SubjectsSubjects(version: 901)
Course, academic year 2022/2023
Molecular and Immunologic mechanism of viral pathogenesis - MB140P91
Title: Molecular and Immunologic mechanism of viral pathogenesis
Czech title: Molekulární a imunologické mechanismy virové pathogeneze
Guaranteed by: Department of Genetics and Microbiology (31-140)
Faculty: Faculty of Science
Actual: from 2022
Semester: winter
E-Credits: 3
Examination process: winter s.:
Hours per week, examination: winter s.:2/0 Ex [hours/week]
Capacity: unlimited
Min. number of students: unlimited
Virtual mobility / capacity: no
State of the course: taught
Language: English
Level: specialized
Note: enabled for web enrollment
Guarantor: prof. RNDr. Ivan Hirsch, CSc.
Mgr. Kateřina Trejbalová, Ph.D.
Teacher(s): prof. RNDr. Ivan Hirsch, CSc.
Mgr. Kateřina Trejbalová, Ph.D.
Opinion survey results   Examination dates   Schedule   
Annotation -
Last update: prof. RNDr. Ivan Hirsch, CSc. (16.10.2020)
Medical Virology and Viral Pathogenesis is an advanced level virology course that focuses on various aspects of viral infection, virus spread, host response to viral infections, latency and persistency. This course is oriented primarily to the needs of biology and biomedical students at the upper undergraduate and advanced academic degrees (Master and Ph.D. candidates) who wish to expand their knowledge in human virology beyond the basic microbiology level (which is required). Students will have the opportunity to learn the most recent state of knowledge on various aspects of human virology. Proposed course places particular emphasis on viruses which cause disease in humans. During the period of anti-epidemic measures, the lectures will be given online via the Google-Meet communication platform at the time indicated in the schedule.
Literature -
Last update: RNDr. Jana Rubešová, Ph.D. (08.06.2022)

Research and review papers available online
Websites with up-to-date viral disease information (CDC, WHO, etc.)
Fields Virology (Knipe, Fields Virology) 2 volume set, by David M. Knipe, Peter M. Howley. Publishers LWW 2020
Principles of virology. Vol. 1 and 2, Molecular biology. S.J. Flint et al. 4th ed. Imprint Washington, DC: ASM Press, 2015. Accessible at

Requirements to the exam
Last update: prof. RNDr. Ivan Hirsch, CSc. (16.10.2020)

The students' performance will be graded as satisfactory/unsatisfactory on the basis of constructive participation in the seminars (paper presentation) and in-class discussions. Two-page home-prepared essay on selected subject will be discussed during the final oral evaluation. This is a thematic oriented class with contributions expected from each student. Lectures will follow up with assigned papers to be discussed by the students in the class. The students are responsible for reviewing the papers and presenting the contents of the paper for general round-table discussion.

Syllabus -
Last update: prof. RNDr. Ivan Hirsch, CSc. (15.10.2020)

Mechanisms of viral restriction and adaptation during acute, persistent, chronic and latent infection

1. Types of infection (acute, persistent, chronic, slow), restriction / innate and natural immunity; interferon(s) - cytokines

2. Acute infections: influenza virus, restriction and adaptation

3. HIV persistence and latency

4. Persistent and latent phase of infection by other retroviruses

5. Million years taking persistence of retroviruses: endogenous retroviruses

6. Persistent and latent infection: active and passive role of the virus (herpesviruses and retroviruses)

7. Chronic type of infection, LCMV and HBV

8. Virus restriction during and after virus entry into the cell - restriction factors

9. Zoonoses, viral receptors and adaptation

10. Vaccines (KT) + students presentations  

11.  Control of virus infection in the host population

12. Students‘ round table discussion (viral tropism)

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