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Course, academic year 2023/2024
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Clinical Biochemistry - B80114 (General Medicine - English parallel)
Title: Clinical Biochemistry
Guaranteed by: Institute of Medical Biochemistry and Laboratory Diagnostics First Faculty of Medicine Charles University and General University Hospital in Prague (11-00410)
Faculty: First Faculty of Medicine
Actual: from 2023
Semester: winter
Points: 2
E-Credits: 2
Examination process: winter s.:
Hours per week, examination: winter s.:0/25, C+Ex [HS]
Extent per academic year: 25 [hours]
Capacity: unlimited
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
State of the course: taught
Language: English
Teaching methods: full-time
Teaching methods: full-time
Explanation: odb.as.MUDr Ivan Šebesta,CSc
Old code: 114
Guarantor: prof. MUDr. Tomáš Zima, DrSc., MBA
Comes under: Compulsory for GM 5.y._23/24
Attributes: Lékařství
Klinický předmět
Pre-requisite : {Patobiochemie pro ALEK jako prerekvizita}, B83161, B83162
Annotation
Last update: Jana Kolářová (05.03.2021)
Clinical case studies from all medical fields with an emphasis on laboratory tests results. The aim of the subject is to practice the indication and interpretation of laboratory tests. Discussions take place and students will be asked to: a) establishment of diagnosis, b) differential diagnosis, c) suggestion of further investigations, d) suggestion of therapy.
Literature
Last update: MUDr. Ivan Šebesta, CSc. (13.09.2023)

Obligatory:

  • Gaw, Allan. Clinical biochemistry : an illustrated colour text. Edinburgh: Churchill Livingstone/Elsevier, 2013, 187 s. ISBN 978-0-7020-5179-1.
  • Rifai, Nader, Horvath, Andrea R. Wittwer, C. (eds.). Clinical chemistry and molecular diagnostics. : Elsevier Books, 2018, 1867 s. ISBN 978-0-323-35921-4.
  • BHAGAVAN, N. V. Essentials of Medical Biochemistry With Clinical Cases: Second Edition. : Elsevier, 2015, 752 s. ISBN 0124166873.
  • WILLIAMSON, MARY A., SNYDER, L. MICHAEL. Wallach's Interpretation of Diagnostic Tests: Pathways to Arriving at a Clinical Diagnosis (Interpretation of Diagnostric Tests). : Wolters Kluwer, 2015, 1288 s. ISBN 978-1451191769.
  • FISCHBACH, FRANCES T., FISCHBACH, MARGARET, A. Fischbach's A Manual of Laboratory and Diagnostic Tests. : Wolters Kluwer, 2017, 1224 s. ISBN 978-1496377128.

Requirements to the exam
Last update: MUDr. Ivan Šebesta, CSc. (13.09.2023)

Information for students of study groups: 5051,5052 

- teaching starts on Monday 2nd October 2023 at 8,00 a.m.

- at Kateřinská 32, Inst Med Biochem Lab Dg (ÚLBLD)  ground floor, room No. 1.089.    

All lectures are presented on the Institute website: Přednášky ke stažení - Ústav lékařské biochemie a laboratorní diagnostiky (cuni.cz)     

Questions Clinical biochemistry , 5th year, foreign students :


Proteins in plasma, albumin, total protein
Sodium, potassium, chloride, calcium, phosphate, magnesium
Water homeostasis, effective osmolality and its disorders 

Acid base balance

Monitoring scope in the intensive care

Glucose in blood and urine, ketone bodies, lactate
Tests for diabetes mellitus (oGTT,insulin,C-peptide,GAD Ab,HbA1,AGE and others)
Urinalysis, examination of the urinary sediment
Investigation of the lipid disorders
Assessment of the antioxidants capacity, acute - phase reactants

Iron, transferrin, ferritin

Investigations of the impairment of the hepatocytes

Investigation of the porphyrias

Investigation of the small intestine, function tests in gastroenterology
Screening tests in gastroenterology

Examination in endocrinology
Tumor markers
Trace elements
Investigation of cerebrospinal fluid

 

Preanalytical variables, preparing of the patient, collection of the specimen

Biological influences on the laboratory results

Point of care testing, dry chemistry

Urgent tests
Basic principles of the laboratory techniques, photometry, chromatography, ELISA

