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IA - Biochemistry II. - CSFBX42CL
Title: IA - Biochemie II.
Guaranteed by: Department of Biochemistry, Cell and Molecular Biology 3FM CU (12-BIOC)
Faculty: Third Faculty of Medicine
Actual: from 2016
Semester: summer
Points: 1
E-Credits: 1
Examination process: summer s.:
Hours per week, examination: summer s.:10/9, other [HT]
Capacity: unknown / unknown (unknown)
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
Key competences:  
State of the course: not taught
Language: Czech
Teaching methods: full-time
Teaching methods: full-time
Level:  
Additional information: http://www.lf3.cuni.cz/chemie/
Guarantor: prof. RNDr. Eva Samcová, CSc.
Mgr. Vladimíra Kvasnicová
Classification: Medicine > Basic Sciences
Attributes: Modul IA
Examination dates   Schedule   
Annotation -
Last update: Mgr. Vladimíra Kvasnicová (03.10.2010)
Biochemistry II is taught in the winter and summer semesters of the second year as a part of Module IA. It builds on Biochemistry I, part of the same module, which is taught in the summer semester of the first year. Biochemistry II deals with functional biochemistry in four major areas: 1) Cardiovascular system and 2) Endocrine system (winter semester), 3) Nervous system I, motor control and 4) Nervous system II, sensory organs (summer semester). This course is integrated with parallel courses of physiology, histology and anatomy of the same systems.
Aim of the course -
Last update: Mgr. Vladimíra Kvasnicová (03.10.2010)

This course aims to provide students with an understanding of the biochemistry of the cardiovascular, endocrine and nervous systems.
Literature -
Last update: Mgr. Vladimíra Kvasnicová (03.10.2010)
  • Murray, Robert K.: Harper´s biochemistry, 24th ed. (or the other),1996, ISBN 0838563115
  • Pamela C. Champe, Richard A. Harvey: Lippincott´s Illustrated Reviews - Biochemistry, ISBN 0-397-51091-8
  • Jan Koolman, Klaus-Heinrich Röhm: Color Atlas of Biochemistry, Thieme, Stuttgard, 1996, ISBN 3-13-100371-5
  • J.G.Salway: Metabolism at a Glance, 2nd ed., Blackwell Science Ltd, 1999, ISBN 0-632-05274-0
  • Thomas M. Devlin et al.: Textbook of Biochemistry With Clinical Correlations, 4th ed., ISBN 0-471-15451-2
Teaching methods -
Last update: Mgr. Vladimíra Kvasnicová (03.10.2010)

winter semester:
lectures (4 x 2 hours), seminars (3 x 3 hours), integrated conferences (2 x 5 hours), altogether 27 hours.

summer semester:
lectures (4 x 2 hours), seminars (3 x 3 hours), integrated conferences (2 x 5 hours), altogether 27 hours

Altogether: 54 hours / second year
Requirements to the exam -
Last update: Mgr. Vladimíra Kvasnicová (26.09.2011)

This course ends with sub-credits (colloquia) in both the winter and summer semesters, which are required to receive credit for the whole Module IA (in both semesters). Modulu IA exam takes place at the end of the second semester.

REQUIREMENTS FOR SUB-CREDIT

  • winter semester: exam from biochemistry of hormones taught in the 3rd semester including relevant knowledge from the first year, dates will be announced by each group´s teacher - examined in the exam period
  • summer semester: exam from all of biochemistry - from both first and second years, see below for a list of required topics; dates will be organised by each group´s teacher during the summer semester - examination usually starts from the last week in March

Every student can be examined three times at the most and students must attend scheduled exams.

SIGNING SUB-CREDITS INTO CREDIT BOOK (INDEX)
Dates for signing Module IA subcredit for the Biochemistry II course in the Index will be posted on the chemistry notice board on level 4. The following teachers are responsible for signing the Index for the following groups:

