Interactions of proteins and membrane - introduction to soft matter - NBCM147

• Title: Interakce proteinů a membrán - úvod do soft matter
• Guaranteed by: Department of Chemical Physics and Optics (32-KCHFO)
• Faculty: Faculty of Mathematics and Physics
• Actual: from 2013
• Semester: winter
• E-Credits: 5
• Hours per week, examination: winter s.:2/1, C+Ex [HT]
• Capacity: unlimited
• Min. number of students: unlimited
• 4EU+: no
• Virtual mobility / capacity: no
• State of the course: taught
• Language: Czech
• Teaching methods: full-time
• Guarantor: RNDr. Robert Vácha, Ph.D.
• Teacher(s): RNDr. Robert Vácha, Ph.D.

Annotation

English

The course is focused on basic knowledge of interactions of proteins and membranes at coarse-grained level. It covers also development of appropriate soft matter models, their approximations and limitations. At the end, few advanced methods of Monte Carlo simulations that are often used in this field are described.

Last update: T_KCHFO (15.04.2013)

Czech

Předmět je zaměřen na základní znalosti z oboru interakcí membrán a proteinů na zhrubené úrovni. Přednášky zahrnují také popis vývoje modelů (membrán a proteinů), včetně jejich aproximací a omezení. Na závěr je shrnuto několik pokročilých metod Monte Carlo, které se často používají v simulacích.

Last update: T_KCHFO (15.04.2013)

Literature

English

• Intermolecular and Surface Forces 3rd edition by Jacob N. Israelachvili; Academic Press 2010

• Giant Molecules: Here, There, and Everywhere 2nd edition by Alexander Y. Grosberg et al.; World Scientific Press 2010

• Soft Condensed Matter Physics in Molecular and Cell Biology by W.C.K. Poon and D. Andelman; Taylor & Francis 2006

Last update: T_KCHFO (15.04.2013)

Syllabus

English

1. Introduction to soft matter

2. Ideal chain approximation

3. Ideal thin membrane

4. Interaction of uncharged membranes and proteins

5. Interaction of charged membranes and proteins

6. Towards realistic interactions of membranes and proteins

7. Thermodynamic principles of self-assembly

8. Langmuir adsorption

9. Transport phenomena

10. Advanced Monte Carlo

Last update: T_KCHFO (15.04.2013)

Czech

1. Úvod do oblasti "soft matter"

2. Idealní řetězec

3. Idealní tenká membrána

4. Interakce nenabitých membrán a proteinů

5. Interakce nabitých membrán a proteinů

6. Realistické interakce membrán a proteinů

7. Termodynamické principy samouspořádaných systémů

8. Langmuirova adsorpce

9. Transport

10. Pokročilé metody Monte Carlo

Last update: T_KCHFO (15.04.2013)