SubjectsSubjects(version: 978)
Course, academic year 2025/2026
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Pathogenesis, epidemiology and diagnostics of selected human and animal diseases. - MB140P85
Title: Patogeneze, epidemiologie a diagnostika vybraných virových onemocnění lidí a zvířat
Czech title: Patogeneze, epidemiologie a diagnostika vybraných virových onemocnění lidí a zvířat
Guaranteed by: Department of Genetics and Microbiology (31-140)
Faculty: Faculty of Science
Actual: from 2024
Semester: summer
E-Credits: 3
Examination process: summer s.:combined
Hours per week, examination: summer s.:2/0, Ex [HT]
Capacity: unlimited
Min. number of students: 5
4EU+: no
Virtual mobility / capacity: no
State of the course: taught
Language: Czech
Level: specialized
Note: enabled for web enrollment
Guarantor: prof. RNDr. Ruth Tachezy, Ph.D.
Teacher(s): prof. MVDr. Vladimír Celer, Ph.D.
MVDr. Dobromila Molinková, Ph.D.
prof. RNDr. Ruth Tachezy, Ph.D.
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download Tachezy - Patogeneze2.docx Instructions for summer term 2020/21 RNDr. Michaela Schierová, Ph.D.
Annotation -
In LS 2025/22026: Lectures will be held regularly on Thursdays at 10:45 a.m., starting on February 19. Only in the event of a business trip or illness of the lecturer will they be held online on the GoogleMeet platform.
Examination conditions – written exam. After achieving the minimum number of points, an oral exam will be held.
Presentations will be available on the course coordinator's Google Drive.
More information will be provided during the first lecture.

The lecture will focus primarily on viruses that cause common diseases in humans and animals and are routinely diagnosed in practice. The main emphasis will be on diagnostic principles and epidemiological aspects.
The introduction will define some basic concepts of pathogenesis, epidemiology, and molecular epidemiology, the principles of evaluating diagnostic methods and commercial tests, the methods and principles of work in a virology laboratory, the principles of good laboratory practice, and primary prevention - vaccination.
Further lectures will focus on groups of viruses that cause diseases with similar clinical manifestations, e.g., respiratory viruses, viruses that cause hepatitis, etc. For each group, the mode of transmission, incubation period, types of infection, clinical manifestations, diagnosis, prevention, and prophylaxis will be discussed.
Lectures focused on animal viruses will be divided into viruses causing zoonoses or having zoonotic potential, viruses of exceptional economic importance, and finally, viruses with remarkable or as yet unexplained pathogenesis of disease.
Completion of a basic virology course is expected.
Last update: Tachezy Ruth, prof. RNDr., Ph.D. (13.01.2026)
Literature

Literature: 

The molecular epidemiology of human viruses: ed. Thomas Leitner, 2002
Veterinary Virology: Frederick A. Murphy, E. Paul J. Gibbs, Marian C. Horzinek, Michael J. Studdert, Third Edition,
Epidemiologic methods in studying chronic diseases: Jedrychowski W. a Maugeri U., 2000
Cancer epidemiology: principles and methods: IARC 1999
Encyclopedia of Virology: Granoff and Webster ed., 2nd edition, 1999
Medical Virology: White and Fenner, 4th edition, 1994
Medical Microbiology: Murray, Rosenthal, Kobayashi, Pfaller, 4th edition, 2002
Fields Virology: Fields, Knipe and Howley, 3rd edition, 1996
Viruses and Human Disease: Strauss and Strauss, 2nd edition, 2007

Last update: Tachezy Ruth, prof. RNDr., Ph.D. (25.10.2019)
Requirements to the exam

Students must past written and oral part of the exam.  

Written exam:

Maximum 5 points per question. Altogether 210 points.

To be able to continue to oral exam the minimum of  > 105 points (50%) has to be reached, but the best mark will be than 3 without the possibility to improve it during the oral examination.

126 – 147 bodů           3

148 – 168 bodů           2

169 – 210 bodu           1

 

105            50%

126            60%

147            70%

168            80%

189            90%

Last update: Tachezy Ruth, prof. RNDr., Ph.D. (25.10.2019)
Syllabus -

Pathogenesis of viral diseases. Basic concepts of epidemiology and molecular epidemiology. Types of studies, concepts of prevalence, incidence, mortality, morbidity, principles of using molecular epidemiology in virology, proving the etiological link between viral infection and disease, disease eradication, epidemics, and pandemics.
Laboratory methods. Overview of diagnostic methods used in routine practice and their principles, collection of clinical samples, transport, pre-analytical phase of clinical material processing, good laboratory practice (e.g., external quality assessment, laboratory accreditation, recommendations), sensitivity, specificity, PPV, NPV, RLU curve, analytical sensitivity, clinical sensitivity of diagnostic tests, in vitro diagnostics, and reliability of commercial kits.


HBV, HAV, HCV, and other viruses which cause hepatitis
Herpes viruses - HSV1,2, CMV, EBV, HHV6, HHV8, VZV
Influenza and other respiratory viruses
HIV, HPV
Viral gastroenteritis - rotaviruses, noroviruses, astroviruses
Rubella, mumps, measles
Viral infections of the CNS - tick-borne encephalitis, JCV
Newly emerging and recurrent infections - Zika, Dengue, Yellow fever virus
Zoonoses – rabies virus, mammalian and avian influenza viruses, paramyxoviruses
Economically significant viral infections in animals – pestiviruses, foot-and-mouth disease virus, Newcastle disease virus
Infections in dogs and cats (herpesviruses, caliciviruses)

Last update: Tachezy Ruth, prof. RNDr., Ph.D. (13.01.2026)
 
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