Molecular mechanisms of apoptosis - MB150P79E
Title: Molecular mechanisms of apoptosis
Czech title: Molekulární mechanismy apoptózy
Guaranteed by: Department of Cell Biology (31-151)
Faculty: Faculty of Science
Actual: from 2023 to 2023
Semester: winter
E-Credits: 3
Examination process: winter s.:
Hours per week, examination: winter s.:2/0, Ex [HT]
Capacity: unlimited
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
State of the course: taught
Language: English
Explanation: nahrazen MB150P120E
Note: enabled for web enrollment
Guarantor: RNDr. Ladislav Anděra, CSc.
Teacher(s): RNDr. Ladislav Anděra, CSc.
Is incompatible with: MB150P120E
Opinion survey results   Examination dates   WS schedule   
Annotation -
Last update: doc. RNDr. František Půta, CSc. (07.02.2018)

The lecture course is mainly focused on the presentation of various mechanisms of activation and modulation of regulated cell death (apoptosis, regulated necrosis, etc.) predominantly in mammalian (mouse and human) cells/organisms and on cell death-related processes. In addition to mammalian cells the mechanisms of regulated cell death will be addressed also in cells of other vertebrates, invertebrates, single cell organisms and plants. Lastly, role or importance of regulated cell death in a number of physiological and pathophysiological processes occurring in organisms is shown and methods of detection and quantification of cell death are presented.
Literature
Last update: doc. RNDr. František Půta, CSc. (07.02.2018)

The lectures in Powerpoint are accesible on internet (web address and access will be specified in the first lecture). On the same web address will be also accessible for downloading recent reviews and breakthrough primary paper related to the subject of respective lecture. 
Requirements to the exam
Last update: RNDr. Ladislav Anděra, CSc. (12.10.2020)

The exam is in a written form of test containing a section of quiz questions, then part encompassing short questions and answers and finally two more complex questions dealing with in detail description or assesment of an important mechanism(s) or process(es) in regulated cell death. 

This lecture is presented together/substituted by the lecture Molecular mechanisms of regulated cell death MB150P120E 

Academic year: 2020/2021:

During anti-epidemic measures the lectures will be presented online via web using Google meet (timing as regular lecture - i.e. Tuesdays at 13:00).

Contact Email: Ladislav.andera@ibt.cas.cz
Syllabus -
Last update: doc. RNDr. František Půta, CSc. (07.02.2018)

1. Definition of programmed or regulated cell death, its historical and evolution-related aspects and importance for life of an organism. Overview of principles and signalling in various forms of regulated cell death.

2. Caspase-dependent apoptosis: Initiator and effector caspases, their activation, regulation and function.

3. Mitochondria and other organelles in apoptosis; proteins from Bcl-2 family.

4. Intracellular or intrinsic induction of apoptosis, stress response, p53 tumour suppressor.

5. Extracellular or extrinsic induction of apoptosis (death receptors, immune system etc.).

6. Regulated necrosis and other mechanisms of regulated cell death.  

7. Final steps in cell destruction, removal of the corpses.

8. Summary of activation and regulation of cell death in mammalian cells.

9. Regulated cell death in other vertebrates and in invertebrates.

10. Regulated cell death in single cell organisms and in plants.

11. Physiology and pathophysiology of regulated cell death; methods of cell death detection and quantification.