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The Immunology of infectious diseases course is intended for advanced MSc or PhD students with an interest in host-pathogen interactions. The course is held in English, the first half of each lecture is devoted to the theoretical background and during the second part, the emphasis is given to the interaction and discussion between lecturer and students focusing on a current research paper(s) essential for selected topics. Various aspects of host-pathogen interactions are going to be covered during the course, starting from differences between systemic and epithelial immune responses, further focusing on the complexity of immune response during viral, bacterial, fungal or parasitic infection and closing the circle with the escape strategies imposed by pathogens in order to prevent the immune response. The main objective of the course is to understand how the complexity of the immune response against pathogens is achieved and regulated. Students will also learn to critically read and discuss scientific papers in the quickly evolving field of host-pathogen interaction.
Last update: Dobeš Jan, doc. Mgr., Ph.D. (21.07.2022)
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Selected scientific papers are available for each lecture and there are going to be sent by the lecturer prior to the lecture. Students will be granted access to presentations used during lectures at the end of the course. The following book is also covering part(s) of the lecture: Immunology, Infection and Immunity - G.B. Pier, J. B. Lyczak and L. M. Wetzler. Last update: Dobeš Jan, doc. Mgr., Ph.D. (21.07.2022)
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Given the format of the course, active attendance on 80% of the lectures is required. The grade for the course will be based on one final take-home exam. There will be four questions for the final exam (maximum one page per answer). Exams will be handed out at the end of the final class and will be due during the next 48 hours. Answers for the take-home exams have to be done independently. Questions are going to be based on the topics covered during lectures. Last update: Dobeš Jan, doc. Mgr., Ph.D. (21.07.2022)
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1. Introduction, historical perspective of the fight against infectious diseases 2. Systemic versus epithelial localized immune response. The role of epithelial cells in the resolution of infection. 3. Immune response against viruses 4. HIV – epidemiology and treatment (prof. Ladislav Machala, FN Bulovka) 5. HIV – clinical perspective (prof. Ladislav Machala, FN Bulovka) 6. Covid, flu (prof. Ladislav Machala, FN Bulovka) 7. Immune response against bacteria I. – Tolerance versus immunity, symbionts, pathobionts, pathogens 8. Immune response against bacteria II. – Microbiome composition 9. Immune response against bacteria III.– Dysbiosis, Immune response to pathogens 10. Bacterial infections - clinical aspects 11. Immune response against fungi 12. Immune response against parasites Last update: Dobeš Jan, doc. Mgr., Ph.D. (26.09.2024)
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Jistě, zde je překlad textu do angličtiny: English Translation of Learning Outcomes1. Understanding and Differentiation of Fundamental Mechanisms (Understand, Analyze) The student will explain (Understand) and distinguish (Analyze) between systemic and epithelial immune responses and describe (Understand) the key role of the epithelium in protection against infection. They will be able to analyze (Analyze) the principles of Tolerance vs. Immunity in the context of bacterial infection and define (Remember) the terms symbionts, pathobionts, and pathogens. 2. Analysis of Specific Responses to Various Pathogens (Analyze, Compare) The student will conduct a comprehensive breakdown (Analyze) of the mechanisms of immune response against viral infections (including models like Covid and influenza), bacterial infections (including the microbiome and dysbiosis), fungal infections, and multicellular parasites. Subsequently, they will compare (Analyze) and distinguish the main effector cells and molecules (e.g., Th1/Th2 polarization, antibodies, cytotoxic cells, innate immune cells) utilized for the elimination of individual classes of pathogens. 3. Application of Knowledge to Clinical Cases and Epidemiology (Apply, Analyze) The student will interpret (Apply) current therapeutic strategies for specific infections. Based on presented case studies, they will be able to analyze (Analyze) and diagnose (Apply) pathological conditions related to infectious diseases and propose (Apply) principles for immunologically focused treatment. 4. Critical Analysis and Synthesis of Scientific Publications (Analyze, Evaluate, Create) The student will critically analyze (Analyze) and evaluate (Evaluate) the content of key recent scientific publications (including reviews and original articles) related to the topic of the lesson. They will be able to synthesize (Create) information from the studied publications and integrate (Apply) it into the context of the overall immune defense against the specific pathogen. 5. Active Discussion and Professional Communication (Apply, Evaluate) The student will actively participate (Apply) in interactive discussions during each lesson, where they defend (Evaluate) and support (Evaluate) their conclusions based on the studied scientific literature. They will lead (Apply) a professional discussion with the lecturer and colleagues on the topic of immune response mechanisms in English. Last update: Dobeš Jan, doc. Mgr., Ph.D. (06.01.2026)
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The basic background in immunology (please see courses: MB150P14B or MB150P14E) is essential for enrolling in this course. It is highly advantageous if students also pass additional immunology-related courses prior to taking the Immunology of infectious disease course (eg. MB150P15A, MB150P13, MB150P90E). Last update: Dobeš Jan, doc. Mgr., Ph.D. (21.07.2022)
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