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Course, academic year 2022/2023
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Coordination and Supramolecular Chemistry - MC240P48
Title: Koordinační a supramolekulární chemie
Czech title: Koordinační a supramolekulární chemie
Guaranteed by: Department of Inorganic Chemistry (31-240)
Faculty: Faculty of Science
Actual: from 2018
Semester: winter
E-Credits: 3
Examination process: winter s.:
Hours per week, examination: winter s.:2/0, Ex [HT]
Capacity: unlimited
Min. number of students: unlimited
Virtual mobility / capacity: no
State of the course: taught
Language: Czech
Explanation: Přednáška určena především pro posluchače KATA
Additional information: http://dl2.cuni.cz/course/view.php?id=1248
Note: enabled for web enrollment
Guarantor: prof. RNDr. Jiří Mosinger, Ph.D.
Teacher(s): prof. RNDr. Jan Kotek, Ph.D.
prof. RNDr. Jiří Mosinger, Ph.D.
Annotation -
Last update: prof. RNDr. Jiří Mosinger, Ph.D. (24.10.2019)
Introduction to coordination chemistry and definition of concepts, e.g. coordination number, chelation effect, donor atom. Ligand classification. Chemical bond in coordination compounds (ligand field theory) and explanation of some properties of complexes (spectral, magnetic, redox behavior). Chemical behavior of complexes, thermodynamic stability and kinetically labile and inert complexes. Examples of different kinds of coordination compounds and their utilization in practice (catalysis, analytical chemistry). Bioinorganic chemistry and metal complexes in medicine.
Introduction to supramolecular chemistry. Classification of supramolecular "host–guest" (receptor–substrate) compounds. Thermodynamic and kinetic selectivity. Nature of supramolecular interactions (ion–ion, ion–dipole, dipole–dipole, Hydrogen bonding, Cation-π interaction, "π-π stacking", Van der Waals forces, Hydrophobic effects). Supramolecular chemistry of life. Application in medicine.
Literature -
Last update: doc. RNDr. Vojtěch Kubíček, Ph.D. (26.10.2019)
  • LUKEŠ I.; MIČKA Z.: Anorganická chemie II.díl (Systematická část). Praha: UK-Karolinum 1999.
  • LIPPARD J., BERG J.M.: Principles of Bioinorganic Chemistry, University Science Books, 1994.
  • STEED J.W., ATWOOD J.L.: Supramolecular Chemistry, John Wiley&Sons, New York 2000.
Requirements to the exam -
Last update: doc. RNDr. Vojtěch Kubíček, Ph.D. (26.10.2019)

Combined exam - written and oral parts.

Syllabus -
Last update: doc. RNDr. Vojtěch Kubíček, Ph.D. (12.10.2013)
1. Introduction to coordination chemistry

1.1. Coordination compounds, basic concepts
1.2. Coordination number, stereochemistry of complexes, chelates
1.3. Donor atoms and kinds of ligands

2. Bonding in coordination compounds

2.1. Transition and inner transition metals (lanthanoids)
2.2. Chemical bond in coordination compounds

2.2.1. Crystal and ligand field theory
2.2.2. Ligand spectrochemical series
2.2.3. Stable electronic configurations

2.3. Absorption electronic spectra of complexes
2.4. Magnetic properties of complexes
2.5. Redox properties of complexes

3. Properties of coordination compounds

3.1. Stability constants
3.2. Kinetic behavior of complexes
3.3. Reactivity of coordination compounds

4. Kinds of coordination compounds and their importance

4.1. Aquacomplexes, ammincomplexes
4.2. Organometallic compounds
4.3. Homogeneous catalysis, examples of catalytic cycles
4.4. Complexes in analytical chemistry
4.5. Principles of bioinorganic chemistry

4.5.1. Role of metal ions in living systems, metalloenzymes
4.5.2. Metal metabolism
4.5.3. Oxygen and metal ion transports
4.5.4. Electron transfer in proteins
4.5.5. Utilization of metal in human medicine (cancerostatics and contrast agents)

5. Introduction to supramolecular chemistry

5.1. Classification of supramolecular "host–guest" (receptor–substrate) compounds
5.2. Thermodynamic and kinetic selectivity
5.3. Nature of supramolecular interactions (ion–ion, ion–dipole, dipole–dipole, Hydrogen bonding, Cation–π interaction, "π-π stacking", Van der Waals forces, Hydrophobic effects)
5.4. Supramolecular chemistry of life
5.5. Application in medicine


 
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