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Course, academic year 2023/2024
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Chemical transformations - MC260P145
Title: Chemical transformations
Guaranteed by: Department of Physical and Macromolecular Chemistry (31-260)
Faculty: Faculty of Science
Actual: from 2023
Semester: summer
E-Credits: 5
Examination process: summer s.:
Hours per week, examination: summer s.:2/2, C+Ex [HT]
Capacity: unlimited
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
State of the course: taught
Language: English
Note: enabled for web enrollment
Guarantor: RNDr. Ondřej Sedláček, Ph.D.
Teacher(s): Ing. Ondřej Baszczyňski, Ph.D.
RNDr. Ondřej Sedláček, Ph.D.
Annotation
The course Chemical transformations provides an introduction to the general principles of chemical reactivity in
the context of modern multidisciplinary science. After the general introduction, the students will get familiar with the
basic concepts of inorganic, organic, organometallic, and polymer chemistry on the basis of general reactivity
concepts rather than memorizing particular reactions. Finally, one lecture will be devoted to the chemical
understanding of natural processes, providing an essential introduction to biochemistry and molecular biology.
Overall, the course will focus on overlaps within different areas of chemistry and between chemistry and other
natural sciences, particularly physics and biological sciences.
The course is supplemented by a practical workshop.
Last update: Ušelová Kateřina, RNDr., Ph.D. (31.01.2022)
Literature
  • Keeler J. and Wothers P.: Why chemical reactions happen, Oxford, 2003, ISBN 0199249733
  • Keeler J. and Wothers P.: Chemical structure and reactivity: an integrated approach, Oxford, 2013, ISBN 9780199604135
  • McMurry J.: Organic chemistry, Cengage Learning, 2015, ISBN 305080483
  • Housecroft, C. E. and Sharp, A. E.: Inorganic Chemistry, 5th Edition, Pearson, 2018, ISBN 1292134143
  • Stevens, M.P.: Polymer Chemistry: An Introduction, 3rd Edition, Oxford University Press, 1998, ISBN 0195124448

Last update: Ušelová Kateřina, RNDr., Ph.D. (31.01.2022)
Requirements to the exam
  • For each lecture, the students will be provided with study materials to be reviewed before the particular lecture/workshop.
  • The final mark is based on the oral examination (80%) and the results of tests during the course (20%). The oral examination takes place during the examination period, and students must first obtain credit for the workshop. The credit for the workshop is based on two tests (midterm and final, each 50%).

Last update: Ušelová Kateřina, RNDr., Ph.D. (31.01.2022)
Syllabus

Lecture 1: Introduction to Chemical Reactivity, Redox reactions

  • Overview of chemical reactivity principles, transition from chemical principles to chemical transformations, redox reactions (oxidations, reductions), electron transfer, reaction mechanisms, energy production, environmental impact

Lecture 2: Fundamentals of Organic Reaction Mechanisms

  • Basics of organic reaction mechanisms, types of reactions: substitution, addition, elimination, electron movement in reactions, curved arrows, induction effect, mesomeric effect, dipole moment, polarity, acids-base reactions

Lecture 3: Stereochemistry and Chirality in Organic Reactions

  • Understanding stereochemistry, E/Z isomerism, absolute configuration (Cahn-Ingold-Prelog system), chirality in biological systems, amino acids, influence on drug design and pharmacology (atropoisomers)

Lecture 4: Substitution and Elimination reactions

  • Preparation, reactions, organometallic compounds, nucleophilic substitution Sn1/Sn2, elimination E1/E2/E1cb, halogenoalkanes, alcohols, ethers, thiols, amines

Lecture 5: Electrophilic Aromatic Substitutions

  • Aromaticity, halogenation, nitration, sulfonation, Friedel-Crafts reactions, substitution effects, diazotization, Sandmeyer reactions, special case: Nucleophilic aromatic substitution

Lecture 6: Chemistry of Carbonyl Compounds

  • Reactivity of carbonyl group, reactions at α-position, carboxylic acids, functional derivatives of carboxylic acids, keto-enol tautomerism, aldolization, Claisen condensation, peptide bond,

Lecture 7: Catalysis

  • Theory of catalysis, types of catalysis: heterogeneous, homogeneous, enzymatic, catalytic mechanisms, industrial, environmental applications, nanocatalysts, biocatalysts research

Lecture 8: Industrially relevant chemical processes

  • Sources of chemicals, valorization of fossil resources, mineral resources and biomass, industrial chemistry principles, Haber-Bosch process, contact process, green chemistry, sustainability

Lecture 9: Biomedical Chemistry: Drug Design, Drug delivery, Bioconjugations

  • Chemical basis of drug action, principles of drug design and development, case studies of drug discovery

Lecture 10: Introduction to Material Chemistry

  • Basics of material chemistry, polymer chemistry, chemical principles in new material development, nanomaterials and their applications

Lecture 11: Supramolecular Chemistry and Chemical Biology

  • Principles of supramolecular chemistry, molecular recognition and self-assembly, applications in chemical biology and nanotechnology

Lecture 12: Biomaterials

  • Biomaterials: classification, properties, biocompatibility, bioactivity, tissue engineering, medical implants, drug delivery systems, ethical, regulatory aspects in biomaterials
Last update: Sedláček Ondřej, RNDr., Ph.D. (02.02.2024)
 
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