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Last update: RNDr. Jiří Liberda, Ph.D. (16.12.2009)
Lectures - in Czech - |
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Last update: prof. RNDr. Jan Konvalinka, CSc. (06.11.2011)
Literatura: Handbook of proteolytic enzymes (A.J. Barett, N. D. Rawlings and F.J. Woessner, eds.) Academic Press, New York, 1998
aktuální přehledné časopisecké články budou doporučovány nebo v elektronické formě předávány studentům během přednášek |
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Last update: prof. RNDr. Jan Konvalinka, CSc. (06.11.2011)
Zkouška se koná ústní formou, student si vylosuje 3 otázky z různých témat podle syllabu z důrazem na onjasnění regulační role proteolysy. |
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Last update: SIMONAT (29.04.2002)
Mechanism of proteolysis. Classes and families of proteases. Non-specific degradation of proteins: N-end rule, ubiquitin pathway, proteasomes and antigen presentation by MHC I molecules. Lysosomes, cathepsins B,H, D, S and L and their inhibitors. Lysosomal degradation and the MHC II system. Cathepsins in inflammation; muscular dystrophy; tumors and metastasis. Proteases in cellular regulation: caspases and apoptosis, cyclins, their degradation and the regulation of the cell cycle. Interleukin and ICE. Prohormones and proenzymes, signal peptidases and intercellular targetting. Proteases in homeostasis: renin-angiotensin system., blood coagulation cascade. Proteases of human pathogens: processing of viral polyproteins in picornaviruses, flaviviruses and retroviruses. Specificity, activity and inhibition of the HIV protease. Proteases of human parasites and their inhibitors: plasmepsins, proteinases from Schistosoma and Trypanosoma. Endogenous proteinase inhibitors as regulators of proteolysis. 3-D structure of proteases and their inhibitors; rational, structure-assisted drug design, combinatorial chemistry, examples of protease inhibitors as succesful drugs.
References: Handbook of proteolytic enzymes (A.J. Barett, N. D. Rawlings and F.J. Woessner, eds.) Academic Press, New York, 1998 |