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The characteristics of individual phases of radiobiological mechanism in cells, the description of models. The model chain, inactivation effects, the survival curve. The meaning of given models for the optimization of radiotherapy in treatment of cancer diseases and for the radiation hygiene.
Last update: T_UCJF (21.05.2001)
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Složení ústní zkoušky. Last update: Krtička Milan, doc. Mgr., Ph.D. (10.06.2019)
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Nias A.H.W.: An introduction to radiobiology, Wiley, Chichester, 2000 Alpen E.L.: Radiation Biophysics, Academic Press, San Diego, 1998 Lehnert, S.: Biomolecular action of ionizing radiation, Taylor&Francis, 2008 Mozumder, A.: Fundamentals of Radiation Chemistry, Academic Press, San Diego, 1999 Mozumder, A., Hatano, Y. Charged particle and photon interactions with matter: Chemical, Physicochemical, and Biological Consequences with Applications, Marcel Dekker Inc, 2004 Steel, G.G.: Basic Clinical Radiobiology, 5th Edition, Michael C. Joiner, Albert J. van der Kogel, CRC Press, 2018 Alberts B., Bray D., Lewis J., Raff M., Roberts K., Watson J.D.: Molecular Biology of the Cell, Garland Publ., NY 1994 Eric J. Hall, Amato J. Giaccia, Radiobiology for the Radiologist Eighth, North American Edition, 2018 Původní publikace v odborných časopisech od 1990
Last update: Krtička Milan, doc. Mgr., Ph.D. (14.01.2019)
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Požadavky ke zkoušce odpovídají sylabu předmětu v rozsahu prezentovaném na přednášce. Last update: Krtička Milan, doc. Mgr., Ph.D. (10.06.2019)
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Basic characteristics of radiobiological mechanism in cells and tissues. Attempts of modeling it mathematically in the past century. Survival curves and factors influencing radiobiological mechanism; especially oxygen enhancement ratio. Individual phases of the given mechanism: physical, chemical and biological; and corresponding model chain. Microdosimetric characteristics and radiation energy transfer to the medium; influence of different radiomodificators; final radiobiological effect (cell inactivation and other consequences). Cumulative effect in the irradiated tissue; radiotherapy of tumors. Radiobiological mechanism in cells; double-strand breaks of chromosomal DNA. Detailed shape of survival curves; importance for optimization of radiotherapy approaches and radiation hygiene (including protection of astronauts). Application of different kinds of ionizing particles in tumor radiotherapy; hadrontherapy. Last update: T_UCJF (28.05.2003)
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