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Course, academic year 2018/2019
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Transfer and Conversion of Energy in Biosystems - NBCM004
Title in English: Transformace a přenos energie v biosystémech
Guaranteed by: Institute of Physics of Charles University (32-FUUK)
Faculty: Faculty of Mathematics and Physics
Actual: from 2014
Semester: winter
E-Credits: 3
Hours per week, examination: winter s.:2/0 Ex [hours/week]
Capacity: unlimited
Min. number of students: unlimited
State of the course: taught
Language: Czech
Teaching methods: full-time
Guarantor: prof. RNDr. Petr Heřman, CSc.
doc. RNDr. Jaroslav Večeř, CSc.
Classification: Physics > Biophysics and Chemical Physics
Annotation -
Last update: T_FUUK (10.03.2004)
Basic principles of bioenergetics in cells: thermodynamics of biochemical reactions, enzyme catalysis and regulation, membrane transport, respiratory chain, photosynthesis, neurons and transmition of electrical signals, photoreception, principles of muscle contraction, biomechanics.
Aim of the course -
Last update: HERMAN/MFF.CUNI.CZ (07.05.2008)

See annotation.

Literature -
Last update: T_FUUK (28.04.2008)

W.J.Moore, Fyzikální chemie, Praha, SNTL 1981

R.Ch. Cantor, P. R. Shimmel, Biophysical chemistry, W.H. Freeman & Co., San Francisko, 1980

B.Alberts,O.Bray, J.Lewis, M.Raff, K.Roberts, J.O. Watson, Molecular Biology of the Cell, Garland Publishing, Inc., New York, London, 1989

G.G.Hammes, Enzyme catalysis and regulation, Academic Press, New York, London, 1982

W.Hoppe, W.Lohman, H.Markl, H.Ziegler, Biophysics, Springer-Verlag, Berlin, Heidelberg, New York, Tokyo, 1983

P.R. Bergethon, E.R. Simons, Biophysical chemistry, Springer-Verlag, NY, 1990

J. Horák, A. Kotyk, K.Sigler, Biochemie transportních pochodů, Academia, Praha 1984

V. Kalous, Z. Pavlíček, Biofyzikální chemie, SNTL, Praha 1984

Teaching methods -
Last update: T_FUUK (12.05.2008)

lecture

Requirements to the exam - Czech
Last update: prof. RNDr. Petr Heřman, CSc. (06.10.2017)

Zkouška sestává z ústní části. Požadavky u ústní části zkoušky odpovídají sylabu předmětu v rozsahu, který byl prezentován na přednášce.

Syllabus -
Last update: T_FUUK (28.04.2004)

1. Thermodynamics of biochemical reactions
Biological cycle, energy and order, chemical potentials, activity, chemical affinity, chemical reactions, kinetics and equilibria, temperature dependence, theory of the transient complex, reversible and chain reactions, compartmental analysi

2. Enzyme catalysis and regulation
Chemical aspects of the enzyme catalysis, elementary steps, stady state kinetics, King-Altman method, one substrate one product, multiple substrates and products, regulation, allostery, models, effectors, inhibition, activation.

3. Membrane transport
Passive and active transport, uniport, symport, antiport, transporters, termodynamic aspects of the active transport, pores and channels, membrane potential, osmotic stability, intracellular pH, transport of macromolecules and particles, regulation

4. Respiratory chain
Structure and function of mitochondria, production of ATP, proton gradient

5. Photosynthesis
Structure and function of chloroplasts, antenae systemes, reaction center, electron transport, proton gradients, phosphorylation, sugar synthesis

6. The nervous system
Neurons, gated ion channels, action potential, neurotransmiters, postsynaptical potentials, synaptic modifications amd elliminations, grant postsynaptic potencial, adaptation, neuron networks

7. Vision
Molecular basis of the photoreception, vizual pigments, photoreceptors, ion channels, vizual excitation and adaptation, differences for vertebrata and invertebrata, role of calcium

8. Active movement
Muscle cells, actine and myosine, contraction role of calcium nad ATP, cellular and intracellular movement, microtubules, cilia

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