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Last update: prof. RNDr. Jiří Hudeček, CSc. (19.01.2018)
Lectures - in Czech and/or in English (in case of more than 2 interested students; otherwise the English course takes the form of a "directed reading"). |
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Last update: prof. RNDr. Jiří Hudeček, CSc. (16.02.2020)
Berg., J.M., Tymoczko J.L, Stryer L.: Biochemistry. 6th edition, WH Freeman and Co., N. York 2007 Bertini L, Gray HB, Lippard SJ, Valentine JS: Bioinorganic chemistry. University Science Books, Sausalito 1994. Adv. Inorg. Chem Vol. 51 (2001) (Sykes, AG, Mauk G., eds) Academic Press Roat-Malone R.M. Bioinorganic Chemistry, A Short Course, 2nd Ed. , Wiley 2007. Ghosh A. (ed.) The Smallest Biomolecules. Diatomics and Their Interactions with Heme Proteins. Elsevier 2008. Ochiai N.: Bioinorganic Chemistry. A Survey. Academic Prass 2008. Crichton R. R.: Biological Inorganic Chemistry. An Introduction. Elsevier 2008. D. Rehder: Bioinorganic Chemistry. Oxford University Press 2014.
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Last update: prof. RNDr. Jiří Hudeček, CSc. (04.11.2011)
Oral examination, contents see syllabus. |
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Last update: SIMONAT (30.04.2002)
1. Porphyrins and metalloporphyrins - nomenclaure, natural abundance, physico-chemical properties, spectroscopy and structure. Analogues and its use in therapy.
2. Hemeproteins - functional classification, common physico-chemical and structural properties.
3. Oxygen carriers and similar binding proteins. Myoglobin (characteristics, functional role of protein chain). Hemoglobin - differences and similaritites to myoglobin. Allostery - phenomenological description and theoretical models, effectors and modulators. Ontogenetic and phylogenetic aspects - fetal hemoglobin, molecular pathology (hemoglobinopathies, anemia, thallassemias) non-mammalian hemoglobins, leghemoglobin. Non-heme oxygen carriers (hemerythrin, hemocyanin). NO carriers - nitrophorin.
4. Electron transfer. Cytochromes, cytochrome c (description, functional and phylogenetic aspects). Electron transfer chains (respiratory chain, electron transfer in photosynthesis). Other cytochromes and flavocytochromes. FeS proteins.
5. Heme enzymes, oxygen activation. Cytochromes P450, NO synthase. Oxidases, oxygenases. Peroxidases, catalase, superoxidismutases.
6. Heme sensors - sGC, FixL, CooA.
7. Metobolism of heme and iron. Porphyrias, jaundice. Ferritin, transferrin.
8. Porphyrin analogues as coenzymes. Chlorophyll, photosynthetic reaction centers, Phytochrome, open chain tetrapyrroles, phycobillin.
9. General introduction to biochemical importance of metals, detoxication, metallothioneins.
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