SubjectsSubjects(version: 944)
Course, academic year 2023/2024
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Selected Methods of Pharmaceutical Technology - GAPS352
Title: Selected Methods of Pharmaceutical Technology
Guaranteed by: Department of Pharmaceutical Technology (16-16210)
Faculty: Faculty of Pharmacy in Hradec Králové
Actual: from 2022
Semester: summer
Points: 0
E-Credits: 4
Examination process: summer s.:written
Hours per week, examination: summer s.:0/42, C+Ex [HS]
Capacity: unknown / unknown (5)
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
Key competences:  
State of the course: taught
Language: English
Teaching methods: full-time
Teaching methods: full-time
Is provided by: GF352
Guarantor: doc. PharmDr. Jitka Mužíková, Ph.D.
Annotation -
Last update: Ing. Lucie Navrátilová (26.06.2020)
The subject enables students interested in the employment in pharmaceutical industry to get more profound theoretical and practical knowledge in the field of some of the specialized manufacturing and control procedures of pharmaceutical technology. The methods included in the subject are related to the evaluation of incoming raw materials, preparation of intermediate products, or manufacture of final medicinal preparations and their evaluation. The orientation of the subject links up with other subjects enabling specialization of students for pharmaceutical technology.
Course completion requirements -
Last update: Ing. Lucie Navrátilová (26.06.2020)

Conditions for obtaining of the credit - 100% participation in teaching; reports

written exam

Literature -
Last update: Ing. Lucie Navrátilová (26.06.2020)


  • European Directorate for the Quality of Medicines. European Pharmacopoeia 9th Edition . : , 2016, s. ISBN 978-92-871-8127-5.
  • Celik, Metin (ed.). Pharmaceutical powder compaction technology . New York: Informa Healthcare, 2011, 143-204; 205-234 s. ISBN 978-142008917-2.
  • Augsburger, L.L., Hoag, S.W.. Pharmaceutical dosage forms: Tablets . New York: Informa Healtcare USA, Inc, 2008, 251-267 s. ISBN 978-0-8493-9014-2.
  • Rowe, Raymond C. Sheskey, Paul J. Cook, Walter G. (eds.). Handbook of pharmaceutical excipients / edited by Raymond C. Rowe, Paul J. Sheskey, Walter G. Cook . London: Pharmaceutical Press, 2012, 1033 s. ISBN 978-0-85711-027-5.
  • Nyström, Christer (ed.). Pharmaceutical powder compaction technology . New York: Marcel Dekker, 1996, 77-97 s. ISBN 0-8247-9376-5.
  • PARIKH, D. M. Handbook of Pharmaceutical Granulation Technology . New York: Informa Healthcare USA. Inc, 2013, 98-125;204-260 s. ISBN 978-1-4398-0789-7.
  • Mezger, T.G. The Rheology Handbook 4th Edition . Hanover: Vincentz Network , 2014, s. ISBN 3-86630-842-6.

Syllabus -
Last update: Ing. Lucie Navrátilová (26.06.2020)
  • Differential scan calorimetry (DSC)
    • characterization of  biodegradable polymers by DSC (determination of glass transition temperature Tg)
    • polymers plasticization
    • influence of the plasticizer type and concentration on Tg
    • drug incorporation into the polymer (fusion method, plasticization method, solvent method)
    • thermal analyses of solid polymeric dispersions
  • Pycnometric density of solids, porosimetry
    • determination of tablet´s excipients density
    • determination of tableting materials density
    • determination of density and porosity of tablets in dependence on compression pressure
  • Determination of surface tension of liquids
    • determination of surface tension of water
    • determination of surface tension of surfactant solutions (cationic, anionic and nonionic)
  • Rheological evaluation of pharmaceutical preparations
    • analysis of rheogram by appropriate models
    • characterization of  semi-solid preparations by Herschel-Bulkely model (coefficient of consistency and flow behaviour)
    • thixotropy characterization of the pharmaceutical preparations
    • influence of the pharmaceutical preparations composition and technology of compounding on rheological characteristics
  • Fluid bed granulation
    • influence of process parameters on the quality of  granulates
    • preparing of a granulate and its evaluation
  • Spray drying
    • influence of process parameters on the quality of a dried product
    • evaluation of the spray dried product
  • Evaluation of the compressibility of tabletting materials and the effect of lubricants
    • evaluation of the energetic profile of dry binders and directly compressible tabletting materials
    • evaluation of the compactibility of dry binders and directly compressible tabletting materials by tensile strength of tablets
    • evaluation of the lubricant effect in tabletting materials
  • Dissolution tests
    • determination of active ingredients dissolution profile released from prolonged release tablets
    • comparison of basket, paddle and flow- through cell dissolution methods
    • influence of dissolution test´s settings on dissolution profiles
Teaching methods -
Last update: Ing. Lucie Navrátilová (26.06.2020)

seminars and practical excercises

Requirements to the exam -
Last update: Ing. Lucie Navrátilová (26.06.2020)


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