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The lectures can be given in English. Protein-protein and protein-DNA interactions play central roles in signal and energy transduction within the cell. In the first part, the course reviews principal signaling pathways such as calcium and phospholipid signaling, trimeric G-protein coupled signaling, MAPK cascades, or growth factor receptor signaling, among others. In the second and main part, important classes of regulatory proteins are presented in more detail, illustrating the structure-function relationship, significance for oncogenesis, and latest advancements in the field. Major topics: Protein serine kinases, protein tyrosine kinases, lipid kinases, phospholipases, adenylate and guanylate cyclases, protein domains important in signaling, growth factor and cytokine receptors, adaptor proteins, small G proteins, MAPK cascades, focal adhesion signaling, important classes of transcription factors and their modes of regulation, coactivators of transcription factors, complexes for modification and remodeling of chromatin, preinitiation complex of RNAPolII, nuclear structure and gene expression. MOLECULAR CELL BIOLOGY, 4th edition, 2000, LODISH, H., BERK, A., ZIPURSKY, S.L., MATSUDAIRA, P., BALTIMORE, D., DARNELL; J. W. H. Freeman and Company, New York; ISBN 0-7167-3136-3 Protein kinase functions, J. Woodget, Oxford University Press; ISBN 0-19-963770-9 Protein-Protein recognition, C. Kleanthous, Oxford University Press; ISBN 0-19-963760-1.
Last update: Folk Petr, doc. RNDr., CSc. (06.07.2021)
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Biochemistry of Signal Transduction and Regulation, Second Edition, 2001, G. Kraus ISBN: 3-527-30378 (softcover); 3-527-60005-1 (electronic) vybrané kapitoly
Introduction to Protein Structure, Second Edition, 1999, C. Branden, J. Tooze ISBN: 0-8153-2305-0 vybrané kapitoly
Frontiers in Molecular Biology Serie: Protein Kinase Functions, 2000, J. Woodget, ed. ISBN: 0-19-963770-9 Protein/Protein Recognition, 2000, C. Kleanthous ISBN: 0-19-963760-1 Chromatin Structure and Gene Expression, Second ed., 2000, S.C.R. Elgin & J.L. Workman eds. ISBN: 0-19-963890-X vybrané kapitoly
Topikální přehledné články
Science Transduction Knowledge Environment
Prerequisites a literatura pro všeobecný přehled o problematice : Molecular Biology of the Cell, Fourth Edition, 2002, B. Alberts et al. ISBN: 0-8153-4072-9 Parts I-3 - Proteins II-7 - Control of Gene Expression IV-15 - Cell Communication Kapitoly o přenosu signálu/ molekulární fyziologii v učebnicích Cell and Molecular Biology, Biochemistry atp. Last update: Šebková Nataša, RNDr., Ph.D. (21.02.2018)
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Zkouška je ústní z celého rozsahu přednášené látky. Předpokládány jsou elementární znalosti z biochemie a buněčné biologie. Last update: Půta František, doc. RNDr., CSc. (25.04.2012)
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Up-to-date english version of the syllabus is available upon request. Last update: Folk Petr, doc. RNDr., CSc. (06.07.2021)
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