SubjectsSubjects(version: 901)
Course, academic year 2022/2023
Modern methods in organic synthesis - Organocatalysis - MC270P103
Title: Moderní metody v organické syntéze - Organokatalýza
Czech title: Moderní metody v organické syntéze - Organokatalýza
Guaranteed by: Department of Organic Chemistry (31-270)
Faculty: Faculty of Science
Actual: from 2021
Semester: summer
E-Credits: 3
Examination process: summer s.:
Hours per week, examination: summer s.:2/1 Ex [hours/week]
Capacity: unlimited
Min. number of students: unlimited
Virtual mobility / capacity: no
State of the course: taught
Language: English
Note: enabled for web enrollment
Guarantor: doc. RNDr. Jan Veselý, Ph.D.
Incompatibility : MC270P84
Opinion survey results   Examination dates   Schedule   
Annotation -
Last update: PharmDr. Eliška Matoušová, Ph.D. (28.05.2019)
The course is focused on the application of small organic molecules as chiral catalysts for significant synthetic reactions and is complemented by a number of practical examples taken from the recent literature. Independent solving of synthetic problems by the students, based on the theoretical knowledge and skills acquired in this course, followed by lector’s critical comments and group discussions will be an integral part of the course.

Complete course materials will be handed out as a supplement to the lectures and tutorials.
Literature -
Last update: PharmDr. Eliška Matoušová, Ph.D. (28.05.2019)

Peter I. Dalko (Editor): Comprehensive Enantioselective Organocatalysis, Vol 1-3, Wiley-VCH, 2013. ISBN 978-3-527-33236-6.

Ramon Rios Torres (Editor): Stereoselective Organocatalysis, Wiley, 2013. ISBN 978-1-118-20353-8

Requirements to the exam - Czech
Last update: PharmDr. Eliška Matoušová, Ph.D. (28.05.2019)

Zkouška je písemná.

Syllabus - Czech
Last update: PharmDr. Eliška Matoušová, Ph.D. (26.06.2019)

1. Katalýza zahrnující enaminy jako intermediáty: Aldolova reakce, Mannichova reakce, alfa-funcionalizace karbonylových sloučenin, Michaelova adice.


2. Katalýza zahrnující iminiové ionty jako intermediáty: Cykloadice, Michaelova adice (adice na enony, epoxidace, Friede-Craftsova reakce, transferová hydrogenace, multikomponentní "domino" reakce).


3. Reakce s účastí vodíkových můstků a katalyzované Brønstedovými kyselinami: Michaelova adice, hydrokyanace, Mannichova reakce, aza-Henryho reakce, aza-Friedel-Craftsova reakce, Pictet-Spenglerova reakce, transferová hydrogenace, Morita-Baylis-Hillmanova reakce, Diels-Alderova reakce.


4. Katalýza Lewisovými bázemi: Allylace aldehydů, reakce aldolového typu, hydrokyanace, hydrosilylace.


5. Katalytická epoxidace


6. Katalýza karbeny


7. Katalyzátory fázového přenosu


8. Katalytická acylace

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