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Molecular aspects of cell signaling, its disorders and clinical implications - CCOCA0010
Title: Molekulární aspekty buněčné signalizace, její poruchy a klinické dopady
Guaranteed by: Department of Pneumology 3FM CU and UHB (12-PNEU)
Faculty: Third Faculty of Medicine
Actual: from 2016
Semester: summer
Points: 1
E-Credits: 1
Examination process: summer s.:
Hours per week, examination: summer s.:0/15, C [HS]
Extent per academic year: 15 [hours]
Capacity: unknown / unknown (20)
Min. number of students: 3
4EU+: no
Virtual mobility / capacity: no
Key competences:  
State of the course: not taught
Language: Czech
Teaching methods: full-time
Level:  
Guarantor: doc. MUDr. Evžen Křepela, CSc.
Examination dates   Schedule   
Annotation -
The aim of this one-semester course is to provide the students the basic overview on mechanisms and functions of molecular signaling in cells, its disorders and clinical implications.
Last update: Křepela Evžen, doc. MUDr., CSc. (29.05.2015)
Aim of the course -

 

The aim of the course is to provide the students the basic overview on different molecular signaling pathways, their mechamisms and regulations and on their role in physiology and pathogenesis of diseases.

 

Last update: Křepela Evžen, doc. MUDr., CSc. (29.05.2015)
Literature -

) Runge M.S. and Patterson C. Principles of Molecular Medicine. 2nd Edition. Humana  Press, New Jersey, 2006.
2) Kraus G. Biochemistry of Signal Transduction and Regulation. Wiley, New York, 2008.
3) Voet D. and Voet J.G. Biochemistry. 4th Edition. Wiley, New York, 2011.

Last update: Křepela Evžen, doc. MUDr., CSc. (29.05.2015)
Teaching methods -

Lectures.

Last update: Křepela Evžen, doc. MUDr., CSc. (29.05.2015)
Requirements to the exam -

Attendance of 90% and passing the written test with 60% correct answers are required.

Last update: Křepela Evžen, doc. MUDr., CSc. (29.05.2015)
Syllabus -

 

Charakterization of signaling molecules, signal receptors, signal pathways and molecular effector responses to signal transduction. Signaling of G-protein coupled signal receptors. Signaling of tyrosine kinase receptors. Signaling of tyrosine kinase associated receptors. Nitric oxide signaling. Cytokine signaling. Nuclear receptor signaling. Adhesion receptor signaling. Hypoxia induced signaling. Apoptotic signaling. Signaling aspects of cholesterol biosynthesis regulation.

 

Last update: Křepela Evžen, doc. MUDr., CSc. (29.05.2015)
 
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