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Course, academic year 2022/2023
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Molecular biology and genetics I - MC250P15
Title: Molekulární biologie a genetika I
Czech title: Molekulární biologie a genetika I
Guaranteed by: Department of Biochemistry (31-250)
Faculty: Faculty of Science
Actual: from 2019
Semester: winter
E-Credits: 3
Examination process: winter s.:combined
Hours per week, examination: winter s.:2/0, Ex [HT]
Capacity: unlimited
Min. number of students: unlimited
Virtual mobility / capacity: no
State of the course: taught
Language: Czech
Note: enabled for web enrollment
Guarantor: RNDr. Petr Novák, Ph.D.
Teacher(s): RNDr. Petr Novák, Ph.D.
Annotation -
Last update: RNDr. Petr Novák, Ph.D. (11.10.2020)
!!! N.B. LECTURES ARE DELIVERED IN CZECH LANGUAGE. EXAMINATION POSSIBLE IN CZECH OR ENGLISH. Basic course of molecular biology deals primarily with two most important classes of biological macromolecules - nucleic acids and proteins. Static aspects involve discussion of the structure of macromolecules and their complexes (DNA binding proteins, protein complexes, molecular motors). Dynamic aspects include classical chapters on DNA replication, transcription, translation, folding and posttranslational modifications of proteins, and their cellular transport. Molecular mechanisms underlying selected cellular processes such as regulation of the cell cycle, apoptosis, membrane transport, cellular signaling and integration of cells into tissues and organs are also covered.
Lectures - in Czech -

Webinar at
Literature -
Last update: RNDr. Petr Novák, Ph.D. (11.10.2020)

Molecular Cell Biology, 7th Edition by Harvey Lodish, Arnold Berk, Paul Matsudaira, Chris A. Kaiser, Monty Krieger, Matthew P. Scott, Lawrence Zipursky, and James Darnell. Resources are organized by chapter of the textbook and by content type. To access resources, please select a chapter or category below. Web page *******************

Requirements to the exam - Czech
Last update: NOVAK4/NATUR.CUNI.CZ (31.10.2011)

Písemná část zkoušky se skládá z deseti otázek. Každá je za dva body. K ústní části zkoušky jsou připuštěni jen studenti, kteří z písemnné části získali dvanáct (60%) a více bodů.

Syllabus -
Last update: SIMONAT (08.04.2002)

Definition of molecular biology. History of molecular biology. Structure and function of nucleic acids. Molecular structure of genes and chromosomes. Protein structure and function. Protein complexes, self-assembly. Molecular motors. DNA replication, recombination and repair. Regulation of cell cycle. Apoptosis. Transcription in prokaryotes and eukaryotes. Regulation of transcription. Translation. Structure of the ribosome. Protein channel. Insertion of proteins into plasmatic membranes. Intracellular transport, folding and posttranslational modifications of proteins. Membrane transport. Most important cellular signaling cascades. Gene control in development. Hox genes in Drosophila and other organisms. Integration of cells into tissues. Cell adhesion molecules.

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