SubjectsSubjects(version: 850)
Course, academic year 2019/2020
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Medical Virology and Viral Pathogenesis - MB140P91
Title in English: Medical Virology and Viral Pathogenesis
Czech title: Medicinální virologie a virová patogeneze
Guaranteed by: Department of Genetics and Microbiology (31-140)
Faculty: Faculty of Science
Actual: from 2015 to 2019
Semester: winter
E-Credits: 3
Examination process: winter s.:
Hours per week, examination: winter s.:2/0 Ex [hours/week]
Capacity: unlimited
Min. number of students: unlimited
State of the course: taught
Language: English
Level: specialized
Guarantor: doc. RNDr. Ivan Hirsch, CSc.
Teacher(s): doc. RNDr. Ivan Hirsch, CSc.
Mgr. Kateřina Trejbalová, Ph.D.
Annotation -
Last update: RNDr. Jana Rubešová, Ph.D. (21.01.2014)
Medical Virology and Viral Pathogenesis is an advanced level virology course that focuses on various aspects of
viral infection, virus spread, host response to viral infections, latency and persistency. This course is oriented
primarily to the needs of biology and biomedical students at the upper undergraduate and advanced academic
degrees (Master and Ph.D. candidates) who wish to expand their knowledge in human virology beyond the basic
microbiology level (which is required). Students will have the opportunity to learn the most recent state of
knowledge on various aspects of human virology. Proposed course places particular emphasis on viruses which
cause disease in humans.
Literature -
Last update: doc. RNDr. Ivan Hirsch, CSc. (26.02.2016)

Research and review papers available online
Websites with up-to-date viral disease information (CDC, WHO, etc.)
Fields Virology (Knipe, Fields Virology) 2 volume set, by David M. Knipe, Peter M. Howley. Publishers LWW
Principles of virology. Vol. 1 and 2, Molecular biology. S.J. Flint et al. 3rd ed. Imprint Washington, DC:
ASM Press, 2009.

Requirements to the exam
Last update: doc. RNDr. Ivan Hirsch, CSc. (26.02.2016)

The students' performance will be graded as satisfactory/unsatisfactory on the basis of constructive participation in the seminars (paper presentation) and in-class discussions. Two-page home-prepared essay on selected subject will be discussed during the final evaluation. This is a thematic oriented class with contributions expected from each student. Lectures will follow up with assigned papers to be discussed by the students in the class. The students are responsible for reviewing the papers and presenting the contents of the paper for general discussion.

Last update: doc. RNDr. Ivan Hirsch, CSc. (26.02.2016)

Mechanisms of viral restriction and adaptation during acute, persistent, chronic and latent infection

1.    Types of infection (acute, persistent, chronic, slow), restriction / innate and natural immunity; interferon(s) - cytokines

2.    Virus restriction during and after virus entry into the cell - virus receptors

3.    Virus restriction during and after virus entry into the cell - restriction factors

4.    Acute infections: influenza virus, restriction and adaptation

5.    Chronic infection: hepatitis C and B, restriction and adaptation

6.    Persistent and latent infection: active and passive role of the virus (herpesviruses and retroviruses)

7.    Latent infection by Epstein-Barr virus and Kaposi sarcoma virus

8.    HIV persistence and latency

9.    Persistent and latent phase of infection by other retroviruses

10.  Slow an latent infection by HIV, MMTV and LCMV

11.  Million years taking persistence of retroviruses: endogenic retroviruses

12.  Control of virus infection in the host population


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