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Physical Organic Chemistry I - MC270P03

Title:	Fyzikální organická chemie I
Czech title:	Fyzikální organická chemie I
Guaranteed by:	Department of Organic Chemistry (31-270)
Faculty:	Faculty of Science
Actual:	from 2019
Semester:	winter
E-Credits:	3
Examination process:	winter s.:
Hours per week, examination:	winter s.:2/0, Ex [HT]
Capacity:	unlimited
Min. number of students:	3
4EU+:	no
Virtual mobility / capacity:	no
State of the course:	cancelled
Language:	Czech
Note:	enabled for web enrollment

Guarantor:	prof. Mgr. Jana Roithová, Ph.D.
Is incompatible with:	MC270P95
Is pre-requisite for:	MC270P79

Opinion survey results Examination dates Schedule

Annotation -

Last update: SMRCEK (27.09.2002)

A basic goal of the course is to encourage students to acquire basic knowledge of organic reaction mechanisms. The attention is focused on the most important processes used in modern organic synthesis emphasizing the principles of electron flow and MO theory, the role of organic reaction intermediates, and the control over chemo-, regio-, and stereoselectivity. The course includes selected mechanistic aspects of organometallic chemistry, supramolecular chemistry, and biochemistry.

Literature -

Last update: RNDr. Mgr. Jiří Kroutil, Ph.D. (09.10.2009)

Recommended literature:

T.H. Lowry, K.S. Richardson: Mechanism and theory in organic chemistry, 3rd edition, Harper Collins Publishers, 1987

E.V. Anslyn, D.A. Dougherty: Modern Physical Organic Chemistry, University Science Books 2006

E. Ruff, I.G. Csizmadia: Organic Reactions. Equilibria, kinetics and mechanism, Elsevier 1994.

L. Treindl: Chemická kinetika. SPN 1990.

O. Exner: Korelační vztahy v organické chemii SNTL 1981. ?exists also in English translation

Requirements to the exam - Czech

Last update: doc. Ing. Stanislav Smrček, CSc. (10.05.2012)

Ústní zkouška v rozsahu přednášené látky.

Syllabus -

Last update: RNDr. Mgr. Jiří Kroutil, Ph.D. (09.10.2009)

Qualitative theory of chemical reactivity

Basic concepts of chemical kinetics

Quantitative theory of chemical reactivity

Eyring theory of absolute reaction rates

Kinetic isotopic effects

Basic concepts of qualitative theory of chemical reactivity

Potential energy hypersurface

Reaction coordinate

Hard and soft acids and bases

Bell-Evans-Polanyi principle

Kinetic and thermodynamic control of reactivity

Curtin-Hammett principle

Empirical structure-reactivity relationships

Hammett equation

Taft equation Brönsted equation

Reactivy-selectivity relationships

Statistical treatment of parameters of correlation equations

Theory of pericyclic reactions

Classification of pericyclic reactions

Electrocyclic reactions

Cycloaddition reactions

Sigmatropic reactions

1,3-dipolar addition

Other types of pericycli reactions

Woodward-Hoffmann rules

Inversion of Woodward-Hoffmann rules with excitation

Woodward-Hoffmann rules and symmetry

Theory of frontier orbitals

Regioselectivity in pericycli reactions

Effect of reaction conditions and reaction media on reactivity

Influence of temperature and pressure

Solvent effect

Ionic liquids

Effect of chiral media on reactivity

Sonochemistry ?effect of ultrasound

Microwave activation of chemical reactions

Effect of IR laser radiation

Effect of visible and UV radiation ? photochemistry

Basic photophysical and photochemical processes

Effect of catalysis on reactivity

Homogeneous catalysis

Acido-basic catalysis

Catalysis by Lewis acids and bases

Catalysis of pericyclic reactions

Phase transfer catalysis

Methods of the study of mechanism of chemical reactions