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IIC - 19. Disorder of Immunity (Immunology) - CMCP1934

Title:	IIC - 19. Poruchy imunity (imunologie)
Guaranteed by:	Department of Immunology and Clinical Biochemistry 3FM CU (12-IMUN)
Faculty:	Third Faculty of Medicine
Actual:	from 2016
Semester:	summer
Points:	1
E-Credits:	1
Examination process:	summer s.:
Hours per week, examination:	summer s.:0/30, other [HS]
Capacity:	unknown / unknown (unknown)
Min. number of students:	unlimited
4EU+:	no
Virtual mobility / capacity:	no
Key competences:
State of the course:	not taught
Language:	Czech
Teaching methods:	full-time
Teaching methods:	full-time
Level:
Additional information:	http://www.lf3.cuni.cz/studium/materialy/imunologie/

Guarantor:	doc. MUDr. Petr Kučera, Ph.D. MUDr. Milada Cvačková doc. MUDr. Jan Novák, Ph.D.
Classification:	Medicine > Clinical Disciplines
Attributes:	Modul IIC

Examination dates Schedule

Annotation -

Last update: KUCERA2 (20.05.2008)

Problem oriented course, as a part of Module Basic Clinical Problems. Basis of pathologic anatomy, physiology and pharmacology related to immunopathology disorders are taught. Clinical Cases are used during seminars. Basic, typical clinical symptoms, typical laboratory findings and immunotherapeutic approaches are discussed.

Aim of the course -

Last update: KUCERA2 (20.05.2008)

The capacity to understand pathology, pathophysiology of immunde disorders, evaluation of clinical symptoms, indication and interpretation of laboratory immune tests is the aim of the subject. This knowledge will help to recognize, explain, diagnose immunopathology diseases and to propose the therapeutic approach in the clinical part of the studies (Clinical Science).

Literature -

Last update: KUCERA2 (30.05.2008)

Medical Immunology. Parslow TG, Stites DP, Terr AI,. - 10th ed. - London: Mc Graw-Hill, 2001.

Essentials of Clinical Immunology, Chapel H, Haeney M et al. Blackwell Science, 4th ed. 1999

Primer on Allergic and Immunologic Diseases , Shearer WT, Li JT, J Allergy Clinical Immunology. 2003, 111, 2, Supplement

Last update: KUCERA2 (22.02.2008)

Základní doporučená literatura:

J. Krejsek, O. Kopecký: Klinická imunologie, Nukleus HK, 2004

D. Stites, A.I. Terr Základní a klinická imunologie, Appleton a Lange, 1993

T. Fučíková Klinická imunologie v praxi, Galén 1997

T. Fučíková a kol. Základy klinické imunologie, RDI Press 1994

J. Bartůňková. Imunodeficience, Grada 2002, 2007

Alergie, časopis pro postgraduální vzdělávání, Tigis (www.tigis.cz)

Doporučená literatura jako možný literární zdroj k seminární práci:

Basic and Clinical Immunology:

Abbas A et al. Cellular and molecular Immunology, Saunders, 2005 or later (also short version)

Janeway Ch, et al. Immunobiology, 2005 or later

Chapel H. Clinical Immunology, 2006

Rich R et al, Clinical Immunology 2008

Schoenfeld Y., Autoimmune Diseases and Treatment : organ specific and systemic disorders (2006)

Annals of Allergy, Asthma & Immunology May 2005, Volume 94, Number 5, Supplement 1: Practice Parameter for the Diagnosis and Management of Primary Immunodeficiency

Akdis CA, Blaser K, Akdis M. Apoptosis in tissue inflammation and allergic disease. Curr Opin Immunol 2004; 16: 717-23.

Andrian UH, Mackay CR. T-Cell Function and Migration ? Two Sides of the Same Coin. N Engl J Med 2000; 343:1020*

Bellinghausen I, Metz G, Enk AH, Christmann S, Knop J, Saloga J. Insect venom immunotherapy induces interleukin-10 production and a Th2-to-Th1 shift, and changes surface marker expression in venom-allergic subjects. Eur J Immunol 1997; 27: 1131-9.

??Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006:11; 441: 235-8.

Marciano BE, Rosenzweig SD, Kleiner DE, Anderson VL, Darnell DN, Anaya-O'Brien S, Hilligoss DM, Malech HL, Gallin JI, Holland SM. Gastrointestinal involvement in chronic granulomatous disease. Pediatrics 2004; 114; 462-8.

Chapel H, Geha R, Rosen F for the IUIS PID Classification Commitee. Primary immunodeficiency diseases: an update. Clin Exp Immunol 2003; 132: 9-15.

Cicardi M, Zingale LC. The deficiency of C1 inhibitor and its treatment. Immunobiology 2007; 212: 325-31.

