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Course, academic year 2023/2024
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Medical Biophysics and Informatics - CVSE1P0002
Title: Lékařská biofyzika a informatika
Guaranteed by: Department of Medical Biophysics and Informatics 3FM CU (12-ULBI)
Faculty: Third Faculty of Medicine
Actual: from 2012
Semester: winter
Points: 3
E-Credits: 3
Examination process: winter s.:
Hours per week, examination: winter s.:14/34, C+Ex [HS]
Extent per academic year: 48 [hours]
Capacity: unknown / unknown (unknown)
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
Key competences:  
State of the course: taught
Language: Czech, English
Teaching methods: full-time
Teaching methods: full-time
Level:  
Guarantor: prof. MUDr. Jozef Rosina, Ph.D., MBA
Examination dates   Schedule   
Annotation
Last update: doc. Ing. Jana Vránová, CSc. (17.02.2012)
The course of medical biophysics is aimed at physiological and pathological phenomena and processes in human medicine and physical principles of diagnostics and therapy in medicine. Mechanisms of physical factors influencing man health are discussed.
Aim of the course
Last update: doc. Ing. Jana Vránová, CSc. (17.02.2012)

Primary aim of the course is to introduce physical background of processes and phenomena in medicine. Students will be informed about elementary terms of medical biophysics having direct association with medical diagnostics and therapy, physical principles of structure of matter, transport at the cell membrane, and bioenergetics of organisms. Course will introduce also subjects of biomechanics and kinesiology, electrical manifestations of organism and effect of electricity of organism, optics, acoustics and radioactivity. Physical background of medical imaging methods will be presented, too.

As the benefit from the course students will be able to address biophysical problems having close relationship to health and sickness in man. In particular: physical fundamentals of physiological and pathological processes and related principles of diagnostics and therapy. Modern medicine takes advantage of technically complicated devices for diagnostics, preventive medicine and treatment, which cannot be fully employed without knowledge about physical principles of their function. Understanding of medical devices' principles is also one of course benefits.

Literature
Last update: doc. Ing. Jana Vránová, CSc. (17.02.2012)

Giancoli D.C. - Physics for Scientists and Engineers with Modern Physics, Prentice-Hall Inc., 2006

Teaching methods
Last update: doc. Ing. Jana Vránová, CSc. (17.02.2012)

Lectures, practical exercises

Requirements to the exam
Last update: doc. Ing. Daniel Šuta, Ph.D. (04.02.2022)

Fro credits the students are expected to attend all seminars from Informatics and biophysical practices. For written / oral exam are students expected to fulfill credit conditions and to be familiar with the content of biophysical lectures and recommended literature (see above).

Students who are not enrolled in the course repeatedly will take the exam in the regular term in the form of a written test (i.e. the test can be taken only once, the dates of the test are published in the SIS and the student registers himself/herself for the selected term in the SIS.).

The other terms will be by oral examination and the dates of the oral examination are published in the SIS and the student registers himself/herself for the selected term in the SIS. 

Topics for the examination:
1. Colligative properties of solutions
2. Phase diagram for solvent and solution
3. Raoult's law
4. Osmotic pressure – definition, physiology
5. Freezing point change by concentration
6. Boiling point change by concentration
7. Cohesion, Cohesive attraction
8. Cell membrane – function, structure
9. Transport across the membrane
10. Membrane potential
11. Action potential
12. Mechanical waves – definition, types
13. Sound and its attributes
14. Human ear – description and function
15. Tone audiometry
16. Electromagnetic waves and spectrum
17. Refracted, Critical, Reflected ray
18. Reflection, Refraction, Lenses
19. Human eye – structure and optics
20. Photoreceptor cells in the retina
21. Myopia
22. Hyperopia
23. Astigmatism
24. Glaucoma, cataract
25. Light microscopy
26. Electron microscopy
27. Laser
28. X-ray and CT in diagnostics
29. PET
30. Gamma camera and SPECT
31. Ionizing radiation in therapy
32. Radiosensitivity and fractionation
33. Ionizing radiation in diagnostics
34. Ultrasonography
35. ECG
36. EEG
37. MRI
38. Infrared imaging
39. Radioactivity – description, types
40. Gray, Sievert, Becquerel
41. Half-life in radioactivity
42. Gamma radiation – definition, penetration, hazard
43. X-rays – definition, penetration, hazard
44. X-ray production
45. Photoelectric effect
46. Doppler effect
47. Positron Annihilation
48. Pair Production
49. Stochastic and Non-stochastic effect of radiation
50. Somatic, Genetic and Teratogenic effects of radiation
51. Ionizing radiation, ionization – def., quantities
52. AC, DC – injury, severity, thresholds
53. „Let-go current“ for AC and DC
54. Why is AC more danger than DC?
55. Electric current injury: symptoms + signs
56. Effects of electric current in human body
57. Gamma knife
58. Light and its attributes
59. Compton scatering
60. Excitation and luminescence

Syllabus
Last update: doc. Ing. Jana Vránová, CSc. (17.02.2012)

Structure of matter - elementary types of forces in nature, atom - its structure and characteristics, elementary particles, atomic nucleus and atomic shell

Bioenergetics - heat, temperature and its measurement, control of body temperature, utilization of cold and hot in medicine

Biomechanics and kinesiology - biomechanics of tissue, biomechanics of blood circulation, respiration, effect of mechanical forces on organism, therapeutic effect of mechanical energy

Electric current - electric properties of tissue and organs, electric current conduction in tissue, action potential - bioelectric manifestation and use in diagnostics, electric current in diagnostics and therapy, electric current injury

Optical and thermal radiation - radiation properties, optical radiation sources and detectors, optical methods and measurement, visible light, theory of color vision, adaptation to light and dark, eye and eye defects, ultraviolet and infrared radiation, medical use of thermal energy, biophysics of thermoregulation

Acoustics - basic terms, physiological acoustics, outer middle and inner ear, audiometry, noise effects to organism, infrasound, ultrasound, generation and biological effects of ultrasound, diagnostic use of ultrasound, therapeutic use of ultrasound

Radioactivity - natural and artificial radioactivity, characteristics of ionizing radiation, types of radioactive reactions, interaction of ionizing radiation with matter, biological effects of ionizing radiation, protection against ionizing radiation, detection of ionizing radiation, use of ionizing radiation in diagnostics and therapy, Chernobyl and atomic power plants, irradiation sickness, nuclear power supplies, nuclear weapons

Ecological biophysics - effects of atmospheric pressure on human body, effects of decreased and increased atmospheric pressure, biometeorology, effects of mechanical energy on human body, Biological aspects of aerospace traffic, biological aspects of space crafts, overload and a weightlessness, magnetic field, cell phones, effects of coldness on human body

Introduction to nuclear medicine - definition of discipline, radio-pharmaceutics, radio-nuclide in diagnostics, detection techniques in nuclear medicine, principle of scintillation detector, devices for personal and protective dosimetry, use of gamma-camera, PET, SPECT.

Introduction to radiology - principle of X-ray tube, bremsstrahlung and characteristic radiation, detection of X-ray radiation, contrast materials, CT, NMR.

Physical properties of new materials - materials s with recovery, use of collagen-based materials in substitution therapy

Detail description of all lectures and practical exercise are found on the website: http://vyuka.lf3.cuni.cz

 
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