  • Pavla Balínová (409): groups 1 and 2
  • Josef Fontana (410): groups 3 and 4

REQUIREMENTS FOR SUB-CREDIT EXAMINATION IN THE SUMMER SEMESTER

  • Bioenergetics (macroergic compounds, citric acid cycle, respiratory chain, formation of ATP)
  • Enzymes (classification, structure, coenzymes, cofactors, zymogens, isoenzymes, examples of enzymes, regulation of enzyme activity)
  • Vitamins (classification, importance in metabolism, relationship to coenzymes)
  • Saccharides (classification, structure, digestion and resorption, fibre, functions in organism, maintenance of glycemia)
  • Metabolism of saccharides (glycolysis, pentose-phosphate cycle, gluconeogenesis, metabolism of glycogen, regulation of the saccharide metabolism on the cell level)
  • Lipids (classification, structure, digestion and resorption, importance: fatty acids, triacylglycerols, phospholipids, glycolipids, cholesterol and steroids)
  • Metabolism of lipids (transport in plasma - lipoproteins, ?-oxidation, ketogenesis, fatty acids synthesis, synthesis of cholesterol, bile acids)
  • Amino acids and proteins (classification, structure, digestion and resorption, function and general properties of amino acids and proteins in organism, ornithine a citrulline, origin of plasmatic proteins)
  • Metabolism of amino acids (AAs) and proteins (proteases, synthesis of nonessential AAs, degradation of all proteinogenic AAs: transamination, deamination, decarboxylation, bioegenic amines - monoamines; glucogenic and ketogenic AAs, metabolism of ammonia, urea cycle)
  • Biochemistry of muscle cell (energy sources, muscle contraction, myoglobin)
  • Biosynthesis and degradation of heme (cellular and body localization, regulation, porphyrins, hemoproteins, bilirubin - transport, metabolism, excretion)
  • Biochemistry of erythrocyte (energy metabolism, transport of blood gases, antioxidative systems, hemoglobin - structure and function, derivatives)
  • Oxidative stress (formation of reactive oxygen and nitrogen species - their importance and properties, antioxidative systems)
  • Respiration (transport of O2 and CO2 in blood, forms of CO2, function of O2 in a cell, saturation curve of hemoglobin, factors effecting the affinity of hemoglobin to oxygen)
  • Internal environment and acid-base balance /ABB/ (maintaining stable pH, ionic composition of extra- and intracellular fluid, buffers, role of the kidney and the lungs in maintaining ABB, ABB disorders)
  • Composition of blood plasma (low- and high molecular mass compounds - their origin, importance and fate; osmotic pressure)
  • Proteins of blood plasma (classification, function, difference between serum and plasma, electrophoresis, oncotic pressure)
  • Immunoglobulins (classification, structure, properties, origin, function)
  • Hormones in a metabolism (regulation of biochemical processes, exceptional situations)
  • Eicosanoids, nitric oxide (structure, synthesis, function)
  • Biochemistry of the kidney (formation and composition of urine, excretion and resorption of ions and water - regulation)
  • Biochemistry of conective tissues (collagen and elastin - structure, importance of vit. C; proteoglycans, glycoproteins)
  • Metabolism of xenobiotics (basic reactions, mixed function oxidases, metabolism of ethanol)
  • Starve-feed cycle (biochemical changes after feeding, during fasting and starvation)
  • Energy metabolism of CNS, composition of liquor
  • Neurotransmitters (classification, synthesis, degradation)
  • Metabolism of iron (absorption, transport, storage, importance)
Syllabus -
Last update: Mgr. Vladimíra Kvasnicová (03.10.2010)
  • winter semester

LECTURES
1) Biochemistry of the heart and blood vessels
Conference: circulatory system
2) Metabolism of hormones (synthesis and degradation)
3) Endocrine function of pancreas and GIT
4) Skin, bone, adipose tissue
Conference: immunity and endocrine system

SEMINARS
1) Hormones in metabolism
2) Exceptional situations - biochemical point of view
3) Metabolism during pregnancy. Newborns.

  • summer semester

LECTURES
1) Energy metabolism of CNS, cerebrospinal fluid
2) Synthesis and degradation of neurotransmitters
3) Influence of chemical substances on human behaviour
Conference: nervous system I, regulation of motor functions
4) Biochemistry of sensory perception
Conference: nervous system II, sensory organs

SEMINARS
1) Biochemistry in the medicine
2) Guide to the Module A examination I
3) Guide to the Module A examination II
Entry requirements -
Last update: Mgr. Vladimíra Kvasnicová (03.10.2010)

Course IA - Biochemistry II builds on courses Medical chemistry and biochemistry in Module IB and Biochemistry I in Module IA.
 
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