allowed.

For the practical exercises, the student must be theoretically prepared for the topic of the given class and is obliged to acquaint himself with the guideline for the given experiment or task (see study literature). Prerequisites are knowledge from the fields to which the subject pathological physiology I follows, i.e. anatomy, histology, embryology, biology, genetics, chemistry and biochemistry, biophysics, physiology and microbiology. Students, who did not attend the class in time, will be not admitted to the class.

 

2. Submitting of correctly elaborated protocols of all experiments and practical exercises to the teacher, who assesses their correctness and confirms them as fulfilled, or returns them for revision.

 

The conditions of the credits for students having an individual study plan, who enrolled pathological physiology II for the second time, will be appointed individually in dependence on study duties passed in the previous academic year. These conditions will not exceed the range of above specified general duties. These students are required to contact the teacher of the relevant study group at the beginning of the semester.

 

Note:

Pathological physiology I is followed by pathological physiology II completed with a credit and exam and the content of which also covers the knowledge from the pathological physiology I course in its entirety.

Literature -
Last update: doc. MUDr. Jan Cendelín, Ph.D. (26.09.2023)

Mandatory literature:

Sobotka et al.: Pathophysiology – Laboratory Exercises. 2013, Karolinum, 2013

McPhee, Hammer et al.: Pathophysiology of Disease: An Introduction to Clinical Medicine. The McGraw-Hill Companies, Inc., 6th Edition 2010 (or later issues)

Educational materials of the Department of Pathophysiology published on educational portals of the Faculty of Medicine in Pilsen, Charles University or the webpage of the department or provided to students in printed or electronic form.

 

Recommended literature:

Hueher et al.: Understanding Pathophysiology. Elsevier, 2017

McCance and Huether: Pathophysiology, the Biologic Basis for Disease in Adults and Children. Elsevier, 2019

Banasik and Copstead: Pathophysiology. Elsevier, 2019

Hulín et al.: Pathophysiology. Slovak Academic Press, 1997 (or later issues)

Silbernagl and Lang: Color Atlas of Pathophysiology. 3rd edition, Georg Thieme Verlag KG, 2016

Price and Wilson et al.: Pathophysiology – Clinical concepts of disease processes. Mosby, Inc., 2003

Guyton: Human physiology and mechanisms of disease. W. B. Saunders Company, the latest issue

Requirements to the exam -
Last update: doc. MUDr. Jan Cendelín, Ph.D. (26.01.2024)

Pathological physiology I is followed by pathological physiology II that is completed with a credit and an exam.

 

Conditions for the pathological physiology II exam:

The condition for registration for the exam is to obtain a credit in pathological physiology I and pathological physiology II, if not set differently for a specific term.

The student is obliged to register for the exam before the deadline using SIS (other ways of registration will not be accepted). Registration is necessary for the regular term as well as for potential 1st re-examination or 2nd re-examination.

 

The required knowledge contains curriculum of both subjects pathological physiology I and pathological physiology II. Knowledge of other subjects to which pathological physiology follows is also necessary (see syllabus).

 

The exam consists of a practical exam and oral exam. The required knowledge is based on the list of exam questions and the syllabus of the subjects pathological physiology I and pathological physiology II (for detailed syllabus and list of questions for the practical exam and oral exam see webpage of the Department of Pathophysiology:

http://patofyziologie.lfp.cuni.cz/?lang=en

 

Practical exam consists of 1 question and ECG record analysis. Failure in the practical exam means classification of the exam “fail”.

 

Oral exam consists of 4 questions. To pass the oral exam, the student must show sufficient knowledge in each of these 4 questions.

 

Final classification takes into consideration not only the performance in the oral exam but also the classification of the practical exam.

 

Practical and oral exams constitute one complex and cannot be separated into two examination terms. In the case of classification of any part of the exam "failed", the student is subjected to both the practical and oral exam again in the 1st or 2nd reexamination.

 

Due to capacity reasons, the exam can be divided into several days within the given exam date. Students are required to attend the appropriate stage of the exam according to the schedule or examiner's instructions.

