SubjectsSubjects(version: 901)
Course, academic year 2022/2023
  
Bioinorganic Chemistry - MC240P31
Title: Bioanorganická chemie
Czech title: Bioanorganická chemie
Guaranteed by: Department of Inorganic Chemistry (31-240)
Faculty: Faculty of Science
Actual: from 2020
Semester: summer
E-Credits: 3
Examination process: summer s.:
Hours per week, examination: summer s.:2/0 Ex [hours/week]
Capacity: unlimited
Min. number of students: unlimited
Virtual mobility / capacity: no
State of the course: taught
Language: Czech, English
Additional information: http://dl2.cuni.cz/course/view.php?id=1241
Note: enabled for web enrollment
Guarantor: doc. RNDr. Vojtěch Kubíček, Ph.D.
Annotation -
Last update: doc. RNDr. Vojtěch Kubíček, Ph.D. (30.01.2020)
Fundamentals of inorganic solution chemistry. Transport and storage of metals ions in vivo. Metalloproteins and metalloenzymes - oxygen carriers, hydrolases, redox chemistry. Alkali and alkaline earth metals. Metals in the regulation of biochemical events. Cell toxicity and chemoterapeutics. Metal complexes in medical imaging methods and radiotherapy.
The course is designed for Master and PhD students.
Literature -
Last update: doc. RNDr. Vojtěch Kubíček, Ph.D. (25.02.2021)
Requirements to the exam -
Last update: doc. RNDr. Vojtěch Kubíček, Ph.D. (26.10.2019)

Presentation of the selected topic and oral exam.

Syllabus -
Last update: doc. RNDr. Vojtěch Kubíček, Ph.D. (30.01.2020)

1) Fundamentals of Inorganic Solution Chemistry
Formal oxidation states and coordination geometries biologically important metal ions
Stability constants, stabilization of oxidation states, kinetics and mechanizm of reactions involving metal complexes. Electron transfer reactions.

2) Transport and storage
Metal ion uptake and transmembrane ion transport. Transport and storage of metals ions in vivo.

3) Oxygen Carriers
Myoglobin and hemoglobin. Hemerythrin, hemocyanin.

4) Hydrolases
Hydrolase enzymes, carboxypeptidase A, phosphatases, hydro-lyasa enzymes – acotinase.

5) Metalloproteins and Metalloenzymes – Redox Chemistry
Cofactors and coenzymes in metaloredox proteins. Iron-sulfur clusters, hemes, copper ion and its complexes, molybdenum, cobaltamins, nickel coenzymes. Mitochondrial electron transport.

6) Alkali and Alkaline Earth Metals.
Overview of biological chemistry of group I and II. Enzyme activation, complexes with nucleic acids, biominerales, skeletal mass.

7) Toxicity and Chemoterapeutics.
Oxygen toxicity, peroxidase, metal toxicity. Coordination complexes as therapeutic agents.

8) Metal complexes in medical imaging techniques and radiotherapy.
Magnetic resonance imaging, radiodiagnostics, radiotherapy, production and application of metal radioisotopes.




References: Cowan J.A., Inorganic Biochemistry, VCH Publishers 1993, Lippard S.J. ed, Progress in Inorganic Chemistry: Bioinorganic Chemistry, 38, 1990.

Entry requirements -
Last update: doc. RNDr. Vojtěch Kubíček, Ph.D. (29.03.2018)

The course is designed for master students. Knowledges of Inorganic chemistry and Biochemistry are required!

 
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