Therapeutic drug monitoring, drug screening

Investigation and dif.dg. of the bone diseases

Differential diagnosis  of hyperbilirubinaemia and jaundice
Dif.dg. of acute heart diseases

Metabolic syndrome, dif.dg. of hyper and hypouricaemia
Dif.dg. of pancreas impairment
Assessment of renal function, dif.dg. of renal failure

Dif.dg. of proteinuria

Investigation and dif.dg. of urolithiasis
Screening of congenital defects
Inborn errors of metabolism, basic indications for investigation, phenylketonuria
Cytogenetic analysis and its meaning in different clinical specialities
Laboratory control of anticoagulants treatment

Anemias

Preparation of samples for direct detection of infectious agens

Basic principles of proper use of antibiotics

 

 

Education plan -
Schedule block
Week of the block Day From - To Education type Theme Teacher Files Note Hodnocení
4Monday08:00 - 09:15seminarToxicology,therapeutic drug monitoringdoc. Ing. Drahomíra Springer, Ph.D. 
průměr: 4, hodnoceno: 5x
09:25 - 11:20seminarOrganization of teaching (exam terms). The impact of preanalytical variables on quality of laboratory results.Indication and interpretation of laboratory tests. POCT. Metabolic disorders.MUDr. Ivan Šebesta, CSc. The seminars will take place at lecture hall of Inst Med Bioch Lab Dg,Kateřinská 32, (Dean´s office building,ground floor,door No.1.089) on : 2nd - 6th October 2023 (1th week of teaching) for study groups 5051+5052; 6th - 10th May 2024 for 5053+5054 . Clinical case studies with emphasis on laboratory tests results will be presented. Students will be asked for a ) establishment of diagnosis, b) differential diagnosis, c) suggestion of further investigations , d) suggestion of therapy
průměr: 5, hodnoceno: 6x
11:30 - 13:00seminarTumor markers. Interpretation of results with psychosomatic overlap.prof. MUDr. Marta Kalousová, Ph.D. 
průměr: 4, hodnoceno: 4x
Tuesday08:00 - 09:00seminarCerebrospinal fluidprof. MUDr. Marta Kalousová, Ph.D. 
průměr: 4, hodnoceno: 3x
09:05 - 10:30seminarInborn errors of metabolism.doc. RNDr. MUDr. Pavel Ješina, Ph.D. 
průměr: 4, hodnoceno: 3x
10:35 - 13:00seminarGastroenterologyMUDr. Petr Kocna, CSc. 
průměr: 4, hodnoceno: 3x
Wednesday08:00 - 09:45seminarHepatology.prof. MUDr. Libor Vítek, Ph.D. 
průměr: 3, hodnoceno: 3x
09:50 - 11:15seminarHematology.doc. MUDr. Tomáš Kvasnička, CSc. 
průměr: 3, hodnoceno: 2x
11:20 - 13:00seminarDiabetes mellitus,Endocrinology,osteologyMUDr. Zdislava Vaníčková 
průměr: 4, hodnoceno: 1x
Thursday08:00 - 10:00seminarAcid base balance.Hydration,osmolality.The teacher is: Svobodova,MD
průměr: 4, hodnoceno: 3x
10:15 - 12:00seminarMonitoring scope in the intensive care.doc. MUDr. Helena Lahoda Brodská, Ph.D. 
průměr: 5, hodnoceno: 2x
12:05 - 13:00seminarMicrobiology.The teacher is: MUDr.Adámková,Ph.D.
průměr: 5, hodnoceno: 1x
Friday08:00 - 09:00seminarScreening of inborn defects.doc. Ing. Drahomíra Springer, Ph.D. 
průměr: 5, hodnoceno: 1x
09:15 - 10:15seminarClassical and oncological genetics.The teacher is : RNDr.Lizcová,Ph.D.
průměr: 5, hodnoceno: 1x
10:30 - 12:15seminarNephrology,inflammation,oxidative stress. prof. MUDr. Tomáš Zima, DrSc., MBAThis seminar also teaches: prof.MUDr.M.Kalousová,Ph.D. Course-unit credit - Dr.I.Šebesta,Ph.D.
průměr: 4, hodnoceno: 1x
 
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