See also goals of teaching:

http://patofyziologie.lfp.cuni.cz/?page_id=1941&lang=en

Syllabus -
Last update: doc. MUDr. Jan Cendelín, Ph.D. (26.09.2023)

Pathological physiology I: Syllabus of the subject - General medicine

Individual topics can be moved between the subjects pathological physiology I and pathological physiology II.

 

General pathophysiology I

Introduction to the subject, basic terms, disease and its course

Etiological factors

Classification of etiological and risk factors, particular intrinsic and extrinsic etiological factors

Pathophysiology of wound healing

Developmental disorders

Causes and mechanisms of developmental disorders, diseases linked to a certain age

Gametopathy, blastopathy, embryopathy, fetopathy, perinatal damage

Growth disorders

Aging, terminal states, death of an individual, cell death

Pathophysiology of immunity

Immunodeficiency, allergy, autoimmune diseases, inflammation, transplantation

Pathophysiology of thermoregulation, fever

Pathophysiology of tumors

Special pathophysiology I

Pathophysiology of the lymphatic system

Pathophysiology of the blood

Changes of blood volume and composition

Disorders of erythrocytes, anemia, polycythemia, polyglobulia, hemolysis

Pathophysiology of leukocytes – changes of number, disorders of function, leukemias

Bleeding, hemorrhagic diathesis, thrombotic states

Pathophysiology of the cardiovascular system

Inborn and acquired heart defects

Disturbances of peripheral blood circulation, atherosclerosis, endothelial dysfunction

Ischemic heart disease, arrhythmias, arterial hypertension, thromboembolic disease

Cardiac insufficiency and failure, circulatory shock

Heart hypertrophy and dilatation, cardiomyopathy, heart inflammations

Multiorgan dysfunction and multiorgan failure

Pathophysiology of the endocrine system

General causes of diseases of the endocrine glands, mechanisms of endocrine disorders

Pathophysiology of individual endocrine structures and hormones

Pathophysiology of the reproductive system

Pathophysiology of the bones

Pathophysiology of the muscles

Manifestations of diseases of the skeletal muscles and their innervation

Myopathies, muscular dystrophias, myositis, rhabdomyolysis, crush syndrome, compartment syndrome, malignant hyperthermia

Acid-base balance and its disorders

Pathophysiology of body fluids

Pathophysiology of mineral metabolism

Pathophysiology of the gastrointestinal tract

Pathophysiology of the oral cavity, esophagus, stomach, gut, exocrine pancreas

Dysphagia, nausea, vomiting, dyspepsia, constipation, diarrhea, gastrointestinal tract bleeding

Practical knowledge and skills I

Principles of science, statistics, injection technique, anesthesia, pathophysiological aspects of wound treatment, use of electricity in medicine, electrocardiography, blood pressure measurement, examination of hemorrhagic diatheses

 

Detailed syllabus for pathological physiolopgy I and subsequent subject pathological physiology II:

http://patofyziologie.lfp.cuni.cz/

Course completion requirements -
Last update: doc. MUDr. Jan Cendelín, Ph.D. (08.02.2024)

Conditions for the credit – pathological physiology I:

 

1. Active attending practical exercises – 2 absences per semester are allowed.

For the practical exercises, the student must be theoretically prepared for the topic of the given class and is obliged to acquaint himself with the guideline for the given experiment or task (see study literature). Prerequisites are knowledge from the fields to which the subject pathological physiology I follows, i.e. anatomy, histology, embryology, biology, genetics, chemistry and biochemistry, biophysics, physiology and microbiology. Students, who did not attend the class in time, will be not admitted to the class.

 

2. Submitting of correctly elaborated protocols of all experiments and practical exercises to the teacher, who assesses their correctness and confirms them as fulfilled, or returns them for revision.

 

The conditions of the credits for students having an individual study plan, who enrolled pathological physiology II for the second time, will be appointed individually in dependence on study duties passed in the previous academic year. These conditions will not exceed the range of above specified general duties. These students are required to contact the teacher of the relevant study group at the beginning of the semester.

 

Note:

Pathological physiology I is followed by pathological physiology II completed with a credit and exam and the content of which also covers the knowledge from the pathological physiology I course in its entirety.

 
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