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Basic information: what is organic compound, isomers (constitutional, geometrical, stereoisomers, conformations), chemical bonding (single, double, triple bond, polarity, aromaticity), classification of organic compounds (hydrocarbons, derivatives - functional groups), chemical nomencalture. Overview of organic compounds: alkanes, alkenes, alkynes, arenes, halides, nitro compound, amines, alcohols, phenols, ehters, carbonyl compounds, carboxylic acids and their derivatives. Mechanisms of selected reaction types. Naturally occuring compounds. Last update: SMRCEK (27.09.2002)
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J. Svoboda: Organická chemie I.; VŠCHT Praha; http://vydavatelstvi.vscht.cz/katalog/uid_isbn-978-80-7080-561-9/anotace/ J. McMurry: Organická chemie, VŠCHT Praha; http://vydavatelstvi.vscht.cz/katalog/uid_isbn-978-80-7080-637-1/anotace/ Trnka T., Klinotová E., Kotora M., Sejbal J. Organická chemie pro posluchače nechemických oborů, PřF UK Praha 2002 Last update: Machara Aleš, Ing., Ph.D. (03.05.2012)
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Zkouška písemná - >50% (orientační hodnocení: 50-65 dobře, 65-79 velmi dobře, >80 následuje ústní zkouška). Pro stupeň výborně je třeba úspěšně zvládnout ústní část. Last update: Machara Aleš, Ing., Ph.D. (03.05.2012)
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Introduction What is organic chemistry about Organic chemistry and nature Organic chemistry in everyday life
Chemical Bond How are electrons arranged in atoms and hybridization Covalnt bond ovalentní vazba Inductive effect, resonance Isomerism
Alkanes and cycloalkanes Nomenclature of alkanes Reactions of alkanes Isomerism a conformation
Alkenes and alkyesy Addition reactions Markovnikov´s rule 1,4-Addition
Stereochemistry Chirality, elements of symmetry Enantiomers, biological properties
Aromatic compounds Definition of aromaticity Electrofilic aromatic substitution Directing groups Polycyclic aromatic compounds
Organic halogen compounds Synthesis of organic halides SN1 and SN2 substitutions E1 and E2 mechanisms
Alkohols a fenols Properties of alcohols (hydrogen bonding, acidity, bazicity, nucleophilicity) Reactions of alcohols
Thiols, ethers a thioethers
Aldehydes, ketones Carbonyl group Synthesis of alcohols and ketones Nucleophilic addition to C=O (alcohols, Grignard reagents, hydrides, cyanides) Keto-enol tautomerism Enolates, their application in synthesis (aldol condenzation, malonesterreactions) Quinones
Carboxylic acids Acidity (pKA), resonance structures of carboxylic anion
Synthesis of carboxylic acids Esterification and esters, amides, nitriles, acylhalides Thioesters
Amines Synthesis of amines Bazicity, hydrogen bonding Reaction with acids, quaternization Reaction with nitrous acid Diazocoupling Heterocyclic amines
Carbohydrates Fischer and Haworth formulas, conformation formulas Oxidation, reduction Acylation, etherification Oligosacharides, polysacharides
Aminoacids and peptides Peptide bond Peptide synthesis
Natural compounds
Last update: SMRCEK (20.01.2003)
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