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Last update: MUDr. Andrea Pavlíková (25.09.2013)
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Last update: MUDr. Andrea Pavlíková (25.09.2013)
The goal of this object is to take up students with Selected Chapters of Medical Biochemistry and subsequently also with Introduction to the Clinical Chemistry to the extent of requirement of open cover nurse. |
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Last update: MUDr. Andrea Pavlíková (25.09.2013)
? Karlson P: Základy biochemie, Praha, Nakladatekství ČSAV Praha 1965, Academia 1981 resp. kterékoliv vydání
? Musil a kol., Lékařská chemie a biochemie,Avicenum, Osveta, 1991 resp. další vydání
? Voet, D.a J.: Biochemie, Viktoria Publishing, Praha 1995
? MURRAY, R. K., GRANNER, D. K., MAYES, P.A., RODWELL, V. W. Harperova biochemie. Nakladatelství a vydavatelství H&H ,1998..
? Racek J.: Klinická biochemie, Galén 1999., 2006
? J. Masopust: Klinická biochemie požadování a hodnocení biochemických vyšetření I. a II., Univerzita Karlova, Karolinum, Praha 1998
? Zima T.: Laboratorní diagnostika, Galén 2002
? Vodrážka Z.: Biochemie. 2. vyd., Academia Praha, 1996
? Kolektiv autorů, uspořádal Musil: Lékařská chemie a biochemie. Avicenum/Osveta, 1990
? Průša, R. a kol.: Multimediální učebnice DNA diagnostiky na CD-ROM. 2. LF KU, Praha 1998 (www.lf2.cuni.cz./projekty/prusa-DNA)
? Sacher R.A., McPherson R.A.: Widmann´s clinical interpretation of laboratory tests. USA 2000
? Devlin T.M.: Textbook of Biochemistry with Clinical Correlations, Philadelphia, Pennsylvania, 2006
? Thomas Lothar : Clinical Laboratory Diagnostics ? Use and Assesment of Clinical Laboratory Results, Frankfurt 1998
Další materiály pro výuku
? www.cia.cz
? www.cskb.cz
? www.geocities.com/kocna_2000/kblink.htm
? www.lf1.cuni.cz
? www.lf3.cuni.cz/chemie/
? www.maxdorf.cz
? www.medicina.cz
? www.naskl.cz
? www.nlk.cz/nlkcz/infozdroj/detail.php?odvetvi_id2=11&odvetvi2=BIOCHEMIE
? www.sekk.cz
? www.westgard.com
? www.zdravcentra.cz
? www.sportgym.cz/_pages/_aktivity/sipvz/vyukove_prezentace/dna.ppt |
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Last update: MUDr. Andrea Pavlíková (25.09.2013)
Lectures |
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Last update: MUDr. Andrea Pavlíková (25.09.2013)
1. Year; winter semester : 5 x 2 lecture hours
1. Introduction to Biochemistry, proteins: amino acids, peptides, proteins (characteristics, structure, properties and function), principles of turnover nitrogen containing matters, amino acids, proteins (decarboxylation, deamination, transamination, urea origin) Enzymes: characteristics, classification, structure, properties and function, coenzymes Metabolism of saccharides: classification, properties, from medical point of view important representative, principles of turnover of saccharides ? glycolysis, gluconeogenesis, origin and degradation of glycogen, amino sugars, uric acids Metabolism of lipids, biologically important sterols: classification, properties, from medical point of view important representative, principles of turnover of lipids, degradation and synthesi of fatty acids, turnover of lipids and phospholipids 3. Nucleic acids: DNA, RNA (mRNA, tRNA, rRNA), structure, constitution, significance, function, genetic code, trans-scription,n translation, protein synthesis, post-translation modifications, principles of molecular genetics Cell structure: composition and function of cell membrane, transport across the membrane, Na+-K+ ? ATPase, cell organelles and their importance 4. Biologic oxidation: energy transformation, high energy compounds, ATP a his significance for organism Intermediary metabolism: endergonic, exergonic and amphibolic processes, citric cycle, respiratory chain, significance of acetyl-CoA and intermediate products of citric cycle, origin and turnover of keton bodies Regulation of biochemical processes at the level of organism and cell level: cell compartments, receptors, significance and function of cAMP, cGMP, fosfatidylinositol´s, hormones, back feed regulation, examples 5. Hormones and their function: classification, function, examples Introduction to the Clinical Chemistry: definition of clinical chemistry, pre-analytical, analytical, post analytical phase
1. Year; summer semester: 5 x 2 lecture hours
1. Biochemical function of blood, respiration and kidneys: blood composition ? plasmatic proteins, biochemistry of respiration (structure and function of haemoglobin and myoglobin, examination of blood ? plasma, serum, biochemical aspects of kidney function, urine origin, examination of urine (pre-analytical phase) 2. Biochemical function of gastro-intestinal tract, liver and pancreas: biochemistry of indigestion and absorption, nutrition-significance for organism, vitamins, origin and significance of bile, biochemical examination of GIT 3. Biochemical significance of examination of body fluids and minerals Internal environment and Acid Base Balance (ABB): composition, changes, kidney?s participation on keeping stable internal environment, ABB examination (pre-analytical phase) 4. Biochemistry of extracellular matrix, muscle, nervous cell: structure of extracellular matrix (collagen, elastin, proteoglycans) specialized extracellular matrix ? cartilage, bone, significance, function, structure of muscle cell, biochemical base of muscle contraction and relaxation, nervous regulation of muscle activity, structure of nervous cell, synapses, principle of transfer of nervous excitement Principles of medical immunology: antigen, antibody, immune reaction, principle of immune-chemical examination methods 5. Molecular principle of tumour illnesses: growth, tumour growth, tumour markers Disturbances of metabolism of saccharides, lipids, AMA
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