SubjectsSubjects(version: 941)
Course, academic year 2022/2023
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Test methods of pharmaceutical technology - GDFT04
Title: Zkušební metody farmaceutické technologie
Guaranteed by: Department of Pharmaceutical Technology (16-16210)
Faculty: Faculty of Pharmacy in Hradec Králové
Actual: from 2018
Semester: both
Points: 0
E-Credits: 0
Examination process:
Hours per week, examination: 0/0, Ex [HT]
Capacity: winter:unknown / unknown (unknown)
summer:unknown / unknown (unknown)
Min. number of students: unlimited
Virtual mobility / capacity: no
Key competences:  
State of the course: taught
Language: Czech
Teaching methods: full-time
Teaching methods: full-time
Note: course is intended for doctoral students only
enabled for web enrollment
you can enroll for the course in winter and in summer semester
Guarantor: doc. PharmDr. Jitka Mužíková, Ph.D.
Annotation -
Last update: doc. PharmDr. Zdeňka Šklubalová, Ph.D. (16.03.2018)
The evaluation of quality of raw materials, semi-finished and finished pharmaceutical dosage forms has a dominant role in the production of pharmaceutical products. Key factors include the uniformity of dosage units, mechanical resistance, biopharmaceutical aspects (dissolution profile) and microbiological quality. Modern test methods of pharmaceutical technology include the characterization of solid phase, crystallinity and/or amorphous state (X-ray powder diffraction, thermal analysis), the evaluation of surface properties (wettability, porosity and pore distribution, water sorption and desorption), and particle size estimation (laser diffraction, optical microscopy, aerodynamic parameters). The subject is supplemented by general physico-chemical methods such as the pH, relative density, refractive index, optical rotation, viscosity, boiling point and solidification point estimation,as well as the osmolality, drying loss, melting point and dropping point. The specific pharmaceutical methods include the penetrometry, the density of solids, sieve analysis, powder flow, powder fineness, specific surface area. However, the tests for final preparations e.g. the strength and friability of tablets, the disintegration time of tablets or suppositories, the dissolution of the drug from different dosage forms and specific methods for evaluation of sterile dosage forms (sterility, pyrogens, particle contamination, etc.) are important.
Literature -
Last update: doc. PharmDr. Jitka Mužíková, Ph.D. (27.02.2018)


  • Council of Europe. European pharmacopoeia. 9th ed. Strasbourg: , 2016, s. ISBN 978-92-871-8127-5.
  • Celik, Metin (ed.). Pharmaceutical powder compaction technology. New York: Informa Healthcare, 2011, 343 s. ISBN 978-142008917-2.
  • Akers, Michael J.. Sterile drug products : formulation, packaging, manufacturing, and quality. New York: Informa Healthcare, 2010, s. ISBN 978-084933993-6.
  • Storey, Richard A. Ymen, Ingvar (eds.). Solid state characterization of pharmaceuticals. Chichester, UK: John Wiley & Sons, 2011, 506 s. ISBN 978-1-405-13494-1.


  • Allen, Loyd V. (ed.). Science and practice of pharmacy. London ; Philadelphia: Pharmaceutical Press, 2013, 2 s. ISBN 978-0-85711-062-6.
  • Augsburger, L. L., Hoag S. V.. Pharmaceutical Dosage Forms: Tablets. Volume 3: Manufacture and Process Control. 3rd ed. . New York: Informa Healthcare, 2008, 311 s. s. ISBN 978-0-8493-9016-6.

Requirements to the exam -
Last update: doc. PharmDr. Zdeňka Šklubalová, Ph.D. (16.03.2018)

Student will demonstrate theoretical knowledge and its practical application in a range corresponding to the topic of her/his disertation thesis as instructed by the guarant (or supervisor).



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