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Course, academic year 2014/2015
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General Pharmacology - CVSE3P0012
Title: Obecná farmakologie
Guaranteed by: Department of Pharmacology 3FM CU (12-FARM)
Faculty: Third Faculty of Medicine
Actual: from 2014 to 2014
Semester: winter
Points: 4
E-Credits: 4
Examination process: winter s.:
Hours per week, examination: winter s.:30/30, C+Ex [HS]
Extent per academic year: 60 [hours]
Capacity: unknown / unknown (unknown)
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
Key competences:  
State of the course: taught
Language: Czech, English
Teaching methods: full-time
Teaching methods: full-time
Level:  
Guarantor: prof. MUDr. Miloslav Kršiak, DrSc.
prof. MUDr. Jan Bultas, CSc.
Examination dates   Schedule   
Annotation -
Last update: doc. MUDr. Jiří Slíva, Ph.D. (23.09.2020)
In the subject of General pharmacology (in winter semester of the 3rd section of study) there are taught essentials of pharmacodynamics (e.g. interactions of drugs with receptors, molecular targets for drug action), fundamentals of pharmacokinetics (e.g. the half-life and its uses), drug interactions, introduction to clinical trials of drugs, adverse drug reactions, etc. Students are also taught pharmacology of autonomous system, pharmacology of most important neurotransmitter systems, pharmacology of enzymes and of transport proteins and a prescription writing.
Aim of the course -
Last update: doc. MUDr. Jiří Slíva, Ph.D. (23.09.2020)

The aim of the subject is to learn students to understand general pharmacological principles. This understanding is important for the study of specific classes of drugs (scheduled later in courses of the 3rd, 4th and 5th section and of the Master’s study of General Medicine). Physicians should understand how and why drugs act in order to use them rationally in therapy. An additional aim is to learn students to prescribe a drug.
Literature -
Last update: doc. MUDr. Jiří Slíva, Ph.D. (23.09.2020)

1. Recommended textbook:

Pharmacology - H. P. Rang, et al. - 9th ed. - Elsevier Churchill Livingstone, 2019 (or  8th ed.)

or (alternatively)

Basic & clinical pharmacology - B. G. Katzung - 14th ed. - Lange Medi. Books - McGraw-Hill 2018 (or 13th ed. )

 

2. Additional texts convenient for a suplementary reading:

Pharmacology (Lippincott's Illustrated Reviews). 6th ed. Wolters Kluver/Lippincott , 2015 (or  5th ed.)

Principles of Pharmacology (The Pathophysiological Basis of Drug Therapy) Golan D.E. et al. , Wolters Kluver/Lippincott , 2012

Pharmacology An Illustrated Review  Simmons M.A., Thieme, 2012

Medical Pharmacology at a Glance - M. J. Neal. 8th ed. Wiley-Blackwell, 2015 (or 7th ed.)

British National Formulary No.70[or higher] - BMJ Books, September 2015 [or more recent editions].
Teaching methods -
Last update: doc. MUDr. Jiří Slíva, Ph.D. (23.09.2020)

Methods of teaching

Teaching is in the form of lectures and practicals. The  topic of lecture is mostly discussed in the immediately following practical   by a form of quiz. Therefore, students should be coming to practicals with basic knowledge on the scheduled topic acquired in the lecture, its  study materials (e.g. *.ppt ducuments on http://vyuka.lf3.cuni.cz/) and from recommended literature. The pharmacology room is equipped with computer stations for students and with a software enabling computer simulation of drug effects, and pharmacokinetics.
Requirements to the exam -
Last update: doc. MUDr. Jiří Slíva, Ph.D. (23.09.2020)

Requirements for examination (2019-2020)

 

A condition for a successful passing the subject "General Pharmacology" is to meet criteria of a Final test from general pharmacology.

