|
|
|
||
Last update: RNDr. Jaroslav Nunvář, Ph.D. (16.10.2018)
taxonomic approaches are presented and important taxa are described. In the evolutionary part, emphasis is put on evolution of peculiar prokaryotic lifestyles (nutrient symbionts, pathogens). The course further focuses on sources of evolutionary variability and evolution of defence against selective pressures of biotic nature (selfish genetic elements, antibiotics, host immune system). Basic courses in Microbiology and Evolutionary biology are recommended as a prerequisite. |
|
||
Last update: RNDr. Jaroslav Nunvář, Ph.D. (23.10.2019)
Books: Madigan M.T. et al.: Brock Biology of Microorganisms (15th Edition). Pearson, 2018 Brown J.W.: Principles of Micribial Diversity. ASM Press, 2015 Rosenberg E. et al. (Eds.): The Prokaryotes (4th Edition). Springer, 2014 Whitman W.B (Ed.).: Bergey’s Manual of Systematics of Archaea and Bacteria. Wiley, 2015
selected recommended reviews |
|
||
Last update: RNDr. Jaroslav Nunvář, Ph.D. (23.10.2019)
students will be evaluated on the basis of an oral exam |
|
||
Last update: RNDr. Jaroslav Nunvář, Ph.D. (23.10.2019)
Molecular taxonomy, prokaryotic species prokaryotic x eukaryotic species, phylogenetic markers and their sensitivity, singlegene x multigene x whole-genome approaches Early evolution, major branches two prokaryotic realms and their discovery, LUCA and its predicted feaures, prokaryotic influence on early ecosystems, eukaryogenesis from archaea Systematics I Terrabacteria: major taxa, their evolution and distinctive traits Systematics II Hydrobacteria: major taxa, their evolution and distinctive traits Sources and mechanisms of evolutionary variability point mutations, frameshift mutations (contingency loci), IS elements, hypermutability (mutation rate, evolution of evolvability), horizontal gene transfer and mobile genetic elements Evolution of patogenicity evolutionary trajectory from a fre--living to pathogenic bacterium, immune evasion, obligate host association, genetically monomorpic pathogens Evolution of defence protection from MGE (CRISPR,RM systems), protection of MGE from host defenses, evolution of ATB resistance Evoluce kooperace nutritional symbioses (sap-feeding insects, hydrothermal vents, rhizobia), bioluminescent symbioses |