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IB - Medical Chemistry and Biochemistry - CCBGCH21
Title: IB - Lékařská chemie a biochemie
Guaranteed by: Department of Biochemistry, Cell and Molecular Biology 3FM CU (12-BIOC)
Faculty: Third Faculty of Medicine
Actual: from 2016
Semester: winter
Points: 5
E-Credits: 5
Examination process: winter s.:
Hours per week, examination: winter s.:48/45, other [HS]
Extent per academic year: 90 [hours]
Capacity: unknown / unknown (unknown)
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
Key competences:  
State of the course: not taught
Language: Czech
Teaching methods: full-time
Teaching methods: full-time
Level:  
Additional information: http://www.lf3.cuni.cz/cs/pracoviste/chemie/index.html
Guarantor: prof. RNDr. Eva Samcová, CSc.
Mgr. Vladimíra Kvasnicová
Classification: Medicine > Basic Sciences
Attributes: Modul IB
Examination dates   Schedule   
Annotation -
Last update: Mgr. Vladimíra Kvasnicová (03.10.2010)
The course Medical chemistry and biochemistry is taught as a part of the subject Module IB - Cell biology and genetics, it is scheduled during 1st semester only. The course opens with a general chemistry, but moust of the teaching is focused on fundamentals of biochemistry - structures, properties and metabolism of coumpounds found in the human body. The course is finished by the summary of regulation of biochemical processes on the cellular level.
Aim of the course -
Last update: Mgr. Vladimíra Kvasnicová (03.10.2010)

The aim of this course is to provide medical students with basic knowledge of chemistry and biochemistry necessary for an understanding of processes taking place in the human body. The main focus is on the chemical composition of cells and principles of chemical reactions. This course provides essential background knowledge for other courses in Module IB. You will also build on facts and skills acquired in this course in later course such as the biochemistry course in Module IA, in pharmacology, clinical biochemistry, etc.
Literature -
Last update: Mgr. Vladimíra Kvasnicová (03.10.2010)

CHEMISTRY
* any secondary school textbook of Chemistry containing both inorganic and organic chemistry

BIOCHEMISTRY 
* Murray, Robert K.: Harper´s biochemistry,24th ed. (or later), 1996, ISBN 0838563115
* Pamela C. Champe, Richard A. Harvey: Lippincott´s Illustrated Reviews - Biochemistry, ISBN 0-397-51091-8
* Jan Koolman, Klaus-Heinrich Röhm: Color Atlas of Biochemistry, Thieme, Stuttgard, 1996, ISBN 3-13-100371-5
* J.G.Salway: Metabolism at a Glance, 2nd ed., Blackwell Science Ltd, 1999, ISBN 0-632-05274-0
* Thomas M. Devlin et al.: Textbook of Biochemistry With Clinical Correlations, 4th ed., ISBN 0-471-15451-2
Teaching methods -
Last update: Mgr. Vladimíra Kvasnicová (03.10.2010)

Lectures (24 x 2 hours), seminars (11 x 3 hours), practicals (4 x 3 hours), altogether 93 hours of teaching during 15 study weeks.
Requirements to the exam -
Last update: Mgr. Vladimíra Kvasnicová (28.04.2011)

This course ends in the end of the winter semester with a sub-credit (colloquium), which is necessary to get credit for the whole Module IB. The exam in Module IB takes place at the end of the first year but there are no more classes in the course Medical Chemistry and Biochemistry in the summer semester.

NOTE:
Students can sign up for the Module IB exam only after they have received credit in Module IB both for the winter and summer semester and have it confirmed in the "Index" book. For this reason we strongly recommend that you fulfill the requirements for the sub-credit in the winter semester.

SUBCREDIT REQUIREMENTS

  •  attendance in all practicals
  •  pass mark on both credit tests

Deailed information about practicals and tests can be found at http://www.lf3.cuni.cz/en/departments/chemie/vyuka/index.html.

PRACTICALS
Practicals take place from the 7th till the 10th week of the winter semester. Complete reports from practicals must be handed in before the Christmas break at the latest. Adequate theoretical preparation for practicals is required for attending the practical - students are tested before starting their assignment. If you cannot attend a practical an additional opportunity will be scheduled at the end of the winter semester.

TESTS
When siting a test you are only allowed a pen and for test 1 a calculator. You will be asked for a photo ID before sitting a test.

  • Credit test 1 (chemical calculations and nomenclature) - sat in the 6th week of the winter semester as scheduled, time available: 90 min.; pass mark is 70 %; type of test: short answers
  • Credit test 2 (medical chemistry and biochemistry) - sat in the examination period as scheduled, time available: 60 min; pass mark is 60%; type of test: multiple-choice questions

HOW MANY TIMES YOU CAN SIT A TEST
You can sit each test three times at the most. You must sign up beforehand for tests in the exam period: see the chemistry notice board (4th floor). There are three opportunities to sit the tests in the winter semester and two in the summer semester - you can choose any of them. You can sit both tests at the same time (available time 150 min). Those who fail three times will be given a last chance after the summer break (beginning of September).

SIGNING SUB-CREDITS INTO CREDIT BOOKS (INDEX)
Dates for signing Module IB subcredit for the Medical chemistry and biochemistry course in the Index will be posted on the chemistry notice board on level 4. The following teachers are responsible for signing the Index for the following groups:

  • Vladimíra Kvasnicová (room 411): group 3
  • Hana Logerová (room 617): groups 1 and 4
  • Jan Trnka (room 410): group 2
Syllabus -
Last update: Mgr. Vladimíra Kvasnicová (03.10.2010)

LECTURES
1) Introduction to medical biochemistry
2) Structure of atoms and molecules
3) Thermodynamics and chemical kinetics
4) Chemical equilibriums
5) Structure and reactions of organic compounds
6) Structure and properties of proteins
7) Enzymes
8) Respiratory chain, macroergic phosphates
9) Citric acid cycle
10) Structure and properties of saccharides
11) Metabolism of saccharides I
12) Metabolism of saccharides II
13) Extracellular matrix
14) Biochemistry of muscle cells
15) Structure and properties of lipids
16) Structure and function of membranes
17) Metabolism of lipids I
18) Metabolism of lipids II
19) Metabolism of steroids
20) Heterocyclic compounds, structure of nucleotides
21) Metabolism of purine and pyrimidine bases
22) Metabolism of amino acids
23) Metabolism of tetrapyrrols
24) Regulation of biochemical processes in the cell

SEMINARS
1) From periodic table to chemical composition of cells
2) Chemical calculations I (expression of concentration, conversion of concentrations, osmolarity, dilution)
3) Chemical calculations II (pH of  both weak and strong acids and bases, pH of buffers)
4) Basic terms of medical chemistry. Important reactions of organic compounds, enzymes.
5) Analytical methods (spectrophotometry, chromatography, volumetric analysis, potentiometry)
6) Preparation to practical trainings, laboratory safety regulations, laboratory tools
7) Compartmentalization of biochemical processes in cells. Regulation of enzyme activity.
8) Mitochondria
9) Structure and metabolism of saccharides, clinical correlations
10) Structure and metabolism of lipids, clinical correlations
11) Metabolism of nitrogen containing compounds, clinical correlations

PRACTICALS
1) Spectrophotometry - Determination of urine creatinine
2) Chromatography - TLC, HPLC, GC
3) Volumetric analysis - Determination of gastric juice acidity
4) Potentiometry - Measuring of phosphate buffer pH
Entry requirements -
Last update: Mgr. Vladimíra Kvasnicová (03.10.2010)

Hight school chemistry.
 
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