A prerequisite for writing the final test is obtaining a credit from general pharmacology. The credit is obtained after at least 80% attendance of practicals and meeting criteria of four interim tests (Tests for credits) during the course of General pharmacology:

1st TEST for credit - PHARMACODYNAMICS I  (Pharmacology of autonomic nervous system - Teaching Unit (TU) 5-8) - 5th week of the semester

2nd TEST for credit - PHARMACOKINETICS (Basic principles, biotransformation and elimination of DRUGS, TU drugs TU 1-4, 10)  - 7th week of the semester

3rd  TEST for credit - PHARMACODYNAMICS II (Pharmacology of selected receptors, ion channels, enzymes and regulatory systems - TU 9, 11-16, 18)- 10th week of the semester

4th TEST for credit - DRUG PRESCRIPTION (TU 24) - 13th week of the semester

 

 The tests for credits will be multiple-choice, will be written during practicals in semester weeks given above.

 

Examination

Examination will be in a form of final multiple-choice test

 

Terms of exam (Final tests):

                           Jan 30, 2020 - 10:00-11:30

                           Feb 6, 2020 - 10:00-11:30

                           Feb 13, 2020 - 10:00-11:30

 

Capacity: 75 students per term, Final tests will be written in the Syllaba lecture halls (30/01 and 13/02) and Jonáš lecture hall (06/02)

 

Other exam terms are: 20/02, 14/5, 11/6 and 10/9/2020 (the place will be specified in advance).

 

The questions of the final test will be mainly based on topics in seminars and lectures (!!!):

 

Basic terminology in pharmacology

Principles of pharmacokinetics

Autonomic pharmacology - sympathetic system.

Autonomic pharmacology - parasympathetic system.

Biotransformation and elimination of drugs, drug interactions.

Drugs acting via dopamine, serotonin, histamine

Drugs acting by inhibition of enzymes

Drugs acting via ion channels and transporters

Principles of pharmacologic blood pressure control

Drug and remedy addiction

Biological therapy, gene therapy, pharmacogenetics

Drug discovery and development. Preclinical and clinical trials. EBM.  Placebo.

Adverse drug reactions. Regulatory agencies (EMA etc). Pharmacovigilance. Pharmacoeconomics.

Complementary and Alternative Medicine (CAM), homeopathy

Principles of toxikology - intoxications, termination of drug effect.

 

In case of failure in the final test, a student will have a possibility of another test (2nd test). In case of failure in the 2nd test, a 3rd test will be possible as the last chance. 

 

 

 
Syllabus -
Last update: doc. MUDr. Jiří Slíva, Ph.D. (23.09.2020)

General Pharmacology 2019/2020

 

week

Teach.Unit No.

LECTURES

Teach.Unit No.

PRACTICALS

1

30/9-4/10

1

TH

Introduction to pharmacology. Principles of pharmacokinetics

J. Slíva

2

Basics of drug prescription. Introduction to pharmacology.

Basic terminology.Organization of teaching and  testing.

J. Slíva, M. Lapka

2

7/10-12/10

3

TH

Biotransformation and elimination of drugs, drug interactions.

J. Slíva

 

4

QUIZ -  Basics  of pharmacokinetics

Pharmacokinetics, single and repeated dose administration, changes

 in disease states  ‒ computer simulations

P. Potměšil

3

14/10-19/10

 

5

TH

Autonomic pharmacology –  sympathetic system.

M. Šustková

6

QUIZ - Autonomic pharmacology – sympathetic system

Alfa/beta agonists , antagonists , catecholamines.

Case study, drug prescription.

P. Potměšil

4

21/10-26/10

7

TH

Autonomic pharmacology – parasympathetic system.

J. Slíva

 

8

QUIZ - Autonomic pharmacology – parasympathetic system.

M agonists,  antagonists,  Nicot.  agonists, antagonists,  spasmolytics,

prokinetics, antiglaucomatics, peripheral muscle relaxants.

