2024-11-06, 13:30-15:30
Lecture I
2024-11-13, 13:30-15:30
Lecture II
2024-11-20, 13:30-15:30
Lecture III
2024-11-27, 13:30-15:30
Lecture IV
2024-12-04, 13:30-15:30
Lecture V
Career planning requires at least some basic knowledge on the different fields available to the students. For students of biology, biochemistry and medicine the field of biomedical research offers many interesting opportunities. At the same time, this field is often underrepresented in biological courses. The course "Biomedical Research" therefore will highlight the relevance of the field by presenting exemplary research projects on cancer research, diabetes and other human diseases with high socio-economic impact. As part of this, the course will introduce key technologies employed in biomedical research, such as next-generation sequencing and functional genomics. At the same time, the course "Biomedical Research" will give students an insight into potential job opportunities, career paths and funding options. It is not unlikely, that a substantial proportion of biology students will decide for a career in biomedical research, which offers interesting salaries and funding options on an international scale.
The course is suitable for bachelor students, master students and PhD students. Knowledge on the basic terminology in molecular biology is required to understand the course content. To complete the course successfully, students will have to pass a multiple choice based exam at the end of the course.
Aim of the course: After participating in the course "biomedical research" the student will be able to:
1) outline the major fields in biomedical research
2) summarize principles of disease biology
3) describe the technologies employed in biomedical research
4) list fundamental principles of translational research
5) critically assess how realistic specific project goals are in biomedical research
6) connect their own skills and interests with biomedical research fields in order to shape their career
Last update: Šebková Nataša, RNDr., Ph.D. (27.09.2024)
2024-11-06, 13:30-15:30
Přednáška I
13. 11. 2024, 13:30-15:30
Přednáška II
20. 11. 2024, 13:30-15:30
Přednáška III
27. 11. 2024, 13:30-15:30
Přednáška IV
4. 12. 2024, 13:30-15:30
Přednáška V
Plánování kariéry vyžaduje alespoň některé základní znalosti o různých oborech dostupných studentům. Pro studenty biologie, biochemie a medicíny nabízí obor biomedicínského výzkumu mnoho zajímavých příležitostí. Současně je toto pole v biologických kurzech často nedostatečně zastoupeno. Kurz „Biomedicínský výzkum“ proto zdůrazní význam oboru prezentací příkladných výzkumných projektů v oblasti výzkumu rakoviny, cukrovky a dalších lidských chorob s vysokým socioekonomickým dopadem. Součástí tohoto kurzu bude představení klíčových technologií používaných v biomedicínském výzkumu, jako je sekvenování nové generace a funkční genomika. Kurz „Biomedicínský výzkum“ zároveň umožní studentům nahlédnout do možných pracovních příležitostí, profesních cest a možností financování. Není pravděpodobné, že podstatná část studentů biologie se rozhodne pro kariéru v biomedicínském výzkumu, který nabízí zajímavé platy a možnosti financování v mezinárodním měřítku.
Kurz je vhodný pro studenty bakalářského, magisterského a doktorského studia. Pro porozumění obsahu předmětu je nutná znalost základní terminologie molekulární biologie. Pro úspěšné absolvování předmětu budou studenti na konci kurzu povinni složit zkoušku založenou na výběru z více možností.
