SubjectsSubjects(version: 901)
Course, academic year 2022/2023
  
Organic Chemistry of Biological Processes - MC270P99
Title: Organická chemie biologických procesů
Guaranteed by: Department of Organic Chemistry (31-270)
Faculty: Faculty of Science
Actual: from 2020
Semester: summer
E-Credits: 3
Examination process: summer s.:
Hours per week, examination: summer s.:2/1 Ex [hours/week]
Capacity: unlimited
Min. number of students: 3
Virtual mobility / capacity: no
State of the course: taught
Language: English
Level: specialized
Note: enabled for web enrollment
Guarantor: RNDr. Jiří Míšek, Ph.D.
Incompatibility : MC270P87
Opinion survey results   Examination dates   Schedule   
Annotation -
Last update: PharmDr. Eliška Matoušová, Ph.D. (07.06.2018)
The course will deal with chemical reactions proceeding in the living matter as a parallel to the reactions known from the organic chemistry laboratory. The following topics will be covered:
(1) Enzyme-catalyzed nucleophilic substitution, electrophilic addition, Michael addition, elimination, aldol reaction, Claisen condensations, amination-deamination, molecular rearrangements, and domino reactions, etc.
(2) Stereochemistry of the individual processes and isotopic labelling as a tool for elucidation of reaction mechanisms.
(3) The role of selected biomolecules in living organisms
(4) Biosynthesis of selected biomolecules and the methods for its artificial control with a view of development of new medicinal drugs.
(5) Mechanism of action of selected medicinal drugs and poisons (e.g., novichok) at a molecular level and the application of this knowledge for the development of new drugs.

Knowledge of standard organic chemistry and good arrow-pushing skills are a prerequisite. Passing a basic biochemistry course before attending this course is not required but would desirable.

Complete course materials will be handed out as a supplement to the lectures and tutorials.
Literature -
Last update: PharmDr. Eliška Matoušová, Ph.D. (07.06.2018)

Basic literature:

J. E. McMurry, T. Begley: The Organic Chemistry of Biological Pathways, 2nd edition, Roberts & Co Publishers, Greenwood Village, Colorado, 2016 (ISBN 9781936221561)

Recommended literature:

D. Van Vranken, G. A. Weiss: Introduction to Bioorganic Chemistry and Chemical Biology, Garland Science, 2012,   (ISBN 9780815342144)

Entry requirements - Czech
Last update: RNDr. Jana Rubešová, Ph.D. (01.04.2018)

Znalost organické chemie a biochemie v rozsahu přednášek chemických bakalářských oborů.

 
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