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Last update: doc. RNDr. Ing. Vladimír Krylov, Ph.D. (27.05.2019)
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Last update: doc. RNDr. Ing. Vladimír Krylov, Ph.D. (27.05.2019)
The course is based on the up to date reviews, primary scientific papers and world textbooks such as Gilbert et al., Developmental biology. |
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Last update: doc. RNDr. Ing. Vladimír Krylov, Ph.D. (29.01.2021)
Requirements to the exam 100 - 90 points = 1 89 - 80 points = 2 59 - 0 points = 4 (not pass)
In the case you can´t work out the test at the faculty (foreign students, COVID issue etc), please let me know and I arrange the distant form for you. You will be invited to share your desktop and your face must be monitored by camera. If you don´t pass the writting test, the subsequent correction terms will be arranged via online or personal oral examination. |
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Last update: doc. RNDr. Ing. Vladimír Krylov, Ph.D. (12.09.2023)
1) From genotype to phenotype - changes in gene expression regarding developmental processes - Jiri Pergner Changes in the large-effect gene regulation leading to the large phenotypic changes (i.e. mutations in enhancers; mutations leading to the formation of silencers) vs. small phenotypic changes caused by the changes in gene expression of many genes. Shadow enhancers as a tool to ensure the robustness of the transcription regulation. Presentation of non-standard model organisms employed in the evo-devo studies. Gene regulatory networks (GRN) during development, their features, logic, hierarchy and spatial and temporal sequence. GRN components and mutual relationships, module examples, nods and their networking, inputs and outputs, cis regulation. GRN during embryonic development and cell line specification in sea urchin model. GRN modifications and the evolution of body plans, evolutionary stability of Kernels and plasticity of periphery parts. Evolution of new characters by modifying existing GRNs or co-opting GRNs for new features. 3) Role of the genome 3D structure and “junk DNA” in developmental processes - Jiří Pergner Up to date perspective on the genome 3D structure regarding the regulation of transcription - Topologically associated domains (TADs). TADs features, their changes in the evolution and during ontogenesis. Non-coding RNAs regulating the gene expression 4) Early embryogenesis of non-vertebrates - Marie Macurkova New views on the mosaic and regulatory development, asymetry, the effect of the stochastic gene expression, comparison of the early embryonic development regarding well established and new non-vertebrate model organisms. Signalling pathways regulating the development of selected organ systems, differences and similarities among various animal groups, transcriptomics on the organ level. 6) Advances in Epithelial Developmental Biology - Robert Černý Ectoderm-endoderm interactions in developing vertebrate head 7) Limb development in vertebrates - Vladimír Krylov 8) Regeneration - Vladimir Soukup Regeneration vs. healing. Examples of regenerating tissues in the animal kingdom, regeneration in vertebrates. Tailed amphibians as masters of regeneration. Tail and limb regeneration. Dedifferentiation, transdifferentiation and cellular processes during regeneration. Regeneration as a repetition of development?) 9) Embryonic development of the organs basis in vertebrates - Vladimír Krylov Embryonic development of the heart, digestive and respiratory tract, primary gonads and kidney. Evolutionary comparison. 10) Advances in Mesenchyme Developmental Biology - Robert Černý Neural crest-derived mesenchyme as the prime example of developmental biology of mesenchymal cells
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Last update: RNDr. Nataša Šebková, Ph.D. (12.09.2019)
Zvládnout výuku v anglickém jazyce. |