Conley ME, Howard V. Clinical findings leading to the diagnosis of X-linked agammaglobulinemia. J Pediatrics 2002; 141: 566-571.

Cunningham-Rundles C, Bodian Carol. Common Variable Immunodeficiency: Clinical and Immunological Features of 248 patients. Clin Immunol 1999; 92: 34-48.

Black CM. Scleroderma-clinical aspects. J Intern Med 1993; 234: 115-8 ??Cervera R, Piette JC, Font J, Khamashta MA, Shoenfeld Y, Camps MT, Jacobsen S, Lakos G, Tincani A, Kontopoulou-Griva I, Galeazzi M, Meroni PL, Derksen RH, de Groot PG, Gromnica-Ihle

E, Baleva M, Mosca M, Bombardieri S, Houssiau F, Gris JC, Quéré I, Hachulla E, Vasconcelos C, Roch B, Fernández-Nebro A, Boffa MC, Hughes GR, Ingelmo M; Euro-Phospholipid Project Group. Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients. Arthritis Rheum 2002; 46: 1019-27.

Finazzi G, Brancaccio V, Moia M, Ciaverella N, Mazzucconi MG, Schinco PC, Ruggeri M, Pogliani EM, Gamba G, Rossi E, Baudo F, Manotti C, D'Angelo A, Palareti G, De Stefano V, Berrettini M, Barbui T. Natural history and risk factors for thrombosis in 360 patients with antiphospholipid antibodies: a four-year prospective study from the Italian Registry. Am J Med 1996; 100: 530-6.

Hagen EC, Daha MR, Hermans J, Andrassy K, Csernok E, Gaskin G, Lesavre P, Lüdemann J, Rasmussen N, Sinico RA, Wiik A, van der Woude FJ. Diagnostic value of standardized assays for anti-neutrophil cytoplasmic antibodies in idiopatic systemic vascultits. EC/BCR Project for ANCA Assay Standardization. Kidney Int 1998; 53: 743-53.

Allergology:

Middleton E et al: etc. Allergy, principles and practice 2005

Kay B et al. Allergy and allergic diseases, 2008

Specific topics:

Müller U. Insect sting Allergy. Gustav Fischer Verlag, Stuttgart New York 1990.

Pichler WJ (edt) Drug Hypersensitivity, Karger 2007

Lockey RF, Bukantz SC, Bousquet J. Allergens and allergen immunotherapy, 3rd edition, New York, Basel, 2004.

Bernstein IL, Chan Yeung M, Malo JL, Bernstein DI. Asthma in the work place. Eds Taylor Francis, New York, London, 2006.

Teaching methods -

Last update: KUCERA2 (20.05.2008)

The Course consists from Seminars, Case studies discussions, indications and interpretation of particular laboratory immune tests, demonstration of some clinical diagnostic procedures at the clinic. Active participation of all students is required

Requirements to the exam -

Last update: doc. MUDr. Petr Kučera, Ph.D. (05.01.2012)

Credit:
1. The student will briefly present the paper to the teacher to demonstrate the ability to discuss the topic of the paper.

2. Questions from topics of the course

Terms and localization of credit examination will be posted on the Board of Dept Immunology (near Room 440 - secretary) approx. 2 weeks after the course end.

Syllabus -

Last update: doc. MUDr. Petr Kučera, Ph.D. (05.01.2012)

Introduction, immune system and human diseases.
Immunology laboratory diagnostics, indication and interpretation of laboratory tests.
Immunodeficiency primary and secondary
Autoimmune diseases organ nonspecific ? rheumatic diseases, immunocomplex diseases, vasculitis.
Autoimmune diseases organ specific ? endocrine, renal, GI, neuromuscular and reproductive diseases
Allergy diseases and anaphylaxis
Immunology of transplantation. Tumor immunology
Immunohematology and lymphoproliferation.
Basic principles of immunotherapy

Seminar paper:
Short review from the literature of about 4-5 pages, appropriate structure, formal aspects and references (please start with the textbook, than Medline search and fulltexts from the school). Example of reference from peer-rewied journal:. Dlouhý P, Kučera P, Kraml P, Pompachová A, Potočková J, Šmejkalová V, Mokrejš P, Jaček M, Anděl M.. Short-Term Dietary Intake of C18:1 Trans Fatty Acids Decrease the Function of Cellular Immunity in Healthy Young Men, Ann Nutrition Metab, 2008, 53, 129-136.) The paper can be written in pairs.
Topics are selected from the recommended areas. In special cases the student can discuss different topic with the head of the course on the course beginning. The paper has to deal with immunology aspect of phenomenon, disease, diagnostics test or therapy. The seminar paper due is the last day of the Course

Entry requirements -

Last update: KUCERA2 (30.05.2008)

The knowledge from the Module IB (Cell and Molecular Immunology) and Module IIA (Immunopathology) is required. There is no room for extensive reviewing of these basics.