Aim of the course: After participating in the course "biomedical research" the student will be able to:
1) outline the major fields in biomedical research
2) summarize principles of disease biology
3) describe the technologies employed in biomedical research
4) list fundamental principles of translational research
5) critically assess how realistic specific project goals are in biomedical research
6) connect their own skills and interests with biomedical research fields in order to shape their career
Last update: Šebková Nataša, RNDr., Ph.D. (27.09.2024)
Literature -
There is no reference textbook for lecture, however, there is a few recommendations for review articles covering parts of the contents: 1) Key Advances In Medicine - Translational and clinical medicine from Nature Reviews (2018) ebook compiled annually, nature.com 2) Research Strategies for Academic Medical Centers: A Framework for Advancements Toward Translational Excellence (2017) Haley R, Champagne TJ. Research Management Review, Volume 22 3) The Benefits of Medical Research and the Role of the NIH (2000) Mack C, United States Senate
Last update: Šebková Nataša, RNDr., Ph.D. (25.10.2019)
Neexistuje žádná referenční učebnice pro přednášku, existuje však několik doporučení k recenzním článkům týkajícím se částí obsahu: 1) Key Advances In Medicine - Translational and clinical medicine from Nature Reviews (2018) ebook compiled annually, nature.com 2) Research Strategies for Academic Medical Centers: A Framework for Advancements Toward Translational Excellence (2017) Haley R, Champagne TJ. Research Management Review, Volume 22 3) The Benefits of Medical Research and the Role of the NIH (2000) Mack C, United States Senate
Last update: Šebková Nataša, RNDr., Ph.D. (25.10.2019)
Requirements to the exam -
1) Knowledge: recall lecture contents. Level of detail: as trained in the tutorial 2) Transfer & understanding: transfer lecture contents into hypothetical scenarios 3) The exam will not cover module V: "Shaping your Career in Clinical Research" 4) In the multiple choice exam format, to pass the student needs to achieve at least 60% of the maximum points
Last update: Šebková Nataša, RNDr., Ph.D. (25.10.2019)
1) Znalosti: připomenout obsah přednášky. Úroveň podrobnosti: vyškolení v tutoriálu 2) Přenos a porozumění: přenos obsahu přednášky do hypotetických scénářů 3) Zkouška nezahrnuje modul V: „Formování kariéry v klinickém výzkumu“ 4) Ve formátu zkoušky s vícenásobným výběrem musí student dosáhnout alespoň 60% maximálních bodů
Last update: Šebková Nataša, RNDr., Ph.D. (25.10.2019)
Syllabus -
1. Biology of Diseases 1.1 introduction - why learning about clinical research, course outline & goals 1.2 disease biology exemplified in cardiovascular disease, diabetes, cancer and inflammatory bowel disease 1.3 understanding disease biology: cause vs. association, past vs. present incidence 2. Tools and Technologies in Clinical Research 2.1 old tools in old times - history of clinical research 2.2 toolbox I: classical approaches from stem cells to bacteria 2.3 toolbox II: novel approaches from genetics to genomics 3. Nuts and Bolts to connect Biology to Medicine 3.1 translational medicine - creating benefit for patients - employing your toolbox 3.2 implementing science in the clinic - current concepts and visions for the future 3.3 go big or go home - the necessity of international consortia in clinical research 4. Textbook Biology versus Clinical Research – how things look in the real world 4.1 can you cure a complex disease? - aiming for realistic goals 4.2 real life examples of research in complex diseases - goals vs. achievements 4.3 Recap of module I-IV & exam tutorial 5. Shaping your Career in Clinical Research 5.1 career cornerstones I: matching your skills and interests to research areas 5.2 career cornerstones II: grants, positions and your future in biomedicine
Last update: Šebková Nataša, RNDr., Ph.D. (29.11.2019)
1. Biology of Diseases 1.1 introduction - why learning about clinical research, course outline & goals 1.2 disease biology exemplified in cardiovascular disease, diabetes, cancer and inflammatory bowel disease 1.3 understanding disease biology: cause vs. association, past vs. present incidence 2. Tools and Technologies in Clinical Research 2.1 old tools in old times - history of clinical research 2.2 toolbox I: classical approaches from stem cells to bacteria 2.3 toolbox II: novel approaches from genetics to genomics 3. Nuts and Bolts to connect Biology to Medicine 3.1 translational medicine - creating benefit for patients - employing your toolbox 3.2 implementing science in the clinic - current concepts and visions for the future 3.3 go big or go home - the necessity of international consortia in clinical research 4. Textbook Biology versus Clinical Research – how things look in the real world 4.1 can you cure a complex disease? - aiming for realistic goals 4.2 real life examples of research in complex diseases - goals vs. achievements 4.3 Recap of module I-IV & exam tutorial 5. Shaping your Career in Clinical Research 5.1 career cornerstones I: matching your skills and interests to research areas 5.2 career cornerstones II: grants, positions and your future in biomedicine
Last update: Šebková Nataša, RNDr., Ph.D. (29.11.2019)
Learning outcomes -
Learning Outcomes for the Course “Biology of Diseases”
1. Introduction to Disease Biology
Defines the fundamental purpose and scope of clinical research.
