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Last update: prof. RNDr. Jiří Hudeček, CSc. (04.01.2010)
Lectures - in Czech - |
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Last update: prof. RNDr. Jiří Hudeček, CSc. (04.01.2010)
Branden C, Tooze J.: Introduction to Protein Structure, Garland, N. York 1991. Berg JM, Tymoczko JL, Stryer L.: Biochemistry, 6th Ed., WH Freeman, N York 2007. |
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Last update: prof. RNDr. Jiří Hudeček, CSc. (04.01.2010)
Oral exam, based on the syllabus. |
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Last update: SIMONAT (30.04.2002)
1. Peptides and globular proteins. Basic structural concepts, physico-chemical characteristics. Description of structure - internal coordinates, diedral angles, Ramachandran plot. Structural hierarchy, primary, secondary, tertiary and quarternary structure in classical sense and as defined in IUB/IUPAC recommendations. Supersecondary structure, structural motifs, domains. Structural classification. Prediction and modelling of stucture. Structural comparisons. Protein folding and dynamics, denaturation. Thermostable proteins, integral membrane proteins.
2. Nucleic acids. Basic description, internal coordinates, approximate structural description. RNA, DNA structural types. Description of double helices, base pairing. Z-DNA and triple helix.
3. Polysaccharides. Basic description. Structural types - starch, cellulose, pectin, heparin.
4. Supportive and structural elements. General principles of their structure Fibrous proteins - fibrin, collagenes, keratins, fibroins.Proteoglycans. Lignin..
5. Conversion of chemical energy to movement. Muscle proteins. Cillia and flagella.
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