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Course, academic year 2023/2024
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Pharmaceutical Chemistry I - GAPS341
Title: Pharmaceutical Chemistry I
Guaranteed by: Department of Pharmaceutical Chemistry and Pharmaceutical Analysis (16-16190)
Faculty: Faculty of Pharmacy in Hradec Králové
Actual: from 2021
Semester: winter
Points: 0
E-Credits: 5
Examination process: winter s.:
Hours per week, examination: winter s.:42/70, C [HS]
Capacity: unknown / unknown (unknown)
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
Key competences:  
State of the course: taught
Language: English
Teaching methods: full-time
Teaching methods: full-time
Is provided by: GAF341
Note: deregister from the credit exam date if a requisite was not fulfilled
Guarantor: prof. PharmDr. Martin Doležal, Ph.D.
Is co-requisite for: GAPS342
Annotation -
Last update: prof. PharmDr. Martin Doležal, Ph.D. (08.11.2021)
Pharmaceutical Chemistry is a specific pharmaceutical subject representing the link between chemical and biological disciplines. Its task is to provide students with a complex understanding of drug and auxiliary substance chemistry. The drugs are studied from the point of view of their rational selection and preparation, quality criteria, suitable ways of storage, structure-activity and structure-metabolism relationships, and practical usage. The brief information concerning mechanisms of drug action covered in this subject forms the basis for a more profound study of this topic in pharmacology. This subject belongs to the state final examination group of subjects.
Course completion requirements - Czech
Last update: prof. PharmDr. Martin Doležal, Ph.D. (08.11.2021)

Výuka tohoto povinného předmětu - studijního plánu 3. úseku probíhá formou přednášek, seminářů a praktických cvičení. Pro získání zápočtu je nutné absolvovat všechna praktická cvičení, předepsané semináře a úspěšně splnit zadané úkoly. Předmět je ukončen ústní zkouškou.

Last update: prof. PharmDr. Martin Doležal, Ph.D. (08.11.2021)


  • . . In Williams, David A., Lemke, Thomas L. (eds.). Principles of medicinal chemistry . Baltimore: Lippincott Williams & Wilkins, 2002, s. -. ISBN 0-683-30737-1..

Syllabus -
Last update: prof. PharmDr. Martin Doležal, Ph.D. (08.11.2021)

Definition and characterization of the subject

Historical development of pharmaceutical chemistry

Sources of new drugs

Drug nomenclature

Structural factors affecting biological activity

Drug structure modifications

Physicochemical properties in relation to biological activity

Drugs affecting the central nervous system:

  • General anesthetics
  • Sedative-hypnotics
  • Anticonvulsants
  • Neuroleptics
  • Anxiolytics
  • Antidepressants
  • Psychostimulants
  • Hallucinogens
  • Antiparkinsonian agents
  • Opiate analgesics
  • Nonopiate analgesics
  • Nonsteroidal anti-inflammatory agents
  • Antiemetics
  • Antitussives
  • Expectorants

Drugs affecting the peripheral nervous system

  • Local anesthetics
  • Skeletal muscle relaxants
Learning resources -
Last update: prof. PharmDr. Martin Doležal, Ph.D. (08.11.2021)

MOODLE pro výuku 1 Univerzita Karlova

Pharmaceutical Chemistry - Practical Classes

Teaching methods -
Last update: prof. PharmDr. Martin Doležal, Ph.D. (08.11.2021)

lectures, seminars, practical classes, e-learning, consultations, autodidactic tests, credit tests, oral examination

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