 Case study, drug prescription     

M. Šustková

5

28/10-2/11

9

TH

Drugs acting via dopamine, serotonin,

histamine

M. Šustková

 

10

1st TEST for credit – PHARMACODYNAMICS I  (Pharmacology of autonomic nervous system) – TU 5, 6, 7, 8)

QUIZ - Biotransformation and elimination of drugs, drug interactions.

Types of pharmacokinetic drug  interactions (level of biotransformation and elimination)

use of MICROMEDEX, AISLP

 P. Potměšil

6

4/11-9/11

11

TH

Drugs acting by inhibition of enzymes

J. Slíva

 

12

QUIZ - Drugs acting via dopamine, serotonin,

histamine

Important drugs acting via dopamine, serotonin, histamine - antipsychotics, antiparkinsonics,

antimigrenics, antiemetics, antihistaminics, H2-antagonists etc.  

Case study, drug prescription

M. Šustková

7

11/11-16/11

13

TH

Drugs acting via ion channels and

transporters

 P. Potměšil

 

14

2nd TEST for credit – PHARMACOKINETICS (basic principles, biotransformation and elimination of DRUGS, tu drugs TU 1, 3, 4, 10)

 QUIZ -Drugs acting by inhibition of enzymes

Cholinesterase inhibitors , inhibitors of ACE, cyklooxygenase, HMG-CoA reductase, PDE, etc.

Case study, drug prescription    M. Lapka, K. Němeček

8

18/11-23/11

15

TH

Pharmacological options of affecting the essentials regulatory systems  - an example of control of blood pressure and systemic circulation

Ch. Charalambous

 

16

QUIZ -  Drugs acting via ion channels and

transporters

QUIZ - Pharmacological options of affecting the essentials regulatory systems  - an example of control of blood pressure and systemic circulation

Examples of drugs acting on  ion channels – calcium  channel

blockers, local anaesthetics, IPP, antidepressants, etc.

Case study, drug prescription

Treatment of hypertension - case studies, drug prescription

P. Potměšil

9

25/11-30/11

17

TH

Drug and remedy addiction

M. Šustková

 

18

Phytotherapy

M. Šustková

10

2/12-7/12

19

TH

Biological therapy, gene therapy

J. Slíva

 

20

3rd TEST for credit PHARMACODYNAMICS II ( pharmacology of selected receptors, ion channels, enzymes and regulatory systems – TU 9, 11-16, 18)

QUIZ -   Basic terms in drug and remedy addiction

Alcohol, tobacco and drugs

M. Šustková

 

11

9/12-14/12

21

TH

Adverse drug reactions. Regulatory agencies (EMA). Pharmacovigilance

Pharmacoeconomics.

K. Němeček

 

22

Pharmacovigilance in common praxis

 

M. Pohl

12

16/12-21/12

 

23

TH

Drug discovery and development. Evidence of drug efficacy. EBM.  Placebo.

 K. Němeček

 

24

QUIZ - Drug discovery and development. Evidence of drug efficacy . EBM.  Placebo.

Evidence of drug efficacy – from marketing tricks to Cochrane database + prescription (AISLP, Micromedex,…)

J. Slíva

 

13

6/1-11/1

 

25

TH

Complementary and Alternative Medicine (CAM), homeopathy

P. Potměšil

 

26

4th TEST for credit – DRUG PRESCRIPTION

 

J. Slíva

14

13/1-18/1

27

TH

Principles of toxicology – intoxications, termination of drug effect.

P. Potměšil

 

28

Abused drugs in sport. Doping.

 

J. Slíva

15

20/1-25/1

29

TH

Overview  of molecular mechanisms of drug effects

  M. Šustková

 

30

QUIZ -  Principles of toxicology – intoxications, termination of drug effect.

Credits

M. Šustková
Entry requirements -
Last update: doc. MUDr. Jiří Slíva, Ph.D. (23.09.2020)

Requirements for the study of the subject

A successful completion of parts of 1st and 2nd section of the curriculum, particularly those of Cellular basis of medicine and Structure and functions of human body.
 
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