Pharmaceutical Technology II - GF346
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The Pharmaceutical Technology II (PhT2) course focuses on the production of technologically demanding, primarily industrially produced, dosage forms (solid dosage forms, sterile dosage forms, aerodispersions, particulate carriers for the delivery of active substances, vaccines, radiopharmaceuticals, and others). It includes topics focused on understanding the structure of drug delivery systems with modified release ((prolonged, delayed, pulsatile release, and targeted API distribution) and API release mechanisms.<br>
Practical training allows students to acquire additional skills necessary for magistraliter preparation of medicinal products in pharmacies, correct application of pharmaceutical calculations required for preparation, including API dose control, adjustment of the preparation and its labeling, possibilities of product stabilization and determination of shelf life. It also includes seminar topics deepening knowledge of specific procedures used in the formulation, preparation or evaluation of medicinal products.
Last update: Šklubalová Zdeňka, doc. PharmDr., Ph.D. (17.03.2025)
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The subject PhT2 is completed with a credit. The exam (written) in the subject Pharmaceutical Technology II is common with the subject PhT1. The course is concluded with a final oral state exam. The following conditions conditions should be fulfilled for credit: Completing practical exercises to the extent prescribed by the study plan. 100% participation in classes is required proper keeping of protocols from the practical training 75% of correct answers in each of the final tests Last update: Šklubalová Zdeňka, doc. PharmDr., Ph.D. (17.03.2025)
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Obligatory:
Last update: prepocet_literatura.php (19.09.2024)
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lecture seminar practical training Last update: Šklubalová Zdeňka, doc. PharmDr., Ph.D. (04.12.2021)
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The confirmation of credits
Last update: Šklubalová Zdeňka, doc. PharmDr., Ph.D. (17.03.2025)
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The subject Pharmaceutical Technology II (PhT2) builds on the knowledge and skills acquired in the subject Pharmaceutical Technology I and its preceding courses. Based on the acquired knowledge and skills, students will: • select and assess the suitability of excipients in the formulation of solid dosage forms in relation to their granulometric and bulk characteristics and compressibility, explain the principles of methods used for the production of solid dosage forms; evaluate the risks of the production process with regard to ensuring dose uniformity; • explain the principles of methods used for the production of sterile dosage forms, assess their importance for achieving the quality of the final product; propose a suitable procedure for assessing the quality of sterile dosage forms with regard to its safety; • perform bacterial retentive filtration; • explain the principles of aerodispersion formation, propose appropriate quality tests in regard to ensuring dose uniformity; • explain the principles of the formation of dosage forms with prolonged, delayed, pulsatile release and targeted API distribution; • explain the importance/role of excipients used in dosage forms with immediate and modified API release using examples; characterize particulate carriers for the administration of medicinal substances; • propose the design of dosage forms with modified API release with regard to the application and therapeutic goal. Last update: Šklubalová Zdeňka, doc. PharmDr., Ph.D. (17.03.2025)
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Web FaF: https://intranet.faf.cuni.cz/Study-materials/KFT/?path=pharmaceutical+technology Last update: Šklubalová Zdeňka, doc. PharmDr., Ph.D. (04.12.2021)
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The subject Pharmaceutical Technology II (PhT2) builds on the knowledge and skills acquired in the subject Pharmaceutical Technology I and its preceding courses. After completing the subject, students will be able to use the following terms (including their commonly used abbreviations) in the correct context towards the preparation, production and quality requirements of medicinal products: registered LP, GMP, documentation and validation in pharmaceutical production, stability and stabilization of medicinal product, production of solid dosage forms, production of sterile LP, types of API release from dosage forms, mechanisms of API release from dosage forms, principles of production of dosage forms with prolonged, delayed, pulsatile and targeted API release. Learning outcomes: Based on the acquired knowledge and skills, students will: • select and assess the suitability of excipients in the formulation of solid dosage forms in relation to their granulometric and bulk characteristics and compressibility, explain the principles of methods used for the production of solid dosage forms; evaluate the risks of the production process with regard to ensuring dose uniformity; • explain the principles of methods used for the production of sterile dosage forms, assess their importance for achieving the quality of the final product; propose a suitable procedure for assessing the quality of sterile dosage forms with regard to its safety; • perform bacterial retentive filtration; • explain the principles of aerodispersion formation, propose appropriate quality tests in regard to ensuring dose uniformity; • explain the principles of the formation of dosage forms with prolonged, delayed, pulsatile release and targeted API distribution; • explain the importance/role of excipients used in dosage forms with immediate and modified API release using examples; characterize particulate carriers for the administration of medicinal substances; • propose the design of dosage forms with modified API release with regard to the application and therapeutic goal. Last update: Šklubalová Zdeňka, doc. PharmDr., Ph.D. (17.03.2025)
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