Genetics - GAF284
Title: Genetika
Guaranteed by: Department of Biological and Medical Sciences (16-16150)
Faculty: Faculty of Pharmacy in Hradec Králové
Actual: from 2019
Semester: summer
Points: 0
E-Credits: 3
Examination process: summer s.:oral
Hours per week, examination: summer s.:14/14, C+Ex [HS]
Capacity: unknown / unknown (unknown)
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
Key competences:  
State of the course: not taught
Language: English
Teaching methods: full-time
Level:  
Explanation: 1.roč. F
Note: deregister from the exam date if a requisite was not fulfilled
course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: PharmDr. Eva Doleželová, Ph.D.
Co-requisite : GAF283
Is co-requisite for: GAF144
Examination dates   Schedule   
Annotation -
Genetics is a young science that has grown since the beginning of the 20th century in a way that now has a key place in the whole biology. It explains the rules of transfering of hereditary traits from the parental generation to the offspring, deals with the mechanism of their transfer, and explains why offsprings are in many ways different from their parents and why they differ from each other. The aim of the subject is to provide students with a comprehensible introduction to important areas of genetics - general, molecular, evolutionary and population. Topics: DNA and chromosomes, Mendelian laws, population genetics, evolutionary genetics, genetic diseases, mutations, DNA replication, expression of genetic information, parasexual processes of bacteria, viruses.
Last update: Doleželová Eva, PharmDr., Ph.D. (20.12.2017)
Course completion requirements -

The condition of obtaining the credit is to meet the following conditions: obligatory presence in all practical classes. The only apology is illness confirmed by the physician, but not more than twice. In case of illness student has to write an extra seminar work from missing practical classes.

Last update: Doleželová Eva, PharmDr., Ph.D. (20.12.2017)
Literature -

Obligatory:

  • Alberts, Bruce, Hunt, Tim, Johnson, Alexander Lewis, Julian, Morgan, David Owen, Raff, Martin C., Roberts, Keith et al.. Molecular biology of the cell. null: null, 2015, 1342 s. ISBN 978-0-8153-4464-3.

  • Genetics

Recommended:

  • Snustad, D. Peter, Simmons, Michael J.. Principles of genetics. Hoboken: Wiley, 2012, 766 s. ISBN 978-1-118-09242-2.

Last update: prepocet_literatura.php (19.09.2024)
Teaching methods -

Lectures

Lab classes - model organisms (Drosophila melanogaster), preparation and microscopy of the salivary glands of Drosophila melanogaster, Mendel a Morgan – principles of inheritance, autosomal and gonosomal inheritance, cytogenetics, hybridization cytogenetic methods

Last update: Doleželová Eva, PharmDr., Ph.D. (20.12.2017)
Requirements to the exam -

Form of an exam is test composed of 25 questions (21 from theory + 4 from practical classes).

Types of questions: multiple choice (1-4 correct answers), answering, explanatory, image description.

  • limit for passing the test: 70% of correct answers

  • evaluation: excellent: 100 % - 90 %

     very good: 89 % - 80 %

     good: 79 % - 70 %

Student should show knowledge across the subject Genetics, specifically in the following areas:

  1. structure of DNA

  2. genic and nongenic DNA

  3. chromosome structure in prokaryotes and viruses

  4. chromosome structure in eukaryotes

  5. principle of DNA replication

  6. replication machine - proteins of  replication fork

  7. definition of terms of inheritance

  8. Mendel’s study of heredity

  9. Mendelian laws

  10. applications of Mendel’s principles

  11. interaction of paired alleles – dominance, recessivity, codominance, incomplete dominance

  12. the chromosomal basis of Mendelism – Morgan

  13. polygenic inheritance

  14. genotype - environment interaction

  15. population genetics

  16. Hardy-Weinberg equilibrium

  17. evolutionary factors

  18. extranuclear heredity

  19. genetic diseases

  20. gene mutations

  21. chromosomal mutations

  22. genomic mutations

  23. mutations and diseases

  24. transcription – prokaryotes, eukaryotes

  25. posttranscriptional modification of mRNA, tRNA, rRNA

  26. translation

  27. posttranslational processing

  28. transformation of bacteria

  29. conjugation of bacteria

  30. transduction of bacteria

  31. structure of virion

  32. structure of bacteriophage

  33. viral genome

  34. reproduction of viruses - lytic and lysogenic cycle

  35. retroviruses

 

Last update: Doleželová Eva, PharmDr., Ph.D. (15.01.2018)
Syllabus -

DNA and chromosomes

  • structure of DNA
  • genic and nongenic DNA
  • chromosome structure in prokaryotes, viruses, and eukaryotes

Inheritance I

  • definition of terms
  • Mendel’s study of heredity
    • Mendelian laws
    • applications of Mendel’s principles
  • interaction of paired alleles – dominance, recessivity, codominance, incomplete dominance
  • the chromosomal basis of Mendelism – Morgan
  • polygenic inheritance
  • genotype-environment interaction

Inheritance II

  • population genetics
    • Hardy-Weinberg equilibrium
    • evolutionary factors
  • extranuclear heredity
  • genetic diseases

Mutations

  • gene mutations
  • chromosomal mutations
  • genomic mutations
  • mutations and diseases

Replication of DNA

  • principle of DNA replication
  • replication machine - proteins of replication fork

Expression of genetic information

  • transcription – prokaryotes, eukaryotes
  • posttranscriptional modification of mRNA, tRNA, rRNA
  • translation
  • posttranslational processing

Parasexual processes of bacteria

  • transformation
  • conjugation
  • transduction

Viruses

  • structure of virion
  • structure of bacteriophage
  • viral genome
  • reproduction of viruses - lytic and lysogenic cycle
  • retroviruses
Last update: Doleželová Eva, PharmDr., Ph.D. (20.12.2017)