Analyzes the interrelation between disease mechanisms and medical research goals.
Explains why studying disease biology is essential for translational medicine.
Describes the key objectives and structure of the course.
2. Understanding Major Human Diseases
Characterizes the biological basis of cardiovascular disease, diabetes, cancer, and inflammatory bowel disease.
Identifies shared and distinct molecular and cellular mechanisms among these diseases.
Distinguishes between cause and association in disease processes and epidemiological data.
Explains historical and current trends in disease incidence and their scientific implications.
3. Tools and Technologies in Clinical Research
Defines traditional and modern research methodologies from stem cell studies to genomic analysis.
Describes how classical and novel tools contribute to understanding disease mechanisms.
Analyzes how the evolution of research technologies has transformed biomedical discovery.
Characterizes the strengths and limitations of different experimental approaches.
4. Translational Medicine and Clinical Implementation
Identifies strategies for translating laboratory discoveries into clinical applications.
Explains the concept of translational medicine and its importance for patient benefit.
Analyzes challenges in implementing scientific findings into clinical practice.
Describes the role of international collaborations and consortia in advancing medical innovation.
5. Real-World Clinical Research
Distinguishes between textbook biology and real-life clinical research contexts.
Explains the complexity of curing multifactorial diseases and setting realistic research goals.
Analyzes real-world examples of success and limitations in complex disease research.
Describes lessons learned from past and ongoing studies in the field.
6. Career Development in Clinical Research
Defines key career pathways and professional opportunities in biomedical science.
Identifies personal strengths and interests relevant to specific research areas.
Describes the processes of obtaining grants, positions, and building a sustainable career.
Explains how scientific, ethical, and collaborative skills shape success in biomedicine.
Last update: Šebková Nataša, RNDr., Ph.D. (12.01.2026)
Learning Outcomes for the Course “Biology of Diseases”
1. Introduction to Disease Biology
Defines the fundamental purpose and scope of clinical research.
Analyzes the interrelation between disease mechanisms and medical research goals.
Explains why studying disease biology is essential for translational medicine.
Describes the key objectives and structure of the course.
2. Understanding Major Human Diseases
Characterizes the biological basis of cardiovascular disease, diabetes, cancer, and inflammatory bowel disease.
Identifies shared and distinct molecular and cellular mechanisms among these diseases.
Distinguishes between cause and association in disease processes and epidemiological data.
Explains historical and current trends in disease incidence and their scientific implications.
3. Tools and Technologies in Clinical Research
Defines traditional and modern research methodologies from stem cell studies to genomic analysis.
Describes how classical and novel tools contribute to understanding disease mechanisms.
Analyzes how the evolution of research technologies has transformed biomedical discovery.
Characterizes the strengths and limitations of different experimental approaches.
4. Translational Medicine and Clinical Implementation
Identifies strategies for translating laboratory discoveries into clinical applications.
Explains the concept of translational medicine and its importance for patient benefit.
Analyzes challenges in implementing scientific findings into clinical practice.
Describes the role of international collaborations and consortia in advancing medical innovation.
5. Real-World Clinical Research
Distinguishes between textbook biology and real-life clinical research contexts.
Explains the complexity of curing multifactorial diseases and setting realistic research goals.
Analyzes real-world examples of success and limitations in complex disease research.
Describes lessons learned from past and ongoing studies in the field.
6. Career Development in Clinical Research
Defines key career pathways and professional opportunities in biomedical science.
Identifies personal strengths and interests relevant to specific research areas.
Describes the processes of obtaining grants, positions, and building a sustainable career.
Explains how scientific, ethical, and collaborative skills shape success in biomedicine.
Last update: Šebková Nataša, RNDr., Ph.D. (12.01.2026)
