SubjectsSubjects(version: 875)
Course, academic year 2020/2021
  
Antiviral Drug Discovery - MB140P97
Title: Antiviral Drug Discovery
Czech title: Antivirotika a jejich výzkum
Guaranteed by: Department of Genetics and Microbiology (31-140)
Faculty: Faculty of Science
Actual: from 2020
Semester: winter
E-Credits: 3
Examination process: winter s.:oral
Hours per week, examination: winter s.:2/0 Ex [hours/week]
Capacity: unlimited
Min. number of students: unlimited
State of the course: taught
Language: English
Level: specialized
Guarantor: Mgr. Klára Grantz Šašková, Ph.D.
Teacher(s): Mgr. Klára Grantz Šašková, Ph.D.
Opinion survey results   Examination dates   Schedule   
Annotation -
Last update: RNDr. Irena Lichá, CSc. (12.02.2020)
Antiviral Drug Discovery is an advanced course that brings a comprehensive overview of antiviral drugs approved
over the past decades, focusing on research and development of effective antiviral treatment against current and
emerging viruses such as HIV, HBV, HCV, HSV, HCMV, HPV, RSV, VZV, and influenza virus. The course is
oriented primarily to the needs of biology and biomedical students at the upper undergraduate and advanced
academic degrees (Master and Ph.D. candidates) who wish to expand their knowledge in antiviral drug discovery
and medicinal chemistry. The students will have the opportunity to learn what has been done to develop
successful antiviral therapy, the drawbacks along the way and the tactical aspects of problem solving in antiviral
drug design.
Literature -
Last update: RNDr. Irena Lichá, CSc. (12.02.2020)

Research and review papers available online

Websites with up-to-date viral disease and treatment information (CDC, WHO, etc.)

Antiviral Strategies (Krausslich, Bartenschlager), Springer-Verlag Berlin and Heidelberg GmbH & Co. KG, 2008Successful Strategies for the Discovery of Antiviral Drugs (Manoj C. Desai), Royal Society of Chemistry, 2013

Syllabus
Last update: RNDr. Irena Lichá, CSc. (12.02.2020)

1. Introduction Into Antiviral Strategies

  • Principes of Viral Replication and Its Inhibition
  • Principles of Development of Antivirals
  • Current Status of Antiviral Therapy
  • General Antiviral Strategies
  • Antiviral Resistance

2. Development of Antiviral Compounds: The Case of Human Immunodeficiency Virus

3. Development of Antiviral Compounds: The Case of Hepatitis C Virus

4. Development of Antiviral Compounds: The Case of Hepatitis B Virus

5. Development of Antiviral Compounds: The Case of Influenza Virus and Coronaviruses

6. Development of Antiviral Compounds: The Case of Ebola, Dengue and Zika Viruses

7. Antiviral Agents Acting as DNA or RNA Chain Terminators

8. Viral Protease Inhibitors

9. Inhibitors of Viral Entry

10. Inhibitors of Viral Assembly

11. Nucleic Acid-Based Therapeutics

12. Antiviral Gene